Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Mark Novotny"'
Autor:
Ely Cheikh Boussaty, Neil Tedeschi, Mark Novotny, Yuzuru Ninoyu, Eric Du, Clara Draf, Yun Zhang, Uri Manor, Richard H. Scheuermann, Rick Friedman
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Age-related hearing loss (ARHL) is the most common cause of hearing loss and one of the most prevalent conditions affecting the elderly worldwide. Despite evidence from our lab and others about its polygenic nature, little is known about the specific
Externí odkaz:
https://doaj.org/article/fe06f769e4d24d9f9b0b1d86f5294812
Autor:
Rebecca D. Hodge, Jeremy A. Miller, Mark Novotny, Brian E. Kalmbach, Jonathan T. Ting, Trygve E. Bakken, Brian D. Aevermann, Eliza R. Barkan, Madeline L. Berkowitz-Cerasano, Charles Cobbs, Francisco Diez-Fuertes, Song-Lin Ding, Jamison McCorrison, Nicholas J. Schork, Soraya I. Shehata, Kimberly A. Smith, Susan M. Sunkin, Danny N. Tran, Pratap Venepally, Anna Marie Yanny, Frank J. Steemers, John W. Phillips, Amy Bernard, Christof Koch, Roger S. Lasken, Richard H. Scheuermann, Ed S. Lein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Little is known about von Economo neurons, which have been described in a subset of mammals and appear to be selectively lost in several human neurological diseases. Here, authors reveal the gene expression profile of these cells and show that they a
Externí odkaz:
https://doaj.org/article/78763ec182d74a1e969da1bbe56703f2
Autor:
Brian D. Aevermann, Casey P. Shannon, Mark Novotny, Rym Ben-Othman, Bing Cai, Yun Zhang, Jamie C. Ye, Michael S. Kobor, Nicole Gladish, Amy Huei-Yi Lee, Travis M. Blimkie, Robert E. Hancock, Alba Llibre, Darragh Duffy, Wayne C. Koff, Manish Sadarangani, Scott J. Tebbutt, Tobias R. Kollmann, Richard H. Scheuermann
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Vaccination to prevent infectious disease is one of the most successful public health interventions ever developed. And yet, variability in individual vaccine effectiveness suggests that a better mechanistic understanding of vaccine-induced immune re
Externí odkaz:
https://doaj.org/article/01893990f9944581a1f3cc78d5f56382
Autor:
Rym Ben-Othman, Bing Cai, Aaron C. Liu, Natallia Varankovich, Daniel He, Travis M. Blimkie, Amy H. Lee, Erin E. Gill, Mark Novotny, Brian Aevermann, Sibyl Drissler, Casey P. Shannon, Sarah McCann, Kim Marty, Gordean Bjornson, Rachel D. Edgar, David Tse Shen Lin, Nicole Gladish, Julia Maclsaac, Nelly Amenyogbe, Queenie Chan, Alba Llibre, Joyce Collin, Elise Landais, Khoa Le, Samantha M. Reiss, Wayne C. Koff, Colin Havenar-Daughton, Manraj Heran, Bippan Sangha, David Walt, Mel Krajden, Shane Crotty, Devin Sok, Bryan Briney, Dennis R. Burton, Darragh Duffy, Leonard J. Foster, William W. Mohn, Michael S. Kobor, Scott J. Tebbutt, Ryan R. Brinkman, Richard H. Scheuermann, Robert E. W. Hancock, Tobias R. Kollmann, Manish Sadarangani
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Conventional vaccine design has been based on trial-and-error approaches, which have been generally successful. However, there have been some major failures in vaccine development and we still do not have highly effective licensed vaccines for tuberc
Externí odkaz:
https://doaj.org/article/161a4130886644838de4892cc5710d1d
Autor:
Trygve Bakken, Lindsay Cowell, Brian D. Aevermann, Mark Novotny, Rebecca Hodge, Jeremy A. Miller, Alexandra Lee, Ivan Chang, Jamison McCorrison, Bali Pulendran, Yu Qian, Nicholas J. Schork, Roger S. Lasken, Ed S. Lein, Richard H. Scheuermann
Publikováno v:
BMC Bioinformatics, Vol 18, Iss S17, Pp 7-16 (2017)
Abstract Background A fundamental characteristic of multicellular organisms is the specialization of functional cell types through the process of differentiation. These specialized cell types not only characterize the normal functioning of different
Externí odkaz:
https://doaj.org/article/a305d64a8be2415ebaf4f86a83546ebe
Autor:
David M. Brown, Alison M. Hixon, Lauren M. Oldfield, Yun Zhang, Mark Novotny, Wei Wang, Suman R. Das, Reed S. Shabman, Kenneth L. Tyler, Richard H. Scheuermann
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Enterovirus D68 (EV-D68) has historically been associated with respiratory illnesses. However, in the summers of 2014 and 2016, EV-D68 outbreaks coincided with a spike in polio-like acute flaccid myelitis/paralysis (AFM/AFP) cases. This rais
Externí odkaz:
https://doaj.org/article/0c234f64f2d24fabae6975211feab844
Autor:
Benjamin Lacar, Sara B. Linker, Baptiste N. Jaeger, Suguna Rani Krishnaswami, Jerika J. Barron, Martijn J. E. Kelder, Sarah L. Parylak, Apuã C. M. Paquola, Pratap Venepally, Mark Novotny, Carolyn O'Connor, Conor Fitzpatrick, Jennifer A. Erwin, Jonathan Y. Hsu, David Husband, Michael J. McConnell, Roger Lasken, Fred H. Gage
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The molecular dynamics associated with neuronal activation patterns in vivo are unclear. Lacar et al. perform single-nuclei RNA-sequencing of hippocampal neurons from mice exposed to a novel environment, and identify large-scale transcriptome changes
Externí odkaz:
https://doaj.org/article/945908deb567490ab967344cc571a206
Autor:
Rajshekhar R. Giraddi, Chi-Yeh Chung, Richard E. Heinz, Ozlen Balcioglu, Mark Novotny, Christy L. Trejo, Christopher Dravis, Berhane M. Hagos, Elnaz Mirzaei Mehrabad, Luo Wei Rodewald, Jae Y. Hwang, Cheng Fan, Roger Lasken, Katherine E. Varley, Charles M. Perou, Geoffrey M. Wahl, Benjamin T. Spike
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)
Summary: The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We ad
Externí odkaz:
https://doaj.org/article/38eeb434d83440d7b7cd474042626a72
Autor:
Benjamin Lacar, Sara B. Linker, Baptiste N. Jaeger, Suguna Rani Krishnaswami, Jerika J. Barron, Martijn J. E. Kelder, Sarah L Parylak, Apuã C. M. Paquola, Pratap Venepally, Mark Novotny, Carolyn O’Connor, Conor Fitzpatrick, Jennifer A. Erwin, Jonathan Y. Hsu, David Husband, Michael J. McConnell, Roger Lasken, Fred H. Gage
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 7: Article number: 11022 (2016); Published 19 April 2016; Updated 17 March 2017 An incorrect version of Supplementary Data 1, in which normalized counts were analysed instead of raw counts, resulting in a smaller number of diffe
Externí odkaz:
https://doaj.org/article/f31904b35b4948faadb5285253683701
Autor:
Benjamin Lacar, Sara B. Linker, Baptiste N. Jaeger, Suguna Rani Krishnaswami, Jerika J. Barron, Martijn J. E. Kelder, Sarah L. Parylak, Apuã C. M. Paquola, Pratap Venepally, Mark Novotny, Carolyn O’Connor, Conor Fitzpatrick, Jennifer A. Erwin, Jonathan Y. Hsu, David Husband, Michael J. McConnell, Roger Lasken, Fred H. Gage
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications 7: Article number:11022 (2016); Published 19 April 2016; Updated 14 June 2016 In the original version of this Article, the middle names or initials of the authors Suguna Rani Krishnaswami, Jerika J. Barron, Martijn J.E. Kelder,
Externí odkaz:
https://doaj.org/article/5684b7501cfc453aae6e218622c3bb80