Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Mark P. Jedrychowski"'
Autor:
Sejeong Shin, Min-Joon Han, Mark P. Jedrychowski, Ziyang Zhang, Kevan M. Shokat, David R. Plas, Noah Dephoure, Sang-Oh Yoon
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112868- (2023)
Summary: Cells maintain and dynamically change their proteomes according to the environment and their needs. Mechanistic target of rapamycin (mTOR) is a key regulator of proteostasis, homeostasis of the proteome. Thus, dysregulation of mTOR leads to
Externí odkaz:
https://doaj.org/article/e32b0783630a4739a55f2de3b20572f4
Autor:
Yang You, Satoshi Muraoka, Mark P. Jedrychowski, Jianqiao Hu, Amanda K. McQuade, Tracy Young‐Pearse, Roshanak Aslebagh, Scott A. Shaffer, Steven P. Gygi, Mathew Blurton‐Jones, Wayne W. Poon, Tsuneya Ikezu
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 1, Pp n/a-n/a (2022)
Abstract In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules and are consequently involved in disease progression. We have investigated the proteomic profiles of EVs that were isolated from four different human
Externí odkaz:
https://doaj.org/article/10a771972cb944f08b28b85ac902d334
Autor:
Satoshi Muraoka, Mark P. Jedrychowski, Harutsugu Tatebe, Annina M. DeLeo, Seiko Ikezu, Takahiko Tokuda, Steven P. Gygi, Robert A. Stern, Tsuneya Ikezu
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Chronic Traumatic Encephalopathy (CTE) is a tauopathy that affects individuals with a history of repetitive mild traumatic brain injury, such as American football players. Initial neuropathologic changes in CTE include perivascular deposition of phos
Externí odkaz:
https://doaj.org/article/18fbd90025b04f478742c53f2688142a
Autor:
Shangyu Hong, Wei Song, Peter-James H. Zushin, Bingyang Liu, Mark P. Jedrychowski, Amir I. Mina, Zhaoming Deng, Dimitrije Cabarkapa, Jessica A. Hall, Colin J. Palmer, Hassan Aliakbarian, John Szpyt, Steven P. Gygi, Ali Tavakkoli, Lydia Lynch, Norbert Perrimon, Alexander S. Banks
Publikováno v:
Molecular Metabolism, Vol 12, Iss , Pp 25-38 (2018)
Objective: The inappropriate release of free fatty acids from obese adipose tissue stores has detrimental effects on metabolism, but key molecular mechanisms controlling FFA release from adipocytes remain undefined. Although obesity promotes systemic
Externí odkaz:
https://doaj.org/article/facf95e5bd7445a89edfd7fa5c8b79f0
Autor:
Ho-Joon Lee, Mark P. Jedrychowski, Arunachalam Vinayagam, Ning Wu, Ng Shyh-Chang, Yanhui Hu, Chua Min-Wen, Jodene K. Moore, John M. Asara, Costas A. Lyssiotis, Norbert Perrimon, Steven P. Gygi, Lewis C. Cantley, Marc W. Kirschner
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 721-736 (2017)
There exist similarities and differences in metabolism and physiology between normal proliferative cells and tumor cells. Once a cell enters the cell cycle, metabolic machinery is engaged to facilitate various processes. The kinetics and regulation o
Externí odkaz:
https://doaj.org/article/c7e10a401bf44c62bebdf01874f9fdbe
Autor:
Naiara Santana-Codina, Sebastian Gableske, Maria Quiles del Rey, Beata Małachowska, Mark P. Jedrychowski, Douglas E. Biancur, Paul J. Schmidt, Mark D. Fleming, Wojciech Fendler, J. Wade Harper, Alec C. Kimmelman, Joseph D. Mancias
Publikováno v:
Haematologica, Vol 104, Iss 7 (2019)
Ncoa4 mediates autophagic degradation of ferritin, the cytosolic iron storage complex, to maintain intracellular iron homeostasis. Recent evidence also supports a role for Ncoa4 in systemic iron homeostasis and erythropoiesis. However, the specific c
Externí odkaz:
https://doaj.org/article/2e99d5fbb5aa4a168f142dcbd5bdfea4
Autor:
Mark P. Jedrychowski, Libin Liu, Collette J. Laflamme, Kalypso Karastergiou, Tova Meshulam, Shi-Ying Ding, Yuanyuan Wu, Mi-Jeong Lee, Steven P. Gygi, Susan K. Fried, Paul F. Pilch
Publikováno v:
Molecular Metabolism, Vol 4, Iss 11, Pp 758-770 (2015)
Objective: Adipocytes are robust protein secretors, most notably of adipokines, hormone-like polypeptides, which act in an endocrine and paracrine fashion to affect numerous physiological processes such as energy balance and insulin sensitivity. To u
Externí odkaz:
https://doaj.org/article/a3dc06a4d9be427492c6dea1f64ccac4
Autor:
Satoshi Muraoka, Mark P. Jedrychowski, Kiran Yanamandra, Seiko Ikezu, Steven P. Gygi, Tsuneya Ikezu
Publikováno v:
Cells, Vol 9, Iss 9, p 1959 (2020)
Pathological hallmarks of Alzheimer’s disease (AD) are deposits of amyloid beta (Aβ) and hyper-phosphorylated tau aggregates in brain plaques. Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in
Externí odkaz:
https://doaj.org/article/4d739c8a28f34d1b8fa851613e4ab023
Autor:
Paul F. Pilch, Ricardo P. Souto, Libin Liu, Mark P. Jedrychowski, Eric A. Berg, Catherine E. Costello, Steven P. Gygi
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 10, Pp 2103-2111 (2007)
It has been known for decades that the adipocyte cell surface is particularly rich in small invaginations we now know to be caveolae. These structures are common to many cell types but are not ubiquitous. They have generated considerable curiosity, a
Externí odkaz:
https://doaj.org/article/83fedbc3a3a4431abae53e721354a479
Autor:
Weihai Liu, Yun Wang, Luiz H. M. Bozi, Patrick D. Fischer, Mark P. Jedrychowski, Haopeng Xiao, Tao Wu, Narek Darabedian, Xiadi He, Evanna L. Mills, Nils Burger, Sanghee Shin, Anita Reddy, Hans-Georg Sprenger, Nhien Tran, Sally Winther, Stephen M. Hinshaw, Jingnan Shen, Hyuk-Soo Seo, Kijun Song, Andrew Z. Xu, Luke Sebastian, Jean J. Zhao, Sirano Dhe-Paganon, Jianwei Che, Steven P. Gygi, Haribabu Arthanari, Edward T. Chouchani
Publikováno v:
Nature. 616:790-797