Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Mark R, Silvis"'
1
Akademický článek
Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer
Autor: Phaedra C Ghazi, Kayla T O'Toole, Sanjana Srinivas Boggaram, Michael T Scherzer, Mark R Silvis, Yun Zhang, Madhumita Bogdan, Bryan D Smith, Guillermina Lozano, Daniel L Flynn, Eric L Snyder, Conan G Kinsey, Martin McMahon
Publikováno v: eLife, Vol 13 (2024)
Mutational activation of KRAS occurs commonly in lung carcinogenesis and, with the recent U.S. Food and Drug Administration approval of covalent inhibitors of KRASG12C such as sotorasib or adagrasib, KRAS oncoproteins are important pharmacological ta
Externí odkaz: https://doaj.org/article/95323d71411b4fb5a507d99214305120
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2
Akademický článek
Mutant IDH1 Promotes Glioma Formation In Vivo
Autor: Beatrice Philip, Diana X. Yu, Mark R. Silvis, Clifford H. Shin, James P. Robinson, Gemma L. Robinson, Adam E. Welker, Stephanie N. Angel, Sheryl R. Tripp, Joshua A. Sonnen, Matthew W. VanBrocklin, Richard J. Gibbons, Ryan E. Looper, Howard Colman, Sheri L. Holmen
Publikováno v: Cell Reports, Vol 23, Iss 5, Pp 1553-1564 (2018)
Summary: Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated gene in grade II–III glioma and secondary glioblastoma (GBM). A causal role for IDH1R132H in gliomagenesis has been proposed, but functional validation in vivo has not been dem
Externí odkaz: https://doaj.org/article/2d92767aaa004267a8ec8cf27e3f8ef6
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5
MYC-mediated resistance to trametinib and HCQ in PDAC is overcome by CDK4/6 and lysosomal inhibition
Autor: Mark R. Silvis, Dilru Silva, Riley Rohweder, Sophia Schuman, Swapna Gudipaty, Amanda Truong, Jeffrey Yap, Kajsa Affolter, Martin McMahon, Conan Kinsey
Publikováno v: Journal of Experimental Medicine. 220
Pharmacological inhibition of KRAS>RAF>MEK1/2>ERK1/2 signaling has provided no clinical benefit to patients with pancreatic ductal adenocarcinoma (PDAC). Interestingly, combined inhibition of MEK1/2 (with trametinib [T]) plus autophagy (with chloroqu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e0d3f476b2a19db13db0b66347be1b4
https://doi.org/10.1084/jem.20221524
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6
Resistance mechanisms to genetic suppression of mutant NRAS in melanoma
Autor: Douglas Grossman, Geoffrey T. Gibney, Keiran S.M. Smalley, Vito W. Rebecca, Mark R. Silvis, Kristin J. Lastwika, James P. Robinson, Inna Smalley, David A. Kircher, Michael A. Davies, Matthew W. VanBrocklin, Sheri L. Holmen, Guo Chen
Publikováno v: Melanoma Research. 27:545-557
Targeted therapies have revolutionized cancer care, but the development of resistance remains a challenge in the clinic. To identify rational targets for combination strategies, we used an established melanoma mouse model and selected for resistant t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ccb4fa57be47e17845dfb43619a733
https://doi.org/10.1097/cmr.0000000000000403
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7
AKT1
Autor: David A, Kircher, Kirby A, Trombetti, Mark R, Silvis, Gennie L, Parkman, Grant M, Fischer, Stephanie N, Angel, Christopher M, Stehn, Sean C, Strain, Allie H, Grossmann, Keith L, Duffy, Kenneth M, Boucher, Martin, McMahon, Michael A, Davies, Michelle C, Mendoza, Matthew W, VanBrocklin, Sheri L, Holmen
Publikováno v: Mol Cancer Res
Alterations in the PI3K/AKT pathway occur in up to 70% of melanomas and are associated with disease progression. The three AKT paralogs are highly conserved but data suggest they have distinct functions. Activating mutations of AKT1 and AKT3 occur in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7f27bf26cb8933dafd9c5cde8da3a09
https://pubmed.ncbi.nlm.nih.gov/31138602
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8
Abstract 2736: AKT1E17K activates focal adhesion kinase and promotes melanoma brain metastasis
Autor: Mark R. Silvis, Sheri L. Holmen, Sean C. Strain, Stephanie N. Angel, Matthew W. VanBrocklin, Kirby A. Trombetti, David A. Kircher, Christopher M. Stehn, Michael A. Davies, Allie H. Grossmann, Grant M. Fischer, Michelle C. Mendoza, Gennie L. Parkman, Keith L. Duffy, Martin McMahon
Publikováno v: Cancer Research. 80:2736-2736
Hyper-activation of the PI3K/AKT signaling pathway occurs in most metastatic melanomas and increased PI3K/AKT pathway activity correlates with disease progression. The serine/threonine kinase, AKT, represents a major signaling hub within the pathway
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de04a780981961d88b62e5a3a08d8c1c
https://doi.org/10.1158/1538-7445.am2020-2736
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9
Abstract C30: Myc amplification is a negative biomarker and a resistance mechanism to trametinib/HCQ treatment, but can be overcome by combined palbociclib/HCQ treatment
Autor: Sophia S. Schuman, Kajsa E. Affolter, Mark R. Silvis, Dilru Silva, Conan Kinsey, Martin McMahon
Publikováno v: Cancer Research. 79:C30-C30
Pancreatic ductal adenocarcinoma (PDAC) is a recalcitrant disease responsible for ~43,000 deaths in the USA in 2017. Despite an advanced understanding of the genetics, biochemistry, and biology of pancreatic cancer, there is no effective pathway-targ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e62e585f6d8c2ffe3d3a1838ee9f2934
https://doi.org/10.1158/1538-7445.panca19-c30
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10
PittGrub
Autor: Anthony Sicilia, Mark R. Silvis, Alexandros Labrinidis
Publikováno v: KDD
The amount of food waste generated by the U.S. is staggering, both expensive in economic cost and environmental side effects. Surplus food, which could be used to feed people facing food insecurity, is instead discarded and placed in landfills. Insti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bfb471d90ad4301bc341d2844e66f1e
https://doi.org/10.1145/3219819.3219836
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