Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mark P. Gray-Keller"'
Autor:
Alan D. Attie, Ronald M. Krauss, Mark P. Gray-Keller, Alison Brownlie, Makoto Miyazaki, John J. Kastelein, Aldons J. Lusis, Anton F.H. Stalenhoef, Jonathan P. Stoehr, Michael R. Hayden, James M. Ntambi
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 11, Pp 1899-1907 (2002)
Stearoyl-CoA desaturase (SCD) is expressed at high levels in several human tissues and is required for the biosynthesis of oleate (18:1) and palmitoleate (16:1). These monounsaturated fatty acids are the major components of phospholipids, triglycerid
Externí odkaz:
https://doaj.org/article/c9b0aca9a7764e4c88c7c32106c68173
Autor:
Alan D. Attie, Yannick Hamon, Angela R. Brooks-Wilson, Mark P. Gray-Keller, Marcia L.E. MacDonald, Veronique Rigot, Angie Tebon, Lin-Hua Zhang, Jacob D. Mulligan, Roshni R. Singaraja, J.James Bitgood, Mark E. Cook, John J.P. Kastelein, Giovanna Chimini, Michael R. Hayden
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 10, Pp 1610-1617 (2002)
The Wisconsin hypoalpha mutant (WHAM) chicken has a >90% reduction in plasma HDL due to hypercatabolism by the kidney of lipid-poor apoA-I. The WHAM chickens have a recessive white skin phenotype caused by a single-gene mutation that maps to the chic
Externí odkaz:
https://doaj.org/article/cf7ebaa088c742f99091cc5643fa3af9
Autor:
Peter B. Detwiler, Mark P. Gray-Keller
Publikováno v:
Current Opinion in Neurobiology. 6:440-444
Light adaptation in vertebrate photoreceptors is commonly attributed to a feedback mechanism that reduces the amplitude of the receptor potential by speeding the inactivation of the transduction cascade and hastening the recovery process. Recent stud
Autor:
Peter B. Detwiler, Mark P. Gray-Keller
Publikováno v:
Neuron. 13:849-861
Intracellular free Ca (Cai) was measured in functionally intact rod outer segments in darkness and during light responses using the fluorescent Ca indicator Indo-dextran. In darkness, Cai was 554 +/- 25 nM (n = 28) for -85 +/- 2 pA of circulating dar
Autor:
Peter B. Detwiler, Richard S. Johnson, Xinyu Zhao, John W. Crabb, Hiroshi Ohguro, Claudia C. Ruiz, Mark P. Gray-Keller, Wolfgang Baehr, Wojciech A. Gorczyca, Kenneth A. Walsh, Krzysztof Palczewski, Jing Huang, Bharati S. Helekar, Iswari Subbaraya
Publikováno v:
Neuron. 13:395-404
Guanylyl cyclase-activating protein (GCAP) is thought to mediate Ca(2+)-sensitive regulation of guanylyl cyclase (GC), a key event in recovery of the dark state of rod photoreceptors following light exposure. Here, we characterize GCAP from several v
Publikováno v:
Journal of Biological Chemistry. 266:18530-18537
In rod photoreceptor cells, the light response is triggered by an enzymatic cascade that causes cGMP levels to fall: excited rhodopsin (Rho*)----rod G-protein (transducin, Gt)----cGMP-phosphodiesterase (PDE). This results in the closure of plasma mem
Publikováno v:
The Journal of General Physiology
In previous work we have presented evidence for electrogenic Na+/Ca2+ exchange in Limulus ventral photoreceptors (1989. J. Gen. Physiol. 93:473-492). This article assesses the contributions to photoreceptor physiology from Na+/Ca2+ exchange. Four sep
Publikováno v:
Journal of Biological Chemistry. 265:15323-15332
An electropermeabilized preparation of frog retinal rod outer segments (ROS) has been developed to examine the light sensitivity and amplification of visual transduction reactions in a minimally disturbed environment. Electropermeabilized ROS are ind
Autor:
Oliver C. Richards, Mark P. Gray-Keller, Angie T. Oler, Matthew T. Flowers, Kathryn L. Schueler, Alan D. Attie, James M. Ntambi
Publikováno v:
The FASEB Journal. 20
Autor:
Jonathan P. Stoehr, Matthew T. Flowers, Donald S. Stapleton, Mary E. Rabaglia, Brian S. Yandell, Daniel M. Klass, Mark P. Gray-Keller, Susanne M. Clee, Hong Lan, Eric Ton-Keen Mui, Summer M. Raines, Igor V. Boronenkov, Philipp W. Raess, Edward A. Kabara, Oliver C. Richards, Alan D. Attie, Kathryn M. Schueler, Matthew B. Young
Publikováno v:
Nature genetics. 38(6)
We previously mapped the type 2 diabetes mellitus-2 locus (T2dm2), which affects fasting insulin levels, to distal chromosome 19 in a leptin-deficient obese F2 intercross derived from C57BL/6 (B6) and BTBR T+ tf/J (BTBR) mice1. Introgression of a 7-M