Výsledky vyhledávání - "Mark R Walter"

Akademický článek

Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody.

Autor: Michael S Piepenbrink, Jun-Gyu Park, Ashlesha Deshpande, Andreas Loos, Chengjin Ye, Madhubanti Basu, Sanghita Sarkar, Ahmed Magdy Khalil, David Chauvin, Jennifer Woo, Philip Lovalenti, Nathaniel B Erdmann, Paul A Goepfert, Vu L Truong, Richard A Bowen, Mark R Walter, Luis Martinez-Sobrido, James J Kobie

Publikováno v: PLoS Pathogens, Vol 18, Iss 7, p e1010691 (2022)

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) marks the third novel β-coronavirus to cause significant human mortality in the last two decades. Although vaccines are available, too few have been administered worldwide to keep the viru

Externí odkaz: https://doaj.org/article/cdcf68c2004649efa158bcfc0b8de359

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Akademický článek

Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN.1 and other variants

Publikováno v: npj Viruses, Vol 2, Iss 1, Pp 1-10 (2024)

Abstract SARS-CoV-2 continues to be a public health burden, driven in-part by its continued antigenic diversification and resulting emergence of new variants. By increasing herd immunity, current vaccines have improved infection outcomes for many. Ho

Externí odkaz: https://doaj.org/article/fc93c8dbfeef47ec8f5ad7779811e16c

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Akademický článek

Host immune responses to a viral immune modulating protein: immunogenicity of viral interleukin-10 in rhesus cytomegalovirus-infected rhesus macaques.

Autor: Meghan K Eberhardt, W L William Chang, Naomi J Logsdon, Yujuan Yue, Mark R Walter, Peter A Barry

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37931 (2012)

BackgroundConsiderable evidence has accumulated that multiple viruses, bacteria, and protozoa manipulate interleukin-10 (IL-10)-mediated signaling through the IL-10 receptor (IL-10R) in ways that could enable establishment of a persistent microbial i

Externí odkaz: https://doaj.org/article/410cfbf39d024c269da64e8987589c51

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Akademický článek

Design and analysis of rhesus cytomegalovirus IL-10 mutants as a model for novel vaccines against human cytomegalovirus.

Autor: Naomi J Logsdon, Meghan K Eberhardt, Christopher E Allen, Peter A Barry, Mark R Walter

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e28127 (2011)

Human cytomegalovirus (HCMV) expresses a viral ortholog (CMVIL-10) of human cellular interleukin-10 (cIL-10). Despite only ∼26% amino acid sequence identity, CMVIL-10 exhibits comparable immunosuppressive activity with cIL-10, attenuates HCMV antiv

Externí odkaz: https://doaj.org/article/8c17b5e8586c4d19afdd7d42380cce20

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Akademický článek

Immunization with Recombinant Accessory Protein-Deficient SARS-CoV-2 Protects against Lethal Challenge and Viral Transmission

Autor: Chengjin Ye, Jun-Gyu Park, Kevin Chiem, Piyush Dravid, Anna Allué-Guardia, Andreu Garcia-Vilanova, Paula Pino Tamayo, Vinay Shivanna, Amit Kapoor, Mark R. Walter, James J. Kobie, Richard K. Plemper, Jordi B. Torrelles, Luis Martinez-Sobrido

Publikováno v: Microbiology Spectrum, Vol 11, Iss 3 (2023)

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a worldwide coronavirus disease 2019 (COVID-19) pandemic. Despite the high efficacy of the authorized vaccines, there may be uncertain and unknown side effects or disadv

Externí odkaz: https://doaj.org/article/fabdbacf676945fcb48c369205349169

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Data from BiP/GRP78 Is an Intracellular Target for MDA-7/IL-24 Induction of Cancer-Specific Apoptosis

Autor: Paul B. Fisher, Devanand Sarkar, Kristoffer Valerie, Aaron Randolph, Luni Emdad, Irina V. Lebedeva, Zao-zhong Su, Mark R. Walter, Pankaj Gupta

Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that induces cancer-selective growth suppression and apoptosis in a wide spectrum of human cancers in cell culture and animal models.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce29768368f8cc64c31211e3b016817
https://doi.org/10.1158/0008-5472.c.6494534.v1

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Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing Virus

Autor: Kevin Chiem, Jun-Gyu Park, Desarey Morales Vasquez, Richard K. Plemper, Jordi B. Torrelles, James J. Kobie, Mark R. Walter, Chengjin Ye, Luis Martinez-Sobrido

Publikováno v: Microbiology Spectrum. 10

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the highly contagious agent responsible for the coronavirus disease 2019 (COVID-19) pandemic. An essential requirement for understanding SARS-CoV-2 fundamental biology and the impact of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578cdf2af0497f701b7701585e26d98f
https://doi.org/10.1128/spectrum.02379-22

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Structure and Epitope of a Neutralizing Monoclonal Antibody that Targets the Stem Helix of β Coronaviruses

Autor: Ashlesha Deshpande, Nobert Schormann, Mike S. Piepenbrink, Luis Martinez Sobrido, James J. Kobie, Mark R. Walter

Monoclonal antibodies (MAbs) that retain neutralizing activity against distinct coronavirus (CoV) lineages and variants of concern (VoC) must be developed to protect against future pandemics. These broadly neutralizing MAbs (BNMAbs) may be used as th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7b9fe82a8348e7c6453a33d0188fee
https://doi.org/10.1101/2022.09.14.507947

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