Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Mark Opdam"'
Autor:
Yuwei Wang, Gwen M. H. E. Dackus, Efraim H. Rosenberg, Sten Cornelissen, Leonora W. de Boo, Annegien Broeks, Wim Brugman, Terry W. S. Chan, Paul J. van Diest, Michael Hauptmann, Natalie D. ter Hoeve, Olga I. Isaeva, Vincent M. T. de Jong, Katarzyna Jóźwiak, Roelof J. C. Kluin, Marleen Kok, Esther Koop, Petra M. Nederlof, Mark Opdam, Philip C. Schouten, Sabine Siesling, Charlaine van Steenis, Adri C. Voogd, Willem Vreuls, Roberto F. Salgado, Sabine C. Linn, Marjanka K. Schmidt
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Due to the abundant usage of chemotherapy in young triple-negative breast cancer (TNBC) patients, the unbiased prognostic value of BRCA1-related biomarkers in this population remains unclear. In addition, whether BRCA1-related bio
Externí odkaz:
https://doaj.org/article/ddff242b9c864f39864f3885aee7bad4
Autor:
Stefan Prekovic, Theofilos Chalkiadakis, Merel Roest, Daniel Roden, Catrin Lutz, Karianne Schuurman, Mark Opdam, Liesbeth Hoekman, Nina Abbott, Tanja Tesselaar, Maliha Wajahat, Amy R Dwyer, Isabel Mayayo‐Peralta, Gabriela Gomez, Maarten Altelaar, Roderick Beijersbergen, Balázs Győrffy, Leonie Young, Sabine Linn, Jos Jonkers, Wayne Tilley, Theresa Hickey, Damir Vareslija, Alexander Swarbrick, Wilbert Zwart
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp n/a-n/a (2023)
Abstract Glucocorticoid receptor (GR) is a transcription factor that plays a crucial role in cancer biology. In this study, we utilized an in silico‐designed GR activity signature to demonstrate that GR relates to the proliferative capacity of nume
Externí odkaz:
https://doaj.org/article/7f89e9b972df425581429cdb0b5d1a09
Deep learning-based breast cancer grading and survival analysis on whole-slide histopathology images
Autor:
Suzanne C. Wetstein, Vincent M. T. de Jong, Nikolas Stathonikos, Mark Opdam, Gwen M. H. E. Dackus, Josien P. W. Pluim, Paul J. van Diest, Mitko Veta
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Breast cancer tumor grade is strongly associated with patient survival. In current clinical practice, pathologists assign tumor grade after visual analysis of tissue specimens. However, different studies show significant inter-observer varia
Externí odkaz:
https://doaj.org/article/b59fee3b27c34ccfb9661b4cad529743
Autor:
Sandra Tavares, Nalan Liv, Milena Pasolli, Mark Opdam, Max A.K. Rätze, Manuel Saornil, Lilian M. Sluimer, Rutger C.C. Hengeveld, Robert van Es, Erik van Werkhoven, Harmjan Vos, Holger Rehmann, Boudewijn M.T. Burgering, Hendrika M. Oosterkamp, Susanne M.A. Lens, Judith Klumperman, Sabine C. Linn, Patrick W.B. Derksen
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110584- (2022)
Summary: Elevated expression of non-receptor tyrosine kinase FER is an independent prognosticator that correlates with poor survival of high-grade and basal/triple-negative breast cancer (TNBC) patients. Here, we show that high FER levels are also as
Externí odkaz:
https://doaj.org/article/9434a26e702a448687ec52764f334902
Autor:
Esther H. Lips, Anne Benard-Slagter, Mark Opdam, Caroline E. Scheerman, Jelle Wesseling, Frans B. L. Hogervorst, Sabine C. Linn, Suvi Savola, Petra M. Nederlof
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)
Abstract Background We previously showed that BRCA-like profiles can be used to preselect individuals with the highest risk of carrying BRCA mutations but could also indicate which patients would benefit from double-strand break inducing chemotherapy
Externí odkaz:
https://doaj.org/article/80a0d3ee97954d7c860270878592b294
Autor:
Marcelo Sobral-Leite, Izhar Salomon, Mark Opdam, Dinja T. Kruger, Karin J. Beelen, Vincent van der Noort, Ronald L. P. van Vlierberghe, Erik J. Blok, Daniele Giardiello, Joyce Sanders, Koen Van de Vijver, Hugo M. Horlings, Peter J. K. Kuppen, Sabine C. Linn, Marjanka K. Schmidt, Marleen Kok
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-12 (2019)
Abstract Introduction The presence of tumor-infiltrating lymphocytes (TILs) is correlated with good prognosis and outcome after (immuno)therapy in triple-negative and HER2-positive breast cancer. However, the role of TILs in luminal breast cancer is
Externí odkaz:
https://doaj.org/article/5959f536479546c2a4aaf6e54c131c05
Autor:
Sjoerd Klarenbeek, Chris W. Doornebal, Sjors M. Kas, Nicola Bonzanni, Jinhyuk Bhin, Tanya M. Braumuller, Ingrid van der Heijden, Mark Opdam, Philip C. Schouten, Kelly Kersten, Roebi de Bruijn, Daniel Zingg, Julia Yemelyanenko, Lodewyk F.A. Wessels, Karin E. de Visser, Jos Jonkers
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Effective treatment of invasive lobular carcinoma (ILC) of the breast is hampered by late detection, invasive growth, distant metastasis, and poor response to chemotherapy. Phosphoinositide 3-kinase (PI3K) signaling, one of the major druggable oncoge
Externí odkaz:
https://doaj.org/article/54b9a172c50d4990871cfc2608c09c9c
Autor:
Karin Beelen, Mark Opdam, Tesa Severson, Rutger Koornstra, Andrew Vincent, Jelle Wesseling, Joyce Sanders, Jan Vermorken, Paul van Diest, Sabine Linn
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background Controversy exists for the use of Ki67 protein expression as a predictive marker to select patients who do or do not derive benefit from adjuvant endocrine therapy. Whether other proliferation markers, like Cyclin D1, and mitotic
Externí odkaz:
https://doaj.org/article/c558154a46ac40b6b7bc562fdd869e71
Autor:
Gregory Verghese, Mengyuan Li, Fangfang Liu, Amit Lohan, Nikhil Cherian Kurian, Swati Meena, Patrycja Gazinska, Aekta Shah, Aasiyah Oozeer, Terry Chan, Mark Opdam, Sabine Linn, Cheryl Gillett, Elena Alberts, Thomas Hardiman, Samantha Jones, Selvam Thavaraj, J Louise Jones, Roberto Salgado, Sarah E Pinder, Swapnil Rane, Amit Sethi, Anita Grigoriadis
Publikováno v:
The Journal of Pathology.
Autor:
Vincent M.T. de Jong, Yuwei Wang, Natalie D. ter Hoeve, Mark Opdam, Nikolas Stathonikos, Katarzyna Jóźwiak, Michael Hauptmann, Sten Cornelissen, Willem Vreuls, Efraim H. Rosenberg, Esther A. Koop, Zsuzsanna Varga, Carolien H.M. van Deurzen, Antien L. Mooyaart, Alicia Córdoba, Emma J. Groen, Joost Bart, Stefan M. Willems, Vasiliki Zolota, Jelle Wesseling, Anna Sapino, Ewa Chmielik, Ales Ryska, Annegien Broeks, Adri C. Voogd, Sherene Loi, Stefan Michiels, Gabe S. Sonke, Elsken van der Wall, Sabine Siesling, Paul J. van Diest, Marjanka K. Schmidt, Marleen Kok, Gwen M.H.E. Dackus, Roberto Salgado, Sabine C. Linn
Publikováno v:
Journal of Clinical Oncology, 40(21), 2361-2374. American Society of Clinical Oncology
Journal of clinical oncology, 40(21), 2361-2374. American Society of Clinical Oncology
Journal of Clinical Oncology, 40(21), 2361-+. AMER SOC CLINICAL ONCOLOGY
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 40(21), 2361-2374. American Society of Clinical Oncology
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 40(21), 2361-2375. AMER SOC CLINICAL ONCOLOGY
Journal of clinical oncology, 40(21), 2361-2374. American Society of Clinical Oncology
Journal of Clinical Oncology, 40(21), 2361-+. AMER SOC CLINICAL ONCOLOGY
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 40(21), 2361-2374. American Society of Clinical Oncology
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 40(21), 2361-2375. AMER SOC CLINICAL ONCOLOGY
PURPOSE Triple-negative breast cancer (TNBC) is considered aggressive, and therefore, virtually all young patients with TNBC receive (neo)adjuvant chemotherapy. Increased stromal tumor-infiltrating lymphocytes (sTILs) have been associated with a favo