Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mark R P, Aurousseau"'
Autor:
Rikard Blunck, Filip Liebsch, Gerd Multhaup, Silvia Scolari, Tobias Bethge, Hugo McGuire, Derek Bowie, Mark R. P. Aurousseau, Andreas Herrmann
Publikováno v:
Journal of Biological Chemistry. 292:13258-13270
The β-secretase (BACE1) initiates processing of the amyloid precursor protein (APP) into Aβ peptides, which have been implicated as central players in the pathology of Alzheimer disease. BACE1 has been described as a copper-binding protein and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e2dbb3a70c9321dc90a77c81ff8bdf
https://doi.org/10.1074/jbc.m117.779165
https://doi.org/10.1074/jbc.m117.779165
Autor:
Mohammad Fahim Kadir, Camilo Navarrete, Christian Fuentes, R. Venskutonyte, M. Arsenault, Amanda M Perozzo, E.A. Santander, Y. Yan, John Michael Edwardson, Ryan P.D. Alexander, Derek Bowie, Jette S. Kastrup, Mark R. P. Aurousseau, Karla Frydenvang, Nelson P. Barrera, George B. Dawe
Publikováno v:
Neuron. 102(5)
Summary Neurotransmitter-gated ion channels are allosteric proteins that switch on and off in response to agonist binding. Most studies have focused on the agonist-bound, activated channel while assigning a lesser role to the apo or resting state. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb58497e10f5d2bfe9e6643645fecd31
https://pubmed.ncbi.nlm.nih.gov/31053408
https://pubmed.ncbi.nlm.nih.gov/31053408
Publikováno v:
The Journal of Physiology. 593:97-110
Ionotropic glutamate receptors (iGluRs) are the major excitatory neurotransmitter receptor in the vertebrate CNS and, as a result, their activation properties lie at the heart of much of the neuronal network activity observed in the developing and ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e4a8ce398a5ecb76e11f5eec170237f
https://doi.org/10.1113/jphysiol.2014.277921
https://doi.org/10.1113/jphysiol.2014.277921
Autor:
Derek Bowie, Michael V. Accardi, Mark R. P. Aurousseau, Bryan A. Daniels, Elizabeth D. Andrews
Publikováno v:
The Journal of Physiology. 591:3873-3885
Key points • This study identifies the gating structure responsible for controlling ion-channel subconductance behaviour at a major neurotransmitter receptor, namely kainate-type ionotropic glutamate receptor. • Evidence is provided that the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d88d96c39b6a59bfa5ac2fb75018b933
https://doi.org/10.1113/jphysiol.2013.253666
https://doi.org/10.1113/jphysiol.2013.253666
Autor:
Maria Musgaard, Derek Bowie, Mark R. P. Aurousseau, Elizabeth D. Andrews, Bryan A. Daniels, George B. Dawe, Philip C. Biggin
Glutamate is the major excitatory neurotransmitter in the brain, activating ionotropic receptors named for their selectivity to the agonists NMDA, AMPA, and kainate (KARs). The KAR subunit GluK2 requires external ions, in addition to glutamate, to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31fc6f9bf95a5f690af8eccab126748
https://ora.ox.ac.uk/objects/uuid:cbb20fad-d794-41b8-968d-0be17447fb9c
https://ora.ox.ac.uk/objects/uuid:cbb20fad-d794-41b8-968d-0be17447fb9c
Autor:
Teresa Paramo, Maria Musgaard, Philip C. Biggin, Derek Bowie, Mark R. P. Aurousseau, Patricia M.G.E. Brown
Publikováno v:
Biophysical Journal. 110(3)
Ionotropic glutamate receptors (iGluRs) mediate most of the excitatory synaptic neurotransmission, controlling synaptic strength and plasticity, aspects which are thought to underlay learning and memory. These ligand-gated ion channels are classified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5268b8eab225afa924e46da27f777515
Publikováno v:
Ionotropic Glutamate Receptor Technologies ISBN: 9781493928118
Determining the composition and stoichiometry of membrane-bound proteins has been a perennial problem that has plagued biology for a long time. The most recurring issue is that composition and subunit stoichiometry is commonly inferred from bulk bioc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95e6348cb042be65139320f2d7a35282
https://doi.org/10.1007/978-1-4939-2812-5_2
https://doi.org/10.1007/978-1-4939-2812-5_2
Publikováno v:
European Journal of Neuroscience. 35:1201-1207
Ca(2+) and/or Zn(2+) entry into neurons and glial cells is often a key step driving the processes of neurodevelopment and disease. As a result, a major pre-occupation of many neuroscientists has been in tracking down when and where nervous tissues ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::331cc8206c327b70afdaf98af3b81c59
https://doi.org/10.1111/j.1460-9568.2012.08042.x
https://doi.org/10.1111/j.1460-9568.2012.08042.x
Autor:
Derek Bowie, Mark R. P. Aurousseau, Philip A. Barker, Jorge L. Cueva Vargas, Ingrid K. Osswald, Nicolas Unsain, Adriana Di Polo
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Loss of vision in glaucoma results from the selective death of retinal ganglion cells (RGCs). Tumor necrosis factor α (TNFα) signaling has been linked to RGC damage, however, the mechanism by which TNFα promotes neuronal death remains poorly defin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46800c706d0cc8af56e502b673829800
http://www.jneurosci.org/content/35/35/12088
http://www.jneurosci.org/content/35/35/12088
Publikováno v:
Biophysical Journal. 108(2)
Ionotropic glutamate receptors (iGluRs) facilitate the bulk of synaptic excitation in the mammalian central nervous system. Structures of full-length, AMPA-type iGluRs (AMPARs) have recently been reported in conformations thought to represent resting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16eeb8564974e3c3c76e11ba64580815