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B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Rational development of successful vaccines requires utilization of predictive models of vaccination. One approach for development of an HIV vaccine has been to study broadly neutralizing antibodies (bnAbs) and revert the mutations back

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036d3f5439a4f5af285f5261a83e0d6d
http://europepmc.org/articles/PMC7502816

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Abstract 17233: Primary Intimal Sarcoma Of The Pulmonary Artery In A Patient With Laboratory Confirmed Heterozygous Factor V Leiden Mutation: A Case Report

Autor: Mark Pintea, Melody Hermel, Sandeep Mehta, Curtiss Stinis, Rajeev Mohan, Ajay Srivastava

Publikováno v: Circulation. 144

Pulmonary artery intimal sarcoma (PAIS) is a rare tumor associated with progressively increasing dyspnea, atypical chest pain, and pulmonary hypertension. Owing to overlap in presentation, PAIS can be misdiagnosed as pulmonary thromboembolism (PTE).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a16f348a99c44dfe3a1bef02e2930034
https://doi.org/10.1161/circ.144.suppl_2.17233

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B cells expressing authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple independent mouse models

Animal models of human antigen-specific B cell receptors (BCR) generally depend on “inferred germline” sequences, and thus their relationship to authentic naive human B cell BCR sequences and affinities is unclear. Here, BCR sequences from authen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d72c29cd9b88b2c87cd71c7c5933bf

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