Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Mark O Collins"'
Autor:
Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O Collins, Seth G N Grant, Yasunori Hayashi, Toru Takumi
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002006 (2024)
Proteome analyses of the postsynaptic density (PSD), a proteinaceous specialization beneath the postsynaptic membrane of excitatory synapses, have identified several thousands of proteins. While proteins with predictable functions have been well stud
Externí odkaz:
https://doaj.org/article/eb1ee277ee014075a0fa347c43877bf9
Autor:
Mona Nazemi, Bian Yanes, Montserrat Llanses Martinez, Heather J Walker, Khoa Pham, Mark O Collins, Frederic Bard, Elena Rainero
Publikováno v:
PLoS Biology, Vol 22, Iss 1, p e3002406 (2024)
Breast tumours are embedded in a collagen I-rich extracellular matrix (ECM) network, where nutrients are scarce due to limited blood flow and elevated tumour growth. Metabolic adaptation is required for cancer cells to endure these conditions. Here,
Externí odkaz:
https://doaj.org/article/73bd8338597b4be8864562ecae43c95e
Autor:
Ankur V Patel, Robert D Turner, Aline Rifflet, Adelina E Acosta-Martin, Andrew Nichols, Milena M Awad, Dena Lyras, Ivo Gomperts Boneca, Marshall Bern, Mark O Collins, Stéphane Mesnage
Publikováno v:
eLife, Vol 10 (2021)
Many software solutions are available for proteomics and glycomics studies, but none are ideal for the structural analysis of peptidoglycan (PG), the essential and major component of bacterial cell envelopes. It icomprises glycan chains and peptide s
Externí odkaz:
https://doaj.org/article/dc8df51d605e44f7b13fa1ec6b79a43e
Autor:
Mathieu Brochet, Mark O Collins, Terry K Smith, Eloise Thompson, Sarah Sebastian, Katrin Volkmann, Frank Schwach, Lia Chappell, Ana Rita Gomes, Matthew Berriman, Julian C Rayner, David A Baker, Jyoti Choudhary, Oliver Billker
Publikováno v:
PLoS Biology, Vol 12, Iss 3, p e1001806 (2014)
Many critical events in the Plasmodium life cycle rely on the controlled release of Ca²⁺ from intracellular stores to activate stage-specific Ca²⁺-dependent protein kinases. Using the motility of Plasmodium berghei ookinetes as a signalling par
Externí odkaz:
https://doaj.org/article/2e9ff0eabae14cb39898e2aeb02503e0
Autor:
Alex Bayés, Mark O Collins, Mike D R Croning, Louie N van de Lagemaat, Jyoti S Choudhary, Seth G N Grant
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46683 (2012)
Direct comparison of protein components from human and mouse excitatory synapses is important for determining the suitability of mice as models of human brain disease and to understand the evolution of the mammalian brain. The postsynaptic density is
Externí odkaz:
https://doaj.org/article/342cf640ca6b4fbd9b5c1b3bc2ed6d66
Autor:
Siyu Wang, Louise Fairall, Trong Khoa Pham, Timothy J Ragan, Dipti Vashi, Mark O Collins, Cyril Dominguez, John W R Schwabe
Publikováno v:
Nucleic Acids Research.
Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails. In addition to the d
Autor:
Amélie Bonaud, Laetitia Gargowitsch, Simon M. Gilbert, Elanchezhian Rajan, Pablo Canales-Herrerias, Daniel Stockholm, Nabila F. Rahman, Mark O. Collins, Hakan Taskiran, Danika L. Hill, Andres Alloatti, Nagham Alouche, Stéphanie Balor, Vanessa Soldan, Daniel Gillet, Julien Barbier, Françoise Bachelerie, Kenneth G. C. Smith, Julia Jellusova, Pierre Bruhns, Sebastian Amigorena, Karl Balabanian, Michelle A. Linterman, Andrew A. Peden, Marion Espéli
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (2), pp.e2213056120. ⟨10.1073/pnas.2213056120⟩
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (2), pp.e2213056120. ⟨10.1073/pnas.2213056120⟩
Despite the essential role of plasma cells in health and disease, the cellular mechanisms controlling their survival and secretory capacity are still poorly understood. Here, we identified the soluble N-ethylmaleimide-sensitive factor attachment prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f62eb6890c17956c3a9822f5a059b5a
https://hal.science/hal-04064289v1/document
https://hal.science/hal-04064289v1/document
Autor:
Bret Sanders, Daniel D’Andrea, Mark O. Collins, Elliott Rees, Tom G. J. Steward, Ying Zhu, Gareth Chapman, Sophie E. Legge, Antonio F. Pardiñas, Adrian J. Harwood, William P. Gray, Michael C. O’Donovan, Michael J. Owen, Adam C. Errington, Derek J. Blake, Daniel J. Whitcomb, Andrew J. Pocklington, Eunju Shin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Nature Communications
Sanders, B, D’Andrea, D, Collins, M O, Rees, E, Steward, T G J, Zhu, Y, Chapman, G, Legge, S E, Pardiñas, A F, Harwood, A J, Gray, W P, O’Donovan, M C, Owen, M J, Errington, A C, Blake, D J, Whitcomb, D J, Pocklington, A J & Shin, E 2022, ' Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants ', Nature Communications, vol. 13, no. 1, 27 . https://doi.org/10.1038/s41467-021-27601-0
Nature Communications
Sanders, B, D’Andrea, D, Collins, M O, Rees, E, Steward, T G J, Zhu, Y, Chapman, G, Legge, S E, Pardiñas, A F, Harwood, A J, Gray, W P, O’Donovan, M C, Owen, M J, Errington, A C, Blake, D J, Whitcomb, D J, Pocklington, A J & Shin, E 2022, ' Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants ', Nature Communications, vol. 13, no. 1, 27 . https://doi.org/10.1038/s41467-021-27601-0
Coordinated programs of gene expression drive brain development. It is unclear which transcriptional programs, in which cell-types, are affected in neuropsychiatric disorders such as schizophrenia. Here we integrate human genetics with transcriptomic
Publikováno v:
Molecular Omics
Lysine specific demethylase 1 (LSD1) regulates gene expression as part of the CoREST complex, along with co-repressor of REST (CoREST) and histone deacetylase 1 (HDAC1). CoREST is recruited to specific genomic loci by core components and numerous tra
Damage to our genome causes acute senescence in mammalian cells, which undergo growth arrest and release a secretome that elicits cell cycle arrest in bystander cells through the senescence-associated secretory phenotype (SASP). Thus, acute senescenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e38e43d9addabe984249da4f09edbac
https://doi.org/10.1101/2022.10.05.510870
https://doi.org/10.1101/2022.10.05.510870