Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Mark R, Philips"'
Autor:
Jian-Gang Ren, Bowen Xing, Kaosheng Lv, Rachel A. O’Keefe, Mengfang Wu, Ruoxing Wang, Kaylyn M. Bauer, Arevik Ghazaryan, George M. Burslem, Jing Zhang, Ryan M. O’Connell, Vinodh Pillai, Elizabeth O. Hexner, Mark R. Philips, Wei Tong
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
RAS mutations are among the most prevalent oncogenic drivers in cancers. RAS proteins propagate signals only when associated with cellular membranes as a consequence of lipid modifications that impact their trafficking. Here, we discovered that RAB27
Externí odkaz:
https://doaj.org/article/636f9f226afa48728696c139c7a0044c
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The three mammalian RAS genes (HRAS, NRAS and KRAS) encode four proteins that play central roles in cancer biology. Among them, KRAS is mutated more frequently in human cancer than any other oncogene. The pre-mRNA of KRAS is alternatively spliced to
Externí odkaz:
https://doaj.org/article/cf8a28130def4bb5aad25b35e19e2553
Autor:
Seth J. Parker, Joel Encarnación-Rosado, Kate E. R. Hollinshead, David M. Hollinshead, Leonard J. Ash, Juan A. K. Rossi, Elaine Y. Lin, Albert S. W. Sohn, Mark R. Philips, Drew R. Jones, Alec C. Kimmelman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Analogues of α-ketoglutarate are used in many cellular studies but assumptions are made about cellular uptake. Here, the authors show that esterified analogues rapidly hydrolyse in aqueous medium resulting in an analogue which can be quickly taken u
Externí odkaz:
https://doaj.org/article/a430c84ac3014555b5b20af966982f02
Autor:
Antonio García-España, Mark R. Philips
Publikováno v:
Oncogene. 42:1741-1750
Publikováno v:
Molecular Cell. 83:1210-1215
Autor:
Xue Chen, Haidong Yao, Muhammad Kashif, Gwladys Revêchon, Maria Eriksson, Jianjiang Hu, Ting Wang, Yiran Liu, Elin Tüksammel, Staffan Strömblad, Ian M Ahearn, Mark R Philips, Clotilde Wiel, Mohamed X Ibrahim, Martin O Bergo
Publikováno v:
eLife, Vol 10 (2021)
A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford progeria syndrome (HGPS). Inhibiting progerin methylation by inactivating the isoprenylcysteine carboxylmethyltransferase (ICMT) gene stimulates proliferation
Externí odkaz:
https://doaj.org/article/af9f4ea451d04c5cba3ce05449cb18c3
Publikováno v:
Biochemical Society Transactions.
RAS proteins are small GTPases that transduce signals from membrane receptors to signaling pathways that regulate growth and differentiation. Four RAS proteins are encoded by three genes — HRAS, KRAS, NRAS. Among them, KRAS is mutated in human canc
Autor:
Alec C. Kimmelman, Joseph D. Mancias, Dafna Bar-Sagi, Mark R. Philips, Huamin Wang, Drew R. Jones, Steven P. Gygi, Joao A. Paulo, Doug E. Biancur, Albert S.W. Sohn, Madeleine M. LaRue, Rebecca E. Rose, Joel Encarnación-Rosado, Keisuke Yamamoto, Qijia Yu, Kate E.R. Hollinshead, Caroline R. Amendola, Seth J. Parker
Pancreatic ductal adenocarcinoma (PDAC) evolves a complex microenvironment comprised of multiple cell types, including pancreatic stellate cells (PSC). Previous studies have demonstrated that stromal supply of alanine, lipids, and nucleotides support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d4144fd59409f3ac6db0c6f0233288
https://doi.org/10.1158/2159-8290.c.6547766.v1
https://doi.org/10.1158/2159-8290.c.6547766.v1
Autor:
Nicole Fehrenbacher, Mark R. Philips
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)
Effective anti-rat sarcoma viral oncogene (RAS) therapies have remained the holy grail of cancer treatment. Mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) sustains tumorigenesis when linked to the plasma membrane (PM). The G protein-coupled
Externí odkaz:
https://doaj.org/article/e63e523585c14ce999cc34eef987222f
Autor:
Joseph D. Mancias, Seth J. Parker, Mark R. Philips, Drew R. Jones, Alec C. Kimmelman, Doug E. Biancur, Steven P. Gygi, Joao A. Paulo, Qijia Yu, Albert S. W. Sohn, Kate E.R. Hollinshead, Keisuke Yamamoto, Rebecca E. Rose, Joel Encarnación-Rosado, Madeleine M. LaRue, Caroline R. Amendola, Huamin Wang, Dafna Bar-Sagi
Publikováno v:
Cancer Discov
Pancreatic ductal adenocarcinoma (PDAC) evolves a complex microenvironment comprised of multiple cell types, including pancreatic stellate cells (PSC). Previous studies have demonstrated that stromal supply of alanine, lipids, and nucleotides support