Zobrazeno 1 - 10
of 270
pro vyhledávání: '"Mark R, Viant"'
Autor:
Arthur de Carvalho e Silva, George D. Loizou, Kevin McNally, Olivia Osborne, Claire Potter, David Gott, John K. Colbourne, Mark R. Viant
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant that can accumulate in the human body due to its long half-life. This substance has been associated with liver, pancreatic, testicular and breast cancers, liver steatosis and end
Externí odkaz:
https://doaj.org/article/fd5a6987abd5448fb0bae9679c5000ab
Autor:
Tara J. Bowen, Andrew D. Southam, Andrew R. Hall, Ralf J. M. Weber, Gavin R. Lloyd, Ruth Macdonald, Amanda Wilson, Amy Pointon, Mark R. Viant
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its biotransformation products as part of the metabolomics analysis provi
Externí odkaz:
https://doaj.org/article/4910e9a54ea449d1b77c4b11d29fc8ec
Autor:
Kieran A. Bates, Ulf Sommer, Kevin P. Hopkins, Jennifer M. G. Shelton, Claudia Wierzbicki, Christopher Sergeant, Benjamin Tapley, Christopher J. Michaels, Dirk S. Schmeller, Adeline Loyau, Jaime Bosch, Mark R. Viant, Xavier A. Harrison, Trenton W. J. Garner, Matthew C. Fisher
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract Background The fungal pathogen Batrachochytrium dendrobatidis (Bd) threatens amphibian biodiversity and ecosystem stability worldwide. Amphibian skin microbial community structure has been linked to the clinical outcome of Bd infections, yet
Externí odkaz:
https://doaj.org/article/3524a32f17ad4dacbe2e7df9426a4c9d
Autor:
James B. Brown, Sasha A. Langley, Antoine M. Snijders, Kenneth H. Wan, Siti Nur Sarah Morris, Benjamin W. Booth, William W. Fisher, Ann S. Hammonds, Soo Park, Richard Weiszmann, Charles Yu, Jennifer A. Kirwan, Ralf J. M. Weber, Mark R. Viant, Jian-Hua Mao, Susan E. Celniker
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Brown et al. apply integrated omics and phenotypic screening to assess the role of the gut microbiome in modulating host resilience in Drosophila melanogaster. They find that Acetobacter tropicalis in gnotobiotic animals, is sufficient to rescue incr
Externí odkaz:
https://doaj.org/article/c3ab3d12ed36490693a2a628de744736
Autor:
John K. Colbourne, Joseph R. Shaw, Elena Sostare, Claudia Rivetti, Romain Derelle, Rosemary Barnett, Bruno Campos, Carlie LaLone, Mark R. Viant, Geoff Hodges
Publikováno v:
Environmental Advances, Vol 9, Iss , Pp 100287- (2022)
Toxicology is traditionally divided between human and eco-toxicology. In the shared pursuit of environmental health, this separation does not account for discoveries made in the comparative studies of animal genomes. Here, we provide evidence on the
Externí odkaz:
https://doaj.org/article/c895c46d8de940a698204276b1472775
Autor:
Jaanika Kronberg, Jonathan J. Byrne, Jeroen Jansen, Philipp Antczak, Adam Hines, John Bignell, Ioanna Katsiadaki, Mark R. Viant, Francesco Falciani
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The monitoring of anthropogenic chemicals in the aquatic environment including their potential effects on aquatic organisms, is important for protecting life under water, a key sustainable development goal. In parallel with monitoring the co
Externí odkaz:
https://doaj.org/article/482d7638e4254c6588d577da7644f49b
Autor:
Mark R. Viant, Timothy M. D. Ebbels, Richard D. Beger, Drew R. Ekman, David J. T. Epps, Hennicke Kamp, Pim E. G. Leonards, George D. Loizou, James I. MacRae, Bennard van Ravenzwaay, Philippe Rocca-Serra, Reza M. Salek, Tilmann Walk, Ralf J. M. Weber
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Lack of best practice guidelines currently limits the application of metabolomics in the regulatory sciences. Here, the MEtabolomics standaRds Initiative in Toxicology (MERIT) proposes methods and reporting standards for several important application
Externí odkaz:
https://doaj.org/article/4701db2695034f70a507e741b7841422
Autor:
Michael Sweet, Mark Bulling, Dorsa Varshavi, Gavin R. Lloyd, Andris Jankevics, Lukáš Najdekr, Ralf J. M. Weber, Mark R. Viant, Jamie Craggs
Publikováno v:
Frontiers in Marine Science, Vol 8 (2021)
Coral reefs are suffering unprecedented declines in health state on a global scale. Some have suggested that human assisted evolution or assisted gene flow may now be necessary to effectively restore reefs and pre-condition them for future climate ch
Externí odkaz:
https://doaj.org/article/cae140300cef498691cb7c5fef9f042c
Publikováno v:
Metabolites, Vol 12, Iss 1, p 33 (2022)
Untargeted lipidomics has previously been applied to the study of daphnids and the discovery of biomarkers that are indicative of toxicity. Typically, liquid chromatography—mass spectrometry is used to measure the changes in lipid abundance in whol
Externí odkaz:
https://doaj.org/article/d4a3717de15a4d52b8c45cd469140806
Autor:
Julia M. Malinowska, Taina Palosaari, Jukka Sund, Donatella Carpi, Gavin R. Lloyd, Ralf J. M. Weber, Maurice Whelan, Mark R. Viant
Publikováno v:
Metabolites, Vol 12, Iss 1, p 52 (2022)
Regulatory bodies have started to recognise the value of in vitro screening and metabolomics as two types of new approach methodologies (NAMs) for chemical risk assessments, yet few high-throughput in vitro toxicometabolomics studies have been report
Externí odkaz:
https://doaj.org/article/94462e96c0024fd68ed3af5b611bcd89