Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Mark P Hedger"'
Publikováno v:
Asian Journal of Andrology, Vol 17, Iss 5, Pp 756-763 (2015)
Acute epididymitis represents a common medical condition in the urological outpatient clinic. Mostly, epididymitis is caused by bacterial ascent through the urogenital tract, with pathogens originating either from sexually transmitted diseases or uri
Externí odkaz:
https://doaj.org/article/361e72dc8c36469091980e85c3df2e4f
Autor:
David M de Kretser, Jonathan G Bensley, David J Phillips, Bronwyn J Levvey, Greg I Snell, Enjarn Lin, Mark P Hedger, Robyn E O'Hehir
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0140948 (2016)
Lung transplantation exposes the donated lung to a period of anoxia. Re-establishing the circulation after ischemia stimulates inflammation causing organ damage. Since our published data established that activin A is a key pro-inflammatory cytokine,
Externí odkaz:
https://doaj.org/article/f988dbc1ccf0440daa6672de9f448a21
Autor:
Wei Peng, Artem Kepsch, Till O. Kracht, Hiba Hasan, Rukmali Wijayarathna, Eva Wahle, Christiane Pleuger, Sudhanshu Bhushan, Stefan Günther, A. Christine Kauerhof, Ana Planinić, Daniela Fietz, Hans-Christian Schuppe, Małgorzata Wygrecka, Kate L. Loveland, Davor Ježek, Andreas Meinhardt, Mark P. Hedger, Monika Fijak
Publikováno v:
Cellular and Molecular Life Sciences. 79
Experimental autoimmune-orchitis (EAO), a rodent model of chronic testicular inflammation and fibrosis, replicates pathogenic changes seen in some cases of human spermatogenic disturbances. During EAO, increased levels of pro-inflammatory and pro-fib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1210b7391724be69510ed8c4e7ce5214
https://doi.org/10.1007/s00018-022-04632-4
https://doi.org/10.1007/s00018-022-04632-4
Publikováno v:
Reproductive Sciences. 28:2916-2928
Cryptorchidism causes spermatogenic failure and reduced serum androgen levels, as well as testicular oedema and fibrosis, which are hallmarks of inflammation. However, the role of inflammation and the effects of cryptorchidism on Sertoli cell and Ley
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aea70e8c891c42e34f2345c5d9dee8b
https://doi.org/10.1007/s43032-021-00616-0
https://doi.org/10.1007/s43032-021-00616-0
Autor:
Samira Hosseini, Sarah C. Moody, Daniela Fietz, Sivanjah Indumathy, Hans-Christian Schuppe, Mark P. Hedger, Kate L. Loveland
Fetal testis growth involves cell influx and extensive remodeling. Immediately after sex determination in mouse, macrophages enable normal cord formation and removal of inappropriately positioned cells. This study provides new information about macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fd938b887e8e946d33855f497a0bb0
https://doi.org/10.21203/rs.3.rs-1507447/v1
https://doi.org/10.21203/rs.3.rs-1507447/v1
Autor:
Mark A. Febbraio, Darren C. Henstridge, Paul Gregorevic, Jonathan R. Davey, Hongwei Qian, Helen Ludlow, Mark P. Hedger, Martin Whitham, Melinda T. Coughlan, Sean L. McGee, Adam Hagg, Rachel E. Thomson, Emma Estevez, Kevin I. Watt
Publikováno v:
The FASEB Journal. 34:5697-5714
Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating pancreatic β-cell function. The pro-inflammatory factor Activin has been implicated as a positive correlate of severity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0425e1ab158ecfdd0433ae1985430f39
https://doi.org/10.1096/fj.201802059rrr
https://doi.org/10.1096/fj.201802059rrr
Autor:
Sneha Biniwale, Rukmali Wijayarathna, Christiane Pleuger, Sudhanshu Bhushan, Kate L. Loveland, Andreas Meinhardt, Mark P. Hedger
Publikováno v:
Journal of reproductive immunology. 151
The cytokine activin A is expressed throughout testicular development and is a critical regulator of macrophage function, but its effects on the testicular macrophages are not well-defined. Macrophage distribution and gene transcript levels were exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d08bf254981d1e73b29a2fb5835bf8
https://pubmed.ncbi.nlm.nih.gov/35378491
https://pubmed.ncbi.nlm.nih.gov/35378491
Autor:
Kate L Loveland, Andreas Meinhardt, Rosemary Genovese, Mark P. Hedger, Nigel P. Groome, Barry T. Hinton, Rukmali Wijayarathna
Publikováno v:
AndrologyREFERENCES. 10(1)
Background Immunoregulatory genes encoding activin A (Inhba) and B (Inhbb), and indolamine 2,3-dioxygenase-1 (Ido1) are highly expressed in the murine caput epididymidis, which also has a network of intraepithelial mononuclear phagocytes. This enviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25dc48fae2789b6c922120f5a0d00802
https://pubmed.ncbi.nlm.nih.gov/34415685
https://pubmed.ncbi.nlm.nih.gov/34415685
Autor:
A. Christine Kauerhof, Mark P. Hedger, Adrian Pilatz, Hans-Christian Schuppe, Sabine Kliesch, Daniela Fietz, Kate A. Loveland, Sudhanshu Bhushan, Nour Nicolas, Eva Wahle, Nigel P. Groome, Martin Bergmann, Andreas Meinhardt, Monika Fijak
Publikováno v:
Human Reproduction. 34:1536-1550
STUDY QUESTION Does activin A contribute to testicular fibrosis under inflammatory conditions? SUMMARY ANSWER Our results show that activin A and key fibrotic proteins are increased in human testicular biopsies with leukocytic infiltrates and impaire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d994131281fe9a0c34247de084618145
https://doi.org/10.1093/humrep/dez109
https://doi.org/10.1093/humrep/dez109
Autor:
Carsten Rudat, Kate L Loveland, Sudhanshu Bhushan, Rukmali Wijayarathna, Mark P. Hedger, Adrian Pilatz, Ralf Middendorff, Swapnila Pant, Julia Kautz, Britta Klein, Andreas Kispert, Andreas Meinhardt
Publikováno v:
Human Reproduction. 34:1195-1205
STUDY QUESTION Can dexamethasone improve infertility-related cauda epididymidal tissue damage caused by bacterial epididymitis? SUMMARY ANSWER Dexamethasone in addition to anti-microbial treatment effectively reduces long-term deleterious epididymal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac6a102c76a1bf20c5f82335eea058d
https://doi.org/10.1093/humrep/dez073
https://doi.org/10.1093/humrep/dez073