Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mark R Slaughter"'
Autor:
Mark R Slaughter, Bela Rajiv Patel, Heather L. Lloyd, Greg Whelan, Janette A. Osborne, Joanne Byrne, David Templeton, Karen Pointing, David G. Reid, Alan White, Albert L. Busza, Belinda A. Farnfield, Gemma L. Taylor, Paul D. Hockings, Sean C. Smart, Jeffrey M. Birmingham, Ana Criado-Gonzalez, Axel Krebs-Brown
Publikováno v:
Toxicology Mechanisms and Methods. 13:39-43
The use of magnetic resonance imaging (MRI) for the measurement of cardiac output parameters in anesthetized adult male beagle dogs has been validated against a widely accepted thermodilution method. Using a multislice cine gradient echo MRI method t
Publikováno v:
Current Eye Research. 26:15-23
Various animal species have been used to study oxidative stress-induced cataractogenesis; however, given that differences in the expression of the lens antioxidant system may influence species susceptibility to oxidative stress, we compared and contr
Autor:
Mark R Slaughter, J. S. Moen
Publikováno v:
Laboratory Animals. 25:272-276
Blood specimens from the retro-orbital sinus of 80 Sprague Dawley rats were collected into tubes containing lithium heparin either as a solid or an aqueous solution. Plasma was separated for blood chemistry analysis. Twenty-eight blood specimens coll
Publikováno v:
Toxicology in Vitro. 13:567-569
Alamar Blue (AB) reduction is a promising new in vitro assay which is simple to conduct and amenable to repeated measurements and high-throughput screening; however, evaluation with hepatocytes has not been reported. Accordingly, we compared AB reduc
Autor:
J. A. Osborne, Mark R Slaughter, Bela Rajiv Patel, Greg Whelan, Paul D. Hockings, Jeffrey M. Birmingham, Axel Krebs-Brown
Publikováno v:
Laboratory animals. 36(4)
Important in all experimental animal studies is the need to control stress stimuli associated with environmental change and experimental procedures. As the stress response involves alterations in levels of vasoactive hormones, ensuing changes in card
Publikováno v:
Laboratory animals. 36(3)
In a recent study in rats, alanine aminotransferase (ALT), the preferred plasma biomarker of hepatocellular injury in rats, was ineffective at detecting marked hepatic necrosis produced by acetaminophen ( Human and Experimental Toxicology 19, 277-83,
Publikováno v:
Toxicology and applied pharmacology. 178(2)
Oxidative stress elicits an adaptive antioxidant response, which varies with tissue type. Diquat, a potent redox cycler that generates reactive oxygen species, has been used to study oxidative stress; however, its effect on the antioxidant system has
Autor:
Mark R Slaughter, Peter J. O'Brien
Publikováno v:
Clinical biochemistry. 33(7)
Objectives: Develop fully automated assay of antioxidant catalatic activity of catalase. Design and methods: The assay is based on standard, clinical chemistry automated analyzer methods for measuring hydrogen peroxide by using the Trinder reagent. C
Autor:
F Elcock, J M Birmingham, Peter J. O'Brien, P J Bugelski, A Swain, Mark R Slaughter, R W Greenhill
Publikováno v:
Humanexperimental toxicology. 19(5)
Repeated dosing of acetaminophen (paracetamol) to rats is reported to decrease their sensitivity to its hepatotoxic effects, which are associated with oxidative stress and glutathione depletion. We determined if repeated acetaminophen dosing produced