Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Mark P. Arends"'
Autor:
Pranay Shah, Ross Hill, Camille Dion, Stephen J. Clark, Abdulkadir Abakir, Jeroen Willems, Mark J. Arends, Juan I. Garaycoechea, Harry G. Leitch, Wolf Reik, Gerry P. Crossan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Mutations in DNA damage response (DDR) factors are associated with human infertility, which affects up to 15% of the population. The DDR is required during germ cell development and meiosis. One pathway implicated in human fertility is DNA t
Externí odkaz:
https://doaj.org/article/9298bed0fab347d4ab08101e4f2d4f6c
Autor:
Mark J Arends, Andrew Robinson, Kishore Gopalakrishnan, Eve Fryer, Betania Mahler-Araujo, Sonali Natu, Elizabeth J Soilleux, Gerald Langman, Kathryn J Kirkwood, EMYR W BENBOW, Caroline A Hughes, Yee Wah Tsang, James Denholm, Benjamin A Schreiber, Florian Jaeckle, Mike N Wicks, Tim S Bracey, James Y H Chan, Lorant Farkas, Raymond F T McMahon, Khun La Win Myint, Ashraf Sanduka, Katharine A Sheppard
Publikováno v:
BMJ Open Gastroenterology, Vol 11, Iss 1 (2024)
Objective Coeliac disease (CD) diagnosis generally depends on histological examination of duodenal biopsies. We present the first study analysing the concordance in examination of duodenal biopsies using digitised whole-slide images (WSIs). We furthe
Externí odkaz:
https://doaj.org/article/f255879a5c044f40853761bffd7965cc
Autor:
Sarah J. Taylor, Robert L. Hollis, Charlie Gourley, C. Simon Herrington, Simon P. Langdon, Mark J. Arends
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundDNA damage repair is frequently dysregulated in high grade serous ovarian cancer (HGSOC), which can lead to changes in chemosensitivity and other phenotypic differences in tumours. RFWD3, a key component of multiple DNA repair and maintenan
Externí odkaz:
https://doaj.org/article/0f37cae0814847a1b8d645d8c736be1e
Autor:
Kim Wong, Federico Abascal, Latasha Ludwig, Heike Aupperle-Lellbach, Julia Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Laura P. Romero, Arnon Gal, Patrick J. Roady, Isabel Pires, Franco Guscetti, John S. Munday, Maria C. Peleteiro, Carlos A. Pinto, Tânia Carvalho, João Cota, Elizabeth C. Du Plessis, Fernando Constantino-Casas, Stephanie Plog, Lars Moe, Simone de Brot, Ingrid Bemelmans, Renée Laufer Amorim, Smitha R. Georgy, Justina Prada, Jorge del Pozo, Marianne Heimann, Louisiane de Carvalho Nunes, Outi Simola, Paolo Pazzi, Johan Steyl, Rodrigo Ubukata, Peter Vajdovich, Simon L. Priestnall, Alejandro Suárez-Bonnet, Franco Roperto, Francesca Millanta, Chiara Palmieri, Ana L. Ortiz, Claudio S. L. Barros, Aldo Gava, Minna E. Söderström, Marie O’Donnell, Robert Klopfleisch, Andrea Manrique-Rincón, Inigo Martincorena, Ingrid Ferreira, Mark J. Arends, Geoffrey A. Wood, David J. Adams, Louise van der Weyden
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-29 (2023)
Abstract Background In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and associated with a poor prognosis. With a high mutation load and large number of altered genes, strategies to delineate key driver events are necessary. Dogs
Externí odkaz:
https://doaj.org/article/7c66e401481649aaa960de808d382f15
Autor:
Albert Burger, Richard A. Baldock, David J. Adams, Shahida Din, Irene Papatheodorou, Michael Glinka, Bill Hill, Derek Houghton, Mehran Sharghi, Michael Wicks, Mark J. Arends
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract Background The Human Cell Atlas resource will deliver single cell transcriptome data spatially organised in terms of gross anatomy, tissue location and with images of cellular histology. This will enable the application of bioinformatics ana
Externí odkaz:
https://doaj.org/article/5036c98cb2794b52894100234eea3c03
Autor:
Samuel B Pattle, Judi O'Shaughnessy, Owen Kantelberg, Olivia M Rifai, Judith Pate, Kristine Nellany, Nadine Hays, Mark J Arends, Mathew H Horrocks, Fergal M Waldron, Jenna M Gregory
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 1, Pp 44-55 (2023)
Abstract Neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS) are traditionally considered strictly neurological disorders. However, clinical presentation is not restricted to
Externí odkaz:
https://doaj.org/article/c5efc50753334660a96f553350f6b2fe
Autor:
Nicole M. Sodir, Luca Pellegrinet, Roderik M. Kortlever, Tania Campos, Yong-Won Kwon, Shinseog Kim, Daniel Garcia, Alessandra Perfetto, Panayiotis Anastasiou, Lamorna Brown Swigart, Mark J. Arends, Trevor D. Littlewood, Gerard I. Evan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Happloinsufficiency of Myc delays onset of cancers in mice. Here, the authors generated a mouse model of reversible cMyc hypomorphism and show that metronomic reduction of c-Myc in adult mice confers protection against cancers without side effects an
Externí odkaz:
https://doaj.org/article/f2edbfdb52b64070a843f6b7ca3e272f
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 8 (2023)
Externí odkaz:
https://doaj.org/article/c375c528246b4f8fbe724d90fe6dc9b4
Autor:
Marcos Yébenes Mayordomo, Sofian Al Shboul, Maria Gómez-Herranz, Asim Azfer, Alison Meynert, Donald Salter, Larry Hayward, Anca Oniscu, James T. Patton, Ted Hupp, Mark J. Arends, Javier Antonio Alfaro
Publikováno v:
BMC Medical Genomics, Vol 15, Iss 1, Pp 1-11 (2022)
Abstract Background Gorham-Stout disease is a rare condition characterized by vascular proliferation and the massive destruction of bone tissue. With less than 400 cases in the literature of Gorham-Stout syndrome, we performed a unique study combinin
Externí odkaz:
https://doaj.org/article/db05fc14fabd4254a1448c19bd87a204
Autor:
Michael N. Wicks, Michael Glinka, Bill Hill, Derek Houghton, Mehran Sharghi, Ingrid Ferreira, David Adams, Shahida Din, Irene Papatheodorou, Kathryn Kirkwood, Michael Cheeseman, Albert Burger, Richard A. Baldock, Mark J. Arends
Publikováno v:
Journal of Pathology Informatics, Vol 14, Iss , Pp 100328- (2023)
Pathologists need to compare histopathological images of normal and diseased tissues between different samples, cases, and species. We have designed an interactive system, termed Comparative Pathology Workbench (CPW), which allows direct and dynamic
Externí odkaz:
https://doaj.org/article/234a0f909ea7415a89096b32fb3d9605