Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mark Namchuk"'
Autor:
E. Richard Gold, Sarah E. Ali-Khan, Liz Allen, Lluis Ballell, Manoel Barral-Netto, David Carr, Damien Chalaud, Simon Chaplin, Matthew S. Clancy, Patricia Clarke, Robert Cook-Deegan, A. P. Dinsmore, Megan Doerr, Lisa Federer, Steven A. Hill, Neil Jacobs, Antoine Jean, Osmat Azzam Jefferson, Chonnettia Jones, Linda J. Kahl, Thomas M. Kariuki, Sophie N. Kassel, Robert Kiley, Elizabeth Robboy Kittrie, Bianca Kramer, Wen Hwa Lee, Emily MacDonald, Lara M. Mangravite, Elizabeth Marincola, Daniel Mietchen, Jennifer C. Molloy, Mark Namchuk, Brian A. Nosek, Sébastien Paquet, Claude Pirmez, Annabel Seyller, Malcolm Skingle, S. Nicole Spadotto, Sophie Staniszewska, Mike Thelwall
Publikováno v:
Gates Open Research, Vol 3 (2019)
Serious concerns about the way research is organized collectively are increasingly being raised. They include the escalating costs of research and lower research productivity, low public trust in researchers to report the truth, lack of diversity, po
Externí odkaz:
https://doaj.org/article/e8de9a5c77f144a2ac156a12c415c78c
Autor:
Dean J. Welsch, Saurabh Saha, Caroline M. Emery, Mark Namchuk, Gary DeCrescenzo, Anna Groover, Kathryn Meshaw, Ramin Samadani, Michael J. Wick, Paul Shapiro, Matthew Fitzgibbon, Gabriel Martinez-Botella, David A. Sorrell, Diane M. Boucher, Michael Hale, Jeffrey J. Roix, Alex M. Aronov, Russell R. Hoover, William Markland, Brinley F. Furey, Ursula A. Germann
Supplementary materials and methods and supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2691c8ce88b24315d90208e7f0fa7411
https://doi.org/10.1158/1535-7163.22508691.v1
https://doi.org/10.1158/1535-7163.22508691.v1
Autor:
Dean J. Welsch, Saurabh Saha, Caroline M. Emery, Mark Namchuk, Gary DeCrescenzo, Anna Groover, Kathryn Meshaw, Ramin Samadani, Michael J. Wick, Paul Shapiro, Matthew Fitzgibbon, Gabriel Martinez-Botella, David A. Sorrell, Diane M. Boucher, Michael Hale, Jeffrey J. Roix, Alex M. Aronov, Russell R. Hoover, William Markland, Brinley F. Furey, Ursula A. Germann
In SW48 colorectal cells engineered with KRAS alleles, response to paclitaxel was unaltered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37056904b019df912ca990e86321623e
https://doi.org/10.1158/1535-7163.22508697.v1
https://doi.org/10.1158/1535-7163.22508697.v1
Publikováno v:
Journal of the American Chemical Society. 122:1270-1277
A series of monosubstituted deoxy and deoxyfluoro 2,4-dinitrophenyl (DNP) β-d-glycopyranosides was synthesized and used to probe the mechanism of spontaneous β-glycoside hydrolysis. Their relative rates of hydrolysis followed the order 2-deoxy > 4-
Publikováno v:
Iminosugars as Glycosidase Inhibitors: Nojirimycin and Beyond
Autor:
Stephen G. Withers, Mark Namchuk
Publikováno v:
Biochemistry. 34:16194-16202
The role of noncovalent interactions in the catalytic mechanism of the Agrobacterium faecalis beta-glucosidase was investigated by steady-state and pre-steady state kinetic analysis of the hydrolysis of a series of monosubstituted aryl glycosides, in
Autor:
Ruedi Aebersold, R. Antony J. Warren, Mark Namchuk, Stephen G. Withers, Donald E. Trimbur, John C. Gebler
Publikováno v:
Biochemistry. 34:14547-14553
The beta-glucosidase from Agrobacterium sp. catalyzes the hydrolysis of beta-glucosides via a covalent alpha-D-glucopyranosyl-enzyme intermediate involving Glu358. Hydrolysis of 2,4-dinitrophenyl beta-D-glucopyranoside by the low activity Glu358Asp m
Publikováno v:
ChemInform. 31
Autor:
Mahesh H. Goghari, Tom C. Covey, Edward J. Bures, Bori Shushan, Ruedi Aebersold, Mark Namchuk
Publikováno v:
Protein Science. 1:494-503
We report the design, chemical synthesis, and structural and functional characterization of a novel reagent for protein sequence analysis by the Edman degradation, yielding amino acid derivatives rapidly detectable at high sensitivity by ion-evaporat
Autor:
Woods, Wannamaker, Robert, Davies, Mark, Namchuk, John, Pollard, Pamella, Ford, George, Ku, Caroline, Decker, Paul, Charifson, Peter, Weber, Ursula A, Germann, Keisuke, Kuida, John C R, Randle
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 321(2)
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765) is an orally absorbed prodrug of (S)-3-({1-[(S)-1-((S)-2-{[1-(4-amino-3-ch