Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Mark Naples"'
Autor:
Jennifer Taher, Christopher L. Baker, Carmelle Cuizon, Hassan Masoudpour, Rianna Zhang, Sarah Farr, Mark Naples, Celine Bourdon, Zdenka Pausova, Khosrow Adeli
Publikováno v:
Molecular Metabolism, Vol 3, Iss 9, Pp 823-833 (2014)
Background/objectives: Fasting dyslipidemia is commonly observed in insulin resistant states and mechanistically linked to hepatic overproduction of very low density lipoprotein (VLDL). Recently, the incretin hormone glucagon-like peptide-1 (GLP-1) h
Externí odkaz:
https://doaj.org/article/c285b753e9aa4bbfac2aee97f60e7fdd
Autor:
Stephen L. Pinkosky, Sergey Filippov, Rai Ajit K. Srivastava, Jeffrey C. Hanselman, Cheryl D. Bradshaw, Timothy R. Hurley, Clay T. Cramer, Mark A. Spahr, Ashley F. Brant, Jacob L. Houghton, Chris Baker, Mark Naples, Khosrow Adeli, Roger S. Newton
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 1, Pp 134-151 (2013)
ETC-1002 (8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) is a novel investigational drug being developed for the treatment of dyslipidemia and other cardio-metabolic risk factors. The hypolipidemic, anti-atherosclerotic, anti-obesity, and gluc
Externí odkaz:
https://doaj.org/article/cec4f54dcb2f41e99d4df80fe4b930fe
Autor:
Mark Naples
Publikováno v:
PhotonicsViews. 20:57-59
Autor:
Jing Zhang, Kevin Chien, Mark Naples, Dominic S. Ng, Dinushan Nesan, Graham F. Maguire, Amir Bashiri, Carolyn L. Cummins, Ian Sue-Chue-Lam, Khosrow Adeli, Ghazaleh Tavallaee, Lilia Magomedova
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1861:594-605
Non-alcoholic steatohepatitis (NASH), is the form of non-alcoholic fatty liver disease posing risk to progress into serious long term complications. Human and pre-clinical models implicate cellular cholesterol dysregulation playing important role in
Autor:
Benjamin A. Alman, Henry Ma, Sarah Farr, Khosrow Adeli, Shabana Amanda Ali, Heather Whetstone, Mushriq Al-Jazrawe, Mark Naples, Raymond Poon
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Objective With no effective therapies to attenuate cartilage degeneration in osteoarthritis (OA), the result is pain and disability. Activation of hedgehog (HH) signaling causes changes related to the progression of OA, with higher levels of Gli-medi
Autor:
Jahangir Iqbal, Mahmood Hussain, Khosrow Adeli, Mark Naples, Sarah Farr, Christopher Baker, Jennifer Taher
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35:1092-1100
Objective— Intestinal overproduction of atherogenic chylomicron particles postprandially is an important component of diabetic dyslipidemia in insulin-resistant states. In addition to enhancing insulin secretion, peripheral glucagon-like peptide-1
Autor:
Carmelle Cuizon, Mark Naples, Rianna Zhang, Khosrow Adeli, Hassan Masoudpour, Celine Bourdon, Sarah Farr, Christopher Baker, Zdenka Pausova, Jennifer Taher
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 3, Iss 9, Pp 823-833 (2014)
Molecular Metabolism, Vol 3, Iss 9, Pp 823-833 (2014)
Background/objectives Fasting dyslipidemia is commonly observed in insulin resistant states and mechanistically linked to hepatic overproduction of very low density lipoprotein (VLDL). Recently, the incretin hormone glucagon-like peptide-1 (GLP-1) ha
Autor:
Christopher Baker, Mark Naples, Xuedong Tong, Kezhong Zhang, Khosrow Adeli, Qiaozhu Su, Patricia Christian, Miklós Sántha
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 306:E1264-E1273
Emerging evidence demonstrates a close interplay between disturbances in mitochondrial function and ER homeostasis in the development of the metabolic syndrome. The present investigation sought to advance our understanding of the communication betwee
Autor:
Robert S. Kiss, Cheng-I J. Ma, Mark Naples, Yanqin Qi, Jing Zhang, Allan D. Sniderman, Rui Hao Leo Wang, Khosrow Adeli, Christopher A. Baker
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33:2481-2490
Objective— The hypothesis that cholesterol that enters the cell within low-density lipoprotein (LDL) particles rapidly equilibrates with the regulatory pool of intracellular cholesterol and maintains cholesterol homeostasis by reducing cholesterol
Autor:
Mark A. Spahr, Jeffrey C. Hanselman, Roger S. Newton, Rai Ajit K. Srivastava, Mark Naples, Clay T. Cramer, Stephen L. Pinkosky, Timothy R. Hurley, Khosrow Adeli, Jacob L. Houghton, Sergey Filippov, Cheryl D. Bradshaw, Ashley F. Brant, Christopher Baker
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 1, Pp 134-151 (2013)
ETC-1002 (8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) is a novel investigational drug being developed for the treatment of dyslipidemia and other cardio-metabolic risk factors. The hypolipidemic, anti-atherosclerotic, anti-obesity, and gluc