Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Mark Petrash"'
Publikováno v:
PLoS ONE, Vol 16, Iss 12 (2021)
Introduction Cerebrospinal fluid (CSF) outflow has been demonstrated along nasal lymphatics via olfactory nerve projections; flow may be increased by stimulating lymphatic contractility using agents such as noradrenaline and the thromboxane A2 analog
Externí odkaz:
https://doaj.org/article/c38bb7a1461445409e50e2dc583203b9
Nano-assemblies enhance chaperone activity, stability, and delivery of alpha B-crystallin-D3 (αB-D3)
Publikováno v:
Journal of Controlled Release. 352:411-421
Crystallins, small heat shock chaperone proteins that prevent protein aggregation, are of potential value in treating protein aggregation disorders. However, their therapeutic use is limited by their low potency and poor intracellular delivery. One a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e87606544f6ef60cb5bb815f4fab61
https://doi.org/10.1016/j.jconrel.2022.10.026
https://doi.org/10.1016/j.jconrel.2022.10.026
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1150 (2021)
Cataracts are a leading cause of blindness worldwide. Surgical removal of cataracts is a safe and effective procedure to restore vision. However, a large number of patients later develop vision loss due to regrowth of lens cells and subsequent degrad
Externí odkaz:
https://doaj.org/article/c0631db6fbd34880b6395378b797a155
Publikováno v:
Metabolites, Vol 11, Iss 7, p 450 (2021)
Aldose reductase (AR), the first and rate-limiting enzyme of the polyol pathway, has been implicated in the onset and development of the ocular complications of diabetes, including cataracts and retinopathy. Despite decades of research conducted to a
Externí odkaz:
https://doaj.org/article/442620712d104a0c9d6576385511f12e
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191025 (2018)
Diabetes mellitus is a chronic disease that is becoming a serious global health problem. Diabetes has been considered to be one of the major risks of cataract and retinopathy. Synthetic and natural product inhibitors of carbohydrate degrading enzymes
Externí odkaz:
https://doaj.org/article/bfaab934e4044aa9b33302a5d37352ab
Akademický článek
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Autor:
Chandrasekhar Akileshwari, Ganugula Raghu, Puppala Muthenna, Niklaus H. Mueller, Palla Suryanaryana, J. Mark Petrash, G. Bhanuprakash Reddy
Publikováno v:
Journal of Functional Foods, Vol 6, Iss , Pp 374-383 (2014)
Accumulation of intracellular sorbitol due to increased aldose reductase (AR or ALR2) activity is one of the pathways implicated in the development of long-term diabetic complications. In the present study, we described the inhibition of ALR2 by ella
Externí odkaz:
https://doaj.org/article/2fddeb1686cf478ea9e6f505e7d68c5e
Autor:
Okoyeocha OM. Ebenezar, Andrew Roney, Dinesh G. Goswami, J. Mark Petrash, Dodd Sledge, András M. Komáromy, Karen T. Liby, Neera Tewari-Singh
Publikováno v:
Experimental Eye Research. 230:109440
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58509bacce5283fb7a4b4e02ee2f9066
https://doi.org/10.1016/j.exer.2023.109440
https://doi.org/10.1016/j.exer.2023.109440
Autor:
J. Mark Petrash, Vasilis Vasiliou
Publikováno v:
Chemico-biological interactions. 363
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16b8d81075f84209cd3a2b75cf8ac6c
https://pubmed.ncbi.nlm.nih.gov/35662544
https://pubmed.ncbi.nlm.nih.gov/35662544
Autor:
Niklaus H Mueller, Uma Fogueri, Michelle G Pedler, Kameron Montana, J Mark Petrash, David A Ammar
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137659 (2015)
Misfolded protein aggregation, including cataract, cause a significant amount of blindness worldwide. α-Crystallin is reported to bind misfolded proteins and prevent their aggregation. We hypothesize that supplementing retina and lens with α-crysta
Externí odkaz:
https://doaj.org/article/b0ee6cfd8adf4645998826edd0cecb0c