Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Mark P, Ashe"'
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114360- (2024)
Summary: Protein kinase A (PKA) is a conserved kinase crucial for fundamental biological processes linked to growth, development, and metabolism. The PKA catalytic subunit is expressed as multiple isoforms in diverse eukaryotes; however, their contri
Externí odkaz:
https://doaj.org/article/c068c3a39d7b4c42a249e9fb7a220b55
Autor:
Clara A. Solari, María Clara Ortolá Martínez, Juan M. Fernandez, Christian Bates, Gerardo Cueto, María Pía Valacco, Fabián Morales-Polanco, Silvia Moreno, Silvia Rossi, Mark P. Ashe, Paula Portela
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108727- (2024)
Summary: The quiescent state is the prevalent mode of cellular life in most cells. Saccharomyces cerevisiae is a useful model for studying the molecular basis of the cell cycle, quiescence, and aging. Previous studies indicate that heterogeneous ribo
Externí odkaz:
https://doaj.org/article/9edad135970d423c9fcda03143c924e8
Publikováno v:
eLife, Vol 11 (2022)
Regulation of translation is a fundamental facet of the cellular response to rapidly changing external conditions. Specific RNA-binding proteins (RBPs) co-ordinate the translational regulation of distinct mRNA cohorts during stress. To identify RBPs
Externí odkaz:
https://doaj.org/article/bdce106b34294b28b159b3d0baab47c3
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 958 (2022)
Eukaryotic cells have developed a complex circuitry of signalling molecules which monitor changes in their intra- and extracellular environments. One of the most widely studied signalling pathways is the highly conserved cyclic AMP (cAMP)/protein kin
Externí odkaz:
https://doaj.org/article/e47ba015a2874a78b16985bdffbc7296
Autor:
Fabian Morales-Polanco, Christian Bates, Jennifer Lui, Joseph Casson, Clara A. Solari, Mariavittoria Pizzinga, Gabriela Forte, Claire Griffin, Kirsten E.L. Garner, Harriet E. Burt, Hannah L. Dixon, Simon Hubbard, Paula Portela, Mark P. Ashe
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102069- (2021)
Summary: Glycolysis is a fundamental metabolic pathway for glucose catabolism across biology, and glycolytic enzymes are among the most abundant proteins in cells. Their expression at such levels provides a particular challenge. Here we demonstrate t
Externí odkaz:
https://doaj.org/article/277615ee50b9458d93a485e9e993e951
Autor:
Joseph L. Costello, Christopher J. Kershaw, Lydia M. Castelli, David Talavera, William Rowe, Paul F. G. Sims, Mark P. Ashe, Christopher M. Grant, Simon J. Hubbard, Graham D. Pavitt
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-18 (2017)
Abstract Background Translation factors eIF4E and eIF4G form eIF4F, which interacts with the messenger RNA (mRNA) 5′ cap to promote ribosome recruitment and translation initiation. Variations in the association of eIF4F with individual mRNAs likely
Externí odkaz:
https://doaj.org/article/e9827a4beac84ea28a009ec11d03c0fc
Publikováno v:
Microbial Cell, Vol 4, Iss 9, Pp 294-304 (2017)
Candida albicans is a polymorphic yeast where the capacity to switch between yeast and filamentous growth is critical for pathogenicity. Farnesol is a quorum-sensing sesquiterpene alcohol that, via regulation of specific signalling and transcription
Externí odkaz:
https://doaj.org/article/6b2a9f93a7e0418d908b4fee562a480b
Autor:
Chris M. Grant, Mark P. Ashe, Michael G. Nelson, Martin D. Jennings, Christopher J. Kershaw, Christian Bates, Jennifer Lui, Simon J. Hubbard
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Non-membrane-bound compartments such as P-bodies (PBs) and stress granules (SGs) play important roles in the regulation of gene expression following environmental stresses. We have systematically and quantitatively determined the protein and mRNA com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229686f5061365dd6411dba58bcf1287
http://europepmc.org/articles/PMC8782181
http://europepmc.org/articles/PMC8782181
Autor:
Carla E Barraza, Clara A Solari, Irina Marcovich, Christopher Kershaw, Fiorella Galello, Silvia Rossi, Mark P Ashe, Paula Portela
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185416 (2017)
Cellular responses to stress stem from a variety of different mechanisms, including translation arrest and relocation of the translationally repressed mRNAs to ribonucleoprotein particles like stress granules (SGs) and processing bodies (PBs). Here,
Externí odkaz:
https://doaj.org/article/0da646c256a440da968388a2bb703286
Autor:
Jennifer Lui, Lydia M. Castelli, Mariavittoria Pizzinga, Clare E. Simpson, Nathaniel P. Hoyle, Kathryn L. Bailey, Susan G. Campbell, Mark P. Ashe
Publikováno v:
Cell Reports, Vol 9, Iss 3, Pp 944-954 (2014)
The localization of mRNA to defined cytoplasmic sites in eukaryotic cells not only allows localized protein production but also determines the fate of mRNAs. For instance, translationally repressed mRNAs localize to P-bodies and stress granules where
Externí odkaz:
https://doaj.org/article/22609927aa394d33915147f9530bce5f