Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Mark R, Segal"'
Autor:
Ruth F. Dubin, Rajat Deo, Yue Ren, Jianqiao Wang, Zihe Zheng, Haochang Shou, Alan S. Go, Afshin Parsa, James P. Lash, Mahboob Rahman, Chi-yuan Hsu, Matthew R. Weir, Jing Chen, Amanda Anderson, Morgan E. Grams, Aditya Surapaneni, Josef Coresh, Hongzhe Li, Paul L. Kimmel, Ramachandran S. Vasan, Harold Feldman, Mark R. Segal, Peter Ganz, CRIC Study Investigators, CKD Biomarkers Consortium
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Progression of chronic kidney disease (CKD) portends myriad complications, including kidney failure. In this study, we analyze associations of 4638 plasma proteins among 3235 participants of the Chronic Renal Insufficiency Cohort Study with
Externí odkaz:
https://doaj.org/article/e4b35c37bd9f4b68928efff3e22388ac
Autor:
Adam B. Olshen, Mark R. Segal
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background Methods for inferring the three-dimensional (3D) configuration of chromatin from conformation capture assays that provide strictly pairwise interactions, notably Hi-C, utilize the attendant contact matrix as input. More recent ass
Externí odkaz:
https://doaj.org/article/06abc9cb951642bca86c1aaa654f297e
Autor:
Mark R. Segal, Kipper Fletez-Brant
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background The spatial configuration of chromosomes is essential to various cellular processes, notably gene regulation, while architecture related alterations, such as translocations and gene fusions, are often cancer drivers. Thus, eliciti
Externí odkaz:
https://doaj.org/article/b2f7ffffb4e742b2ba50d311b051cf4a
Autor:
Semira Gonseth, Gary M. Shaw, Ritu Roy, Mark R. Segal, Kripa Asrani, Jasper Rine, Joseph Wiemels, Nicholas J. Marini
Publikováno v:
Epigenetics, Vol 14, Iss 2, Pp 198-213 (2019)
Cleft lip with or without cleft palate (CL/P) is a common human birth defect whose etiologies remain largely unknown. Several studies have demonstrated that periconceptional supplementation of folic acid can reduce risk of CL/P in offspring. In this
Externí odkaz:
https://doaj.org/article/a44c6ec8b0b940e9b45c59b522f17f40
Autor:
Ruth F Dubin, Rajat Deo, Yue Ren, Hongzhe Lee, Haochang Shou, Harold Feldman, Paul Kimmel, Sushrut S Waikar, Eugene P Rhee, Adrienne Tin, Jingsha Chen, Joseph Coresh, Alan S Go, Tanika Kelly, Paduranga S Rao, Teresa K Chen, Mark R Segal, Peter Ganz
Publikováno v:
The Journal of Applied Laboratory Medicine. 8:491-503
Background We carried out a study of the aptamer proteomic assay, SomaScan V4, to evaluate the analytical and biological variability of the assay in plasma samples of patients with moderate to severe chronic kidney disease (CKD). Methods Plasma sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab68292199ac6d41ca5f528aef7f33ae
https://doi.org/10.1093/jalm/jfac145
https://doi.org/10.1093/jalm/jfac145
Autor:
Philip L Ballard, Juan Oses-Prieto, Cheryl Chapin, Mark R Segal, Roberta A Ballard, Alma L Burlingame
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243168 (2020)
BackgroundInfants born at extremely low gestational age are at high risk for bronchopulmonary dysplasia and continuing lung disease. There are no early clinical biomarkers for pulmonary outcome and limited therapeutic interventions.ObjectivesWe perfo
Externí odkaz:
https://doaj.org/article/0905d1b78e6348cfa572293fd125b6ed
Autor:
Mark R. Segal, Henrik L. Bengtsson
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-9 (2018)
Abstract Background Three dimensional (3D) genome spatial organization is critical for numerous cellular functions, including transcription, while certain conformation-driven structural alterations are frequently oncogenic. Genome conformation had be
Externí odkaz:
https://doaj.org/article/2b8026b67c2347e4b1b9148f1ac9ccd2
Autor:
Rajat Deo, Ruth F Dubin, Yue Ren, Ashwin C Murthy, Jianqiao Wang, Haotian Zheng, Zihe Zheng, Harold Feldman, Haochang Shou, Josef Coresh, Morgan Grams, Aditya L Surapaneni, Zeenat Bhat, Jordana B Cohen, Mahboob Rahman, Jiang He, Santosh L Saraf, Alan S Go, Paul L Kimmel, Ramachandran S Vasan, Mark R Segal, Hongzhe Li, Peter Ganz
Publikováno v:
European Heart Journal.
Aims Chronic kidney disease (CKD) is widely prevalent and independently increases cardiovascular risk. Cardiovascular risk prediction tools derived in the general population perform poorly in CKD. Through large-scale proteomics discovery, this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59c29b694b223f2b0aa74f2bfbb808aa
https://doi.org/10.1093/eurheartj/ehad115
https://doi.org/10.1093/eurheartj/ehad115
Autor:
Robert J. Blount, Mark R. Segal, Ha Phan, Joseph Zabner, Emma M. Stapleton, Michael Zavala, Trang D Trinh, Nguyen Viet Nhung, Hai Dang, Payam Nahid, Alejandro P. Comellas, John R. Balmes, Cindy Merrifield
Publikováno v:
American journal of respiratory and critical care medicine, vol 204, iss 10
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine
Rationale: The Southeast Asian tuberculosis burden is high, and it remains unclear if urban indoor air pollution in this setting is exacerbating the epidemic. Objectives: To determine the associations of latent tuberculosis with common urban indoor a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4065353cff6e825fb643a90bcba164e3
https://doi.org/10.1164/rccm.202101-0136oc
https://doi.org/10.1164/rccm.202101-0136oc
Autor:
Kim Stanley, Amy Nichols, Renee Graham-Ojo, Lusha Wang, Catherine DeVoe, Rajani Ghale, Sharline Madera, Joe Fan, Priya A. Prasad, Sarah L. Patterson, Kirsten N. Kangelaris, Deborah S. Yokoe, Yumiko Abe-Jones, Jonathan Schouest, Mark R. Segal, Christina Love, Charles Langelier
Publikováno v:
Infection Control and Hospital Epidemiology
Infection control and hospital epidemiology, vol 43, iss 10
Infection control and hospital epidemiology, vol 43, iss 10
Objective:We compared the rates of hospital-onset secondary bacterial infections in patients with coronavirus disease 2019 (COVID-19) with rates in patients with influenza and controls, and we investigated reports of increased incidence of Enterococc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6114e5e41ad3d09687f2d791853e3788
https://doi.org/10.1017/ice.2021.391
https://doi.org/10.1017/ice.2021.391