Výsledky vyhledávání - "Mark O Palmier"

An examination of the proteolytic activity for bovine pregnancy-associated glycoproteins 2 and 12

Autor: Bhanu Prakash V.L. Telugu, Steven R. Van Doren, Jonathan A. Green, Mark O. Palmier

Publikováno v: Biological Chemistry. 391:259-270

The pregnancy-associated glycoproteins (PAGs) represent a complex group of putative aspartic peptidases expressed exclusively in the placentas of species in the Artiodactyla order. The ruminant PAGs segregate into two classes: the ‘ancient’ and �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76bec4a40447992c8d2d9c702a9158f
https://doi.org/10.1515/bc.2010.016

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Inactivation of N-TIMP-1 by N-terminal acetylation when expressed in bacteria

Autor: Steven R. Van Doren, Guanghua Gao, Mark O. Palmier, Beverly B. DaGue, Keith Brew, Harinath Bahudhanapati, Shuo Wei

Publikováno v: Biopolymers. 89:960-968

The high-affinity binding of tissue inhibitors of metalloproteinases (TIMPs) to matrix metalloproteinases (MMPs) is essential for regulation of the turnover of the extracellular matrix during development, wound healing, and progression of inflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98e9adbcd19158b75dd5225b9476cf7
https://doi.org/10.1002/bip.21043

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Rapid determination of enzyme kinetics from fluorescence: Overcoming the inner filter effect

Autor: Mark O. Palmier, Steven R. Van Doren

Publikováno v: Analytical Biochemistry. 371:43-51

Fluorescence change is convenient for monitoring enzyme kinetics. Unfortunately, it loses linearity as the absorbance of the fluorescent substrate increases with concentration. When the sum of absorbance at excitation and emission wavelengths exceeds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0db73037ee802b7d0f157c1987da98f
https://doi.org/10.1016/j.ab.2007.07.008

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Solubilized elastin substrate for continuous fluorimetric assay of kinetics of elastases

Autor: Yan G. Fulcher, Mark O. Palmier, Steven R. Van Doren

Publikováno v: Analytical Biochemistry. 408:172-174

Elastolysis is central to progression of emphysema and aortic aneurysms. Characterization of steady-state enzyme kinetics of elastolysis is fettered by the insolubility of mature elastin and the polydispersity of solubilized elastin. We prepared a fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9589c7ca24cde99508a7d206e9561758
https://doi.org/10.1016/j.ab.2010.09.001

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Heparin-tissue Factor Pathway Inhibitor Complexes: Anticoagulant and Pharmacokinetic Properties

Autor: Mark O. Palmier, Tze-Chein Wun

Publikováno v: Clinical and Applied Thrombosis/Hemostasis. 4:179-188

Exogenous addition of full-length tissue factor pathway inhibitor (FL-TFPI) to plasma caused a greater pro longation of prothrombin time (PT) than activated partial thromboplastin time (APTT). In contrast, heparin elicited a greater prolongation of A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12c564a61ec9ea8732b5140a253d3013
https://doi.org/10.1177/107602969800400307

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Peptide Phage Display for Discovery of Novel Biomarkers for Imaging and Therapy of Cell Subpopulations in Ovarian Cancer

Autor: Susan L. Deutscher, Mette Soendergaard, Mark O Palmier, Jessica R. Newton-Northup

Publikováno v: Journal of Molecular Biomarkers & Diagnosis.

Ovarian cancer is a very aggressive disease that is mostly asymptomatic at early onset. Approximately 85% of patients are diagnosed at late-stage disease, which greatly compromises full recovery. Standard detection methods include measurement of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecbf59ae23fb06f7312ffbc974343441
https://doi.org/10.4172/2155-9929.s2-004

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Refold and Characterization of Recombinant Tissue Factor Pathway Inhibitor Expressed in Escherichia coli

Autor: Judy A Diaz-Collier, Mark O Palmier, Kuniko K Kretzmer, Bruce F Bishop, Rodney G Combs, Mark G Obukowicz, Ronald B Frazier, Gary S Bild, William D Joy, Steven R Hill, Kevin L Duffin, Mark E Gustafson, Kurt D Junger, Roy W Grabner, Gerald R Galluppi, Tze-Chein Wun

Publikováno v: Thrombosis and Haemostasis. 71:339-346

SummaryHuman tissue factor pathway inhibitor (TFPI) was expressed in E. coli as a non-glycosylated protein with an additional alanine attached to the aminoterminus of the wild type molecule. High-level expression was obtained with pMON6875, a plasmid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d487d2cf3fa01b602b11748ce7d00869
https://doi.org/10.1055/s-0038-1642440

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Clearance of Recombinant Tissue Factor Pathway Inhibitor (TFPI) in Rabbits

Autor: Tze-Chein Wun, Mark O. Palmier, Margaret K Baldwin, Alan G. E. Wilson, Celeste M Reisch, Lori J. Hall

Publikováno v: Thrombosis and Haemostasis. 68:033-036

SummaryThe pharmacokinetics of recombinant tissue factor pathway inhibitor (TFPI) after an intravenous bolus injection was studied in rabbits. Clearance of TFPI was followed by measurement of the radioactivity of the 125I-labelled compound in the who

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f26df3d72af8b1ca89acbc1f847ef205
https://doi.org/10.1055/s-0038-1656313

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