Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Mark P. Kühnel"'
Autor:
Natali Froese, Malgorzata Szaroszyk, Paolo Galuppo, Joseph R. Visker, Christopher Werlein, Mortimer Korf‐Klingebiel, Dominik Berliner, Marc R. Reboll, Rana Hamouche, Simona Gegel, Yong Wang, Winfried Hofmann, Ming Tang, Robert Geffers, Adam R. Wende, Mark P. Kühnel, Danny D. Jonigk, Georg Hansmann, Kai C. Wollert, E. Dale Abel, Stavros G. Drakos, Johann Bauersachs, Christian Riehle
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 3 (2024)
Background Alveolar hypoxia is protective in the context of cardiovascular and ischemic heart disease; however, the underlying mechanisms are incompletely understood. The present study sought to test the hypothesis that hypoxia is cardioprotective in
Externí odkaz:
https://doaj.org/article/faab23b5566643d4bb708c9cafa2f8de
Autor:
Ivanna Shymotiuk, Natali Froese, Christopher Werlein, Lea Naasner, Malgorzata Szaroszyk, Mark P. Kühnel, Danny D. Jonigk, William S. Blaner, Adam R. Wende, E. Dale Abel, Johann Bauersachs, Christian Riehle
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundPerturbed mitochondrial energetics and vitamin A (VitA) metabolism are associated with the pathogenesis of diet-induced obesity (DIO) and type 2 diabetes (T2D).MethodsTo test the hypothesis that VitA regulates tissue-specific mitochondrial
Externí odkaz:
https://doaj.org/article/a7b8334c47324bfbb1423d724828512f
Autor:
Maximilian Ackermann, Jan C. Kamp, Christopher Werlein, Claire L. Walsh, Helge Stark, Verena Prade, Rambabu Surabattula, Willi L. Wagner, Catherine Disney, Andrew J. Bodey, Thomas Illig, Diana J. Leeming, Morten A. Karsdal, Alexandar Tzankov, Peter Boor, Mark P. Kühnel, Florian P. Länger, Stijn E. Verleden, Hans M. Kvasnicka, Hans H. Kreipe, Axel Haverich, Stephen M. Black, Axel Walch, Paul Tafforeau, Peter D. Lee, Marius M. Hoeper, Tobias Welte, Benjamin Seeliger, Sascha David, Detlef Schuppan, Steven J. Mentzer, Danny D. Jonigk
Publikováno v:
EBioMedicine, Vol 85, Iss , Pp 104296- (2022)
Summary: Background: COVID-19 is characterized by a heterogeneous clinical presentation, ranging from mild symptoms to severe courses of disease. 9–20% of hospitalized patients with severe lung disease die from COVID-19 and a substantial number of
Externí odkaz:
https://doaj.org/article/b4f5f451eaf04dc4b18d8490c6c059a3
Autor:
Nicole de Buhr, Tristan Baumann, Christopher Werlein, Leonie Fingerhut, Rabea Imker, Marita Meurer, Friedrich Götz, Paul Bronzlik, Mark P. Kühnel, Danny D. Jonigk, Johanna Ernst, Andrei Leotescu, Maria M. Gabriel, Hans Worthmann, Ralf Lichtinghagen, Andreas Tiede, Maren von Köckritz-Blickwede, Christine S. Falk, Karin Weissenborn, Ramona Schuppner, Gerrit M. Grosse
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
During the COVID-19 pandemic, vaccination is the most important countermeasure. Pharmacovigilance concerns however emerged with very rare, but potentially disastrous thrombotic complications following vaccination with ChAdOx1. Platelet factor-4 antib
Externí odkaz:
https://doaj.org/article/d9e975e6804a4bf5bf394f03faa7c7cc
Autor:
Ricarda D. Stauss, Gerrit M. Grosse, Lavinia Neubert, Christine S. Falk, Danny Jonigk, Mark P. Kühnel, Maria M. Gabriel, Ramona Schuppner, Ralf Lichtinghagen, Mathias Wilhelmi, Karin Weissenborn, Claudia Schrimpf
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Inflammatory processes are crucial in atherosclerosis and atherothrombosis. This study aimed to identify a cytokine-pattern that is associated with plaque-vulnerability or symptomatic state in comprehensively investigated patients with sympt
Externí odkaz:
https://doaj.org/article/e86abe80c712479098f5bd5ac2b901d5
Autor:
Gerrit M. Grosse, Anselm A. Derda, Ricarda D. Stauss, Lavinia Neubert, Danny D. Jonigk, Mark P. Kühnel, Maria M. Gabriel, Ramona Schuppner, Mathias Wilhelmi, Christian Bär, Johann Bauersachs, Claudia Schrimpf, Thomas Thum, Karin Weissenborn
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background: Specific microRNAs (miRs) have been implicated in the pathophysiology of atherosclerosis and may represent interesting diagnostic and therapeutic targets in carotid stenosis. We hypothesized that the levels of specific circulating miRs ar
Externí odkaz:
https://doaj.org/article/3d5e3aa769e04f7bb7d2aa1544eaca79
Autor:
Melanie Ricke-Hoch, Elisabeth Stelling, Lisa Lasswitz, Antonia P. Gunesch, Martina Kasten, Francisco J. Zapatero-Belinchón, Graham Brogden, Gisa Gerold, Thomas Pietschmann, Virginie Montiel, Jean-Luc Balligand, Federica Facciotti, Emilio Hirsch, Thomas Gausepohl, Husni Elbahesh, Guus F. Rimmelzwaan, Anne Höfer, Mark P. Kühnel, Danny Jonigk, Julian Eigendorf, Uwe Tegtbur, Lena Mink, Michaela Scherr, Thomas Illig, Axel Schambach, Tobias J. Pfeffer, Andres Hilfiker, Axel Haverich, Denise Hilfiker-Kleiner
Publikováno v:
PLoS ONE, Vol 16, Iss 8 (2021)
The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostagland
Externí odkaz:
https://doaj.org/article/2229a694ec8a40d4ab4e27c79d308d6b
Autor:
Theresa A. Kant, Manja Newe, Luise Winter, Maximilian Hoffmann, Susanne Kämmerer, Erik Klapproth, Karolina Künzel, Mark P. Kühnel, Lavinia Neubert, Ali El-Armouche, Stephan R. Künzel
Publikováno v:
Cells, Vol 10, Iss 3, p 617 (2021)
Pulmonary fibrosis is the chronic-progressive replacement of healthy lung tissue by extracellular matrix, leading to the destruction of the alveolar architecture and ultimately death. Due to limited pathophysiological knowledge, causal therapies are
Externí odkaz:
https://doaj.org/article/ce7d379484ec469ba064c6024e626d19
Autor:
Adele Mucci, Jessica Kunkiel, Takuji Suzuki, Sebastian Brennig, Silke Glage, Mark P. Kühnel, Mania Ackermann, Christine Happle, Alexandra Kuhn, Axel Schambach, Bruce C. Trapnell, Gesine Hansen, Thomas Moritz, Nico Lachmann
Publikováno v:
Stem Cell Reports, Vol 7, Iss 2, Pp 292-305 (2016)
Induced pluripotent stem cells (iPSCs) represent an innovative source for the standardized in vitro generation of macrophages (Mφ). We here describe a robust and efficient protocol to obtain mature and functional Mφ from healthy as well as disease-
Externí odkaz:
https://doaj.org/article/a49d4ba7f88649c6adfc2155f149efdb
Autor:
Lea Naasner, Natali Froese, Winfried Hofmann, Paolo Galuppo, Christopher Werlein, Ivanna Shymotiuk, Malgorzata Szaroszyk, Sergej Erschow, Georgios Amanakis, Heike Bähre, Mark P. Kühnel, Danny D. Jonigk, Robert Geffers, Roland Seifert, Melanie Ricke-Hoch, Adam R. Wende, William S. Blaner, E. Dale Abel, Johann Bauersachs, Christian Riehle
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H1352-H1364
Perturbed vitamin-A metabolism is associated with type 2 diabetes and mitochondrial dysfunction that are pathophysiologically linked to the development of diabetic cardiomyopathy (DCM). However, the mechanism, by which vitamin A might regulate mitoch