Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Mark O. Wielpütz"'
Autor:
Friedemann G. Ringwald, Lena Wucherpfennig, Niclas Hagen, Jonas Mücke, Sebastian Kaletta, Monika Eichinger, Mirjam Stahl, Simon M. F. Triphan, Patricia Leutz-Schmidt, Sonja Gestewitz, Simon Y. Graeber, Hans-Ulrich Kauczor, Abdulsattar Alrajab, Jens-Peter Schenk, Olaf Sommerburg, Marcus A. Mall, Petra Knaup, Mark O. Wielpütz, Urs Eisenmann
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionSegmentation of lung structures in medical imaging is crucial for the application of automated post-processing steps on lung diseases like cystic fibrosis (CF). Recently, machine learning methods, particularly neural networks, have demons
Externí odkaz:
https://doaj.org/article/c357ed5510a04bf597f2f82ce4f81936
Autor:
Felix Doellinger, Grzegorz Bauman, Jobst Roehmel, Mirjam Stahl, Helena Posch, Ingo G. Steffen, Orso Pusterla, Oliver Bieri, Mark O. Wielpütz, Marcus A. Mall
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundPrevious studies showed that contrast-enhanced (CE) morpho-functional magnetic resonance imaging (MRI) detects abnormalities in lung morphology and perfusion in patients with cystic fibrosis (CF). Novel matrix pencil decomposition MRI (MP-M
Externí odkaz:
https://doaj.org/article/d30e0f3e95134ae39a69e52e8fdb80d0
Autor:
Simon M. F. Triphan, Marilisa Konietzke, Jürgen Biederer, Monika Eichinger, Claus F. Vogelmeier, Rudolf A. Jörres, Hans-Ulrich Kauczor, Claus P. Heußel, Bertram J. Jobst, Mark O. Wielpütz, on behalf of the COSYCONET study group
Publikováno v:
Frontiers in Medicine, Vol 10 (2024)
IntroductionDue to hypoxic vasoconstriction, perfusion is interesting in the lungs. Magnetic Resonance Imaging (MRI) perfusion imaging based on Dynamic Contrast Enhancement (DCE) has been demonstrated in patients with Chronic Obstructive Pulmonary Di
Externí odkaz:
https://doaj.org/article/a1d397260ae64480a0156ee5ab1d261d
Autor:
Jonas Albers, Willi L. Wagner, Mascha O. Fiedler, Anne Rothermel, Felix Wünnemann, Francesca Di Lillo, Diego Dreossi, Nicola Sodini, Elisa Baratella, Marco Confalonieri, Fulvia Arfelli, Armin Kalenka, Joachim Lotz, Jürgen Biederer, Mark O. Wielpütz, Hans-Ulrich Kauczor, Frauke Alves, Giuliana Tromba, Christian Dullin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Absorption-based clinical computed tomography (CT) is the current imaging method of choice in the diagnosis of lung diseases. Many pulmonary diseases are affecting microscopic structures of the lung, such as terminal bronchi, alveolar spaces
Externí odkaz:
https://doaj.org/article/5be2ca35a6d24d6c9ef72be79938eb48
Autor:
Sabine Dettmer, Oliver Weinheimer, Annette Sauer-Heilborn, Oliver Lammers, Mark O. Wielpütz, Jan Fuge, Tobias Welte, Frank Wacker, Felix C. Ringshausen
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: The availability of highly effective triple cystic fibrosis transmembrane conductance regulator (CFTR) modulator combination therapy with elexacaftor–tezacaftor–ivacaftor (ETI) has improved pulmonary outcomes and quality of life of
Externí odkaz:
https://doaj.org/article/f1eff76b32b944939457d4d815eba6f7
Autor:
Lena Wucherpfennig, Felix Wuennemann, Monika Eichinger, Angelika Seitz, Ingo Baumann, Mirjam Stahl, Simon Y. Graeber, Shengkai Zhao, Jaehi Chung, Jens-Peter Schenk, Abdulsattar Alrajab, Hans-Ulrich Kauczor, Marcus A. Mall, Olaf Sommerburg, Mark O. Wielpütz
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Chronic rhinosinusitis (CRS) usually presents with nasal congestion, rhinorrhea and anosmia impacts quality of life in cystic fibrosis (CF). Especially mucopyoceles pathognomonic for CRS in CF may cause complications such as spread of i
Externí odkaz:
https://doaj.org/article/9457291a67fc47c8a7f559c9d492eb6d
Autor:
Patricia Leutz-Schmidt, Daiva-Elzbieta Optazaite, Olaf Sommerburg, Monika Eichinger, Sabine Wege, Eva Steinke, Simon Y. Graeber, Michael U. Puderbach, Jens-Peter Schenk, Abdulsattar Alrajab, Simon M.F. Triphan, Hans-Ulrich Kauczor, Mirjam Stahl, Marcus A. Mall, Mark O. Wielpütz
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Background Bronchial artery dilatation (BAD) is associated with haemoptysis in advanced cystic fibrosis (CF) lung disease. Our aim was to evaluate BAD onset and its association with disease severity by magnetic resonance imaging (MRI). Methods 188 CF
Externí odkaz:
https://doaj.org/article/88967b4379074ce3884f0c3d5830b010
Autor:
Oliver Weinheimer, Philip Konietzke, Willi L. Wagner, Dorothea Weber, Beverly Newman, Craig J. Galbán, Hans-Ulrich Kauczor, Marcus A. Mall, Terry E. Robinson, Mark O. Wielpütz
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
ObjectivesQuantitative computed tomography (QCT) offers some promising markers to quantify cystic fibrosis (CF)-lung disease. Air trapping may precede irreversible bronchiectasis; therefore, the temporal interdependencies of functional and structural
Externí odkaz:
https://doaj.org/article/449af3d86b7140669ed3c77f9323ce8f
Autor:
Marilisa Konietzke, Simon M. F. Triphan, Monika Eichinger, Sebastian Bossert, Hartmut Heller, Sabine Wege, Ralf Eberhardt, Michael U. Puderbach, Hans-Ulrich Kauczor, Gudula Heußel, Claus P. Heußel, Frank Risse, Mark O. Wielpütz
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) allows the assessment of pulmonary perfusion, which may play a key role in the development of muco-obstructive lung disease. One problem with quantifying pulmonary perfusion is
Externí odkaz:
https://doaj.org/article/1ca8b4993189489d94245dcd273b73f9
Autor:
Julia Duerr, Dominik H. W. Leitz, Magdalena Szczygiel, Dmytro Dvornikov, Simon G. Fraumann, Clemens Kreutz, Piotr K. Zadora, Ayça Seyhan Agircan, Philip Konietzke, Theresa A. Engelmann, Jan Hegermann, Surafel Mulugeta, Hiroshi Kawabe, Lars Knudsen, Matthias Ochs, Daniela Rotin, Thomas Muley, Michael Kreuter, Felix J. F. Herth, Mark O. Wielpütz, Michael F. Beers, Ursula Klingmüller, Marcus A. Mall
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognosis. Here, the authors show that deficiency of the E3 ubiqutin-protein ligase Nedd4-2 in airway epithelial cells causes IPF-like disease in adult mice. This model may aid st
Externí odkaz:
https://doaj.org/article/ae55c88d44b14c0496555b2c7a52b8da