Zobrazeno 1 - 10
of 1 266
pro vyhledávání: '"Mark P Mattson"'
Autor:
Thiruma V Arumugam, Asfa Alli-Shaik, Elisa A Liehn, Sharmelee Selvaraji, Luting Poh, Vismitha Rajeev, Yoonsuk Cho, Yongeun Cho, Jongho Kim, Joonki Kim, Hannah LF Swa, David Tan Zhi Hao, Chutima Rattanasopa, David Yang-Wei Fann, David Castano Mayan, Gavin Yong-Quan Ng, Sang-Ha Baik, Karthik Mallilankaraman, Mathias Gelderblom, Grant R Drummond, Christopher G Sobey, Brian K Kennedy, Roshni R Singaraja, Mark P Mattson, Dong-Gyu Jo, Jayantha Gunaratne
Publikováno v:
eLife, Vol 12 (2023)
Intermittent fasting (IF) has been shown to reduce cardiovascular risk factors in both animals and humans, and can protect the heart against ischemic injury in models of myocardial infarction. However, the underlying molecular mechanisms behind these
Externí odkaz:
https://doaj.org/article/77c3c141082e4538bda530d5762d0666
Autor:
Kelly A Hamilton, Yue Wang, Sophia M Raefsky, Sean Berkowitz, Ryan Spangler, Caitlin N Suire, Simonetta Camandola, Robert H Lipsky, Mark P Mattson
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196223 (2018)
Bhlhe40 is a transcription factor that is highly expressed in the hippocampus; however, its role in neuronal function is not well understood. Here, we used Bhlhe40 null mice on a congenic C57Bl6/J background (Bhlhe40 KO) to investigate the impact of
Externí odkaz:
https://doaj.org/article/29b6816178af4788abed0fca4328ae15
Autor:
Mark A Wilson, Wendy B Iser, Tae Gen Son, Anne Logie, Joao V Cabral-Costa, Mark P Mattson, Simonetta Camandola
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176798 (2017)
Nrf2/skn-1, a transcription factor known to mediate adaptive responses of cells to stress, also regulates energy metabolism in response to changes in nutrient availability. The ability to locate food sources depends upon chemosensation. Here we show
Externí odkaz:
https://doaj.org/article/8f5a50d29a004077b1c1501f783c0f3e
Autor:
Wei Lu, Junhui Sun, Jeong Seon Yoon, Yan Zhang, Lixin Zheng, Elizabeth Murphy, Mark P Mattson, Michael J Lenardo
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147792 (2016)
Necroptosis as a molecular program, rather than simply incidental cell death, was established by elucidating the roles of receptor interacting protein (RIP) kinases 1 and 3, along with their downstream partner, mixed lineage kinase-like domain protei
Externí odkaz:
https://doaj.org/article/ef4be5ebc56d49b79c810e81229c120a
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76721 (2013)
In the process of neurogenesis, neural progenitor cells (NPCs) cease dividing and differentiate into postmitotic neurons that grow dendrites and an axon, become excitable, and establish synapses with other neurons. Mitochondrial biogenesis and aerobi
Externí odkaz:
https://doaj.org/article/5809b6b3544c4f7aa32941b3aecef740
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69030 (2013)
BACKGROUND: Recent findings suggest that NADH-dependent enzymes of the plasma membrane redox system (PMRS) play roles in the maintenance of cell bioenergetics and oxidative state. Neurons and tumor cells exhibit differential vulnerability to oxidativ
Externí odkaz:
https://doaj.org/article/801f549384f04a1e9b30ce0fd95029b0
Autor:
Eitan Okun, Boaz Barak, Ravit Saada-Madar, Sarah M Rothman, Kathleen J Griffioen, Nicholas Roberts, Kamilah Castro, Mohamed R Mughal, Mario A Pita, Alexis M Stranahan, Thiruma V Arumugam, Mark P Mattson
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47522 (2012)
Toll-like receptors (TLRs) play essential roles in innate immunity and increasing evidence indicates that these receptors are expressed in neurons, astrocytes and microglia in the brain where they mediate responses to infection, stress and injury. Ve
Externí odkaz:
https://doaj.org/article/4afce1071bb444bc9788cf6b7f464638
Autor:
Ira Driscoll, Bronwen Martin, Yang An, Stuart Maudsley, Luigi Ferrucci, Mark P Mattson, Susan M Resnick
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35217 (2012)
Brain derived neurotrophic factor (BDNF) seems to be involved in regulation of synaptic plasticity and neurogenesis. BDNF plasma and serum levels have been associated with depression, Alzheimer's disease, and other psychiatric and neurodegenerative d
Externí odkaz:
https://doaj.org/article/882849e1888c40bbb575041b8ec2ec88
Autor:
Yazhou Li, Srinivasulu Chigurupati, Harold W Holloway, Mohamed Mughal, David Tweedie, Daniel A Bruestle, Mark P Mattson, Yun Wang, Brandon K Harvey, Balmiki Ray, Debomoy K Lahiri, Nigel H Greig
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32008 (2012)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by a progressive loss of lower motor neurons in the spinal cord. The incretin hormone, glucagon-like peptide-1 (GLP-1), facilitates insulin signaling, and th
Externí odkaz:
https://doaj.org/article/0ac810526f3b44119ccd3c62030efd0c
Autor:
Rebecca Casaday Potts, Peisu Zhang, Andrea L Wurster, Patricia Precht, Mohamed R Mughal, William H Wood, Yonqing Zhang, Kevin G Becker, Mark P Mattson, Michael J Pazin
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24515 (2011)
CHD5 is frequently deleted in neuroblastoma and is a tumor suppressor gene. However, little is known about the role of CHD5 other than it is homologous to chromatin remodeling ATPases. We found CHD5 mRNA was restricted to the brain; by contrast, most
Externí odkaz:
https://doaj.org/article/b6dc22d1f8ee429592a1873421761779