Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mark N. Warden"'
Autor:
Susan Searles Nielsen, Mark N. Warden, Markku Sallmén, Markku Sainio, Sanni Uuksulainen, Harvey Checkoway, Christer Hublin, Brad A. Racette
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 4, Iss , Pp 100092- (2021)
Introduction: Epidemiologic and toxicology studies suggest that exposure to various solvents, especially chlorinated hydrocarbon solvents, might increase Parkinson disease (PD) risk. Methods: In a population-based case-control study in Finland, we ex
Externí odkaz:
https://doaj.org/article/f51f1414335042d3bd86f32cd874177c
Autor:
Mark N. Warden, Susan Searles Nielsen, Joel S. Perlmutter, Stephen M. Moerlein, Jason Lenox-Krug, Susan R. Criswell, Wendy W. Dlamini, Lianne Sheppard, Harvey Checkoway, Brad A. Racette
Publikováno v:
Toxicol Sci
The relationships between the neurotoxicant manganese (Mn), dopaminergic pathology, and parkinsonism remain unclear. Therefore, we used [11C](N-methyl)benperidol (NMB) positron emission tomography to investigate the associations between Mn exposure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e5583388c7630ba464ba6415ca5d47
https://doi.org/10.1093/toxsci/kfab045
https://doi.org/10.1093/toxsci/kfab045
Autor:
Roman Garnett, Brad A. Racette, Susan Searles Nielsen, Alejandra Camacho-Soto, Mark N. Warden
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256592 (2021)
PLoS ONE
PLoS ONE
Identifying people with Parkinson disease during the prodromal period, including via algorithms in administrative claims data, is an important research and clinical priority. We sought to improve upon an existing penalized logistic regression model,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c2ceb8242b30a9871833ab1ffb513d
https://doaj.org/article/4f17074530b341eaa642d598bcba33fe
https://doaj.org/article/4f17074530b341eaa642d598bcba33fe
Autor:
Joel S. Perlmutter, Susan Searles Nielsen, Jason Lenox-Krug, Lianne Sheppard, Stephen M. Moerlein, Susan R. Criswell, Brad A. Racette, Mark N. Warden, Harvey Checkoway
Publikováno v:
J Occup Environ Med
OBJECTIVE: To understand the neurotoxic effects of manganese (Mn) exposure on monoaminergic function, utilizing [(11)C]dihydrotetrabenazine (DTBZ) positron emission tomography (PET) to measure vesicular monoamine transporter 2 (VMAT2). METHODS: Basal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d9c1f063fadc8705eec1e241906faa
https://europepmc.org/articles/PMC7786890/
https://europepmc.org/articles/PMC7786890/
Autor:
Susan Searles Nielsen, Susan R. Criswell, Lianne Sheppard, John L Huang, Brad A. Racette, Harvey Checkoway, Mark N. Warden, Stephen M. Moerlein, Noah S. Seixas, Hubert P. Flores, Joel S. Perlmutter
Publikováno v:
NeuroToxicology. 64:43-49
Occupational manganese (Mn) exposure is associated with the development of parkinsonism; however, the mechanism of neurotoxicity is unknown. Brain positron emission tomography (PET) imaging provides a non-invasive method of assessing dopamineric neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e3dbfe45abe7b8bc3ce40cf0b5b8a9
https://doi.org/10.1016/j.neuro.2017.07.004
https://doi.org/10.1016/j.neuro.2017.07.004
Autor:
Brad A. Racette, Harvey Checkoway, Mark N. Warden, Susan Searles Nielsen, Susan R. Criswell, Jason Lenox-Krug, Sophia Racette, Lianne Sheppard, Hubert P. Flores
Objective T1-weighted brain magnetic resonance imaging (MRI) of the basal ganglia provides a noninvasive measure of manganese (Mn) exposure, and may also represent a biomarker for clinical neurotoxicity. Methods We acquired T1-weighted MRI scans in 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980945e6366b3f21e90625008b747bc6
https://europepmc.org/articles/PMC7098806/
https://europepmc.org/articles/PMC7098806/
Autor:
Susan Searles Nielsen, Brad A. Racette, Anat Gross, Amber Salter, Anna N. Miller, Mark N. Warden, Alejandra Camacho-Soto
Publikováno v:
Neurology. 94(23)
ObjectiveTo examine the association between fractures and Parkinson disease (PD) during the 5-year prodromal phase as compared to controls.MethodsWe performed a population-based case–control study of Medicare beneficiaries in the United States from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a8146e34ca0a17791b0b44739c9a3e
https://pubmed.ncbi.nlm.nih.gov/32345729
https://pubmed.ncbi.nlm.nih.gov/32345729
Autor:
Susan R. Criswell, Brad A. Racette, Noah S. Seixas, Harvey Checkoway, Lianne Sheppard, Mark N. Warden, Susan Searles Nielsen
Publikováno v:
Neurology. 88:344-351
Objective:To determine whether the parkinsonian phenotype prevalent in welders is progressive, and whether progression is related to degree of exposure to manganese (Mn)-containing welding fume.Methods:This was a trade union–based longitudinal coho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfee67b076205989afa117aa245a3f3
https://doi.org/10.1212/wnl.0000000000003533
https://doi.org/10.1212/wnl.0000000000003533
Autor:
Markku Sainio, Christer Hublin, Susan Searles Nielsen, Markku Sallmén, Brad A. Racette, Mark N. Warden, Sanni Uuksulainen, Harvey Checkoway
Publikováno v:
Clinical Parkinsonism & Related Disorders
Clinical Parkinsonism & Related Disorders, Vol 4, Iss, Pp 100092-(2021)
Clinical Parkinsonism & Related Disorders, Vol 4, Iss, Pp 100092-(2021)
Highlights • Finnish register-based case-control Parkinson disease (PD) studies are feasible. • Some occupations with potential for exposure to solvents are associated with PD. • Chlorinated hydrocarbon solvents in particular might increase PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bf789b5a07d1c31ade9da0c7cf8a1d
https://doi.org/10.1016/j.prdoa.2021.100092
https://doi.org/10.1016/j.prdoa.2021.100092
Autor:
Joel S. Perlmutter, Brad A. Racette, Lianne Sheppard, Mark N. Warden, Susan Searles Nielsen, Stephen M. Moerlein, Jason Lenox-Krug, Harvey Checkoway, Susan R. Criswell
Publikováno v:
Neurology. 91(11)
ObjectiveTo investigate the associations between manganese (Mn) exposure, D2 dopamine receptors (D2Rs), and parkinsonism using [11C](N-methyl)benperidol (NMB) PET.MethodsWe used NMB PET to evaluate 50 workers with a range of Mn exposure: 22 Mn-expose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d32be650c16b4d11f7a425ea3d2b605
https://pubmed.ncbi.nlm.nih.gov/30097475
https://pubmed.ncbi.nlm.nih.gov/30097475