Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Mark N. Prichard"'
Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population
Autor:
Lisa N. Akhtar, Christopher D. Bowen, Daniel W. Renner, Utsav Pandey, Ashley N. Della Fera, David W. Kimberlin, Mark N. Prichard, Richard J. Whitley, Matthew D. Weitzman, Moriah L. Szpara
Publikováno v:
mSphere, Vol 4, Iss 1 (2019)
ABSTRACT More than 14,000 neonates are infected with herpes simplex virus (HSV) annually. Approximately half display manifestations limited to the skin, eyes, or mouth (SEM disease). The rest develop invasive infections that spread to the central ner
Externí odkaz:
https://doaj.org/article/aa2c3b7fa3974724b3e58319699cd762
Autor:
Mark N. Prichard, Earl R. Kern
Publikováno v:
Viruses, Vol 2, Iss 9, Pp 1968-1983 (2010)
The search for effective therapies for orthopoxvirus infections has identified diverse classes of molecules with antiviral activity. Pyrimidine analogs, such as 5-iodo-2'-deoxyuridine (idoxuridine, IDU) were among the first compounds identified with
Externí odkaz:
https://doaj.org/article/86fbba630102455aac62c024bbeb15df
Autor:
Elke Lipka, Aaron M. Chadderdon, Cheryl C. Harteg, Matthew K. Doherty, Eric S. Simon, John M. Domagala, Dawn M. Reyna, Kim M. Hutchings, Xinmin Gan, Andrew D. White, Caroll B. Hartline, Emma A. Harden, Kathy A. Keith, Mark N. Prichard, Scott H. James, Rhonda D. Cardin, David I. Bernstein, Jacqueline F. Spencer, Ann E. Tollefson, William S. M. Wold, Karoly Toth
Publikováno v:
Molecular pharmaceutics. 20(1)
DNA viruses are responsible for many diseases in humans. Current treatments are often limited by toxicity, as in the case of cidofovir (CDV, Vistide), a compound used against cytomegalovirus (CMV) and adenovirus (AdV) infections. CDV is a polar molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b560c5d392d9bace6b395fe7f5302d
https://pubmed.ncbi.nlm.nih.gov/36484496
https://pubmed.ncbi.nlm.nih.gov/36484496
Publikováno v:
RSC Medicinal Chemistry. 12:804-808
The substantial impact of acyclic nucleoside phosphonates (ANPs) on human medicine encourages the synthesis of new ANP analogues with a potentially differentiated antiviral spectrum. Herein, we demonstrate the functionalization of the 2-position of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e296fdc6dc037099d0480c16b132e46f
https://doi.org/10.1039/d1md00086a
https://doi.org/10.1039/d1md00086a
Autor:
Stepan G. Pilyo, Victor V. Zhirnov, V. S. Brovarets, Emma A. Harden, Mark N. Prichard, Nataliya V. Velychko, Mykhailo Y. Brusnakov, Scott H. James, Oleksandr V. Golovchenko, E. R. Abdurakhmanova
Publikováno v:
Medicinal Chemistry Research. 29:1669-1675
A series of derivatives of 5-hydroxyalkylamino-1,3-oxazoles were synthesized. Among these derivatives, 5 compounds have been evaluated for their activities against a normal laboratory human cytomegalovirus (HCMV) strain, AD169, in human foreskin fibr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f19c1a6b5430475f98d965c7a9a6f0b6
https://doi.org/10.1007/s00044-020-02593-6
https://doi.org/10.1007/s00044-020-02593-6
Autor:
R. N. Solomyannyi, Oleg P. Mitiukhin, Volodymyr Brovarets, Scott H. James, Mark N. Prichard, Victor V. Zhirnov, Carol Hartline
Publikováno v:
Current Chemistry Letters, Vol 9, Iss 2, Pp 89-96 (2019)
Five imidazo[1,2-c]pyrimidine and pyrimido[1,6-a]pyrimidine derivatives were designed, synthesized and evaluated for their antiproliferative activity and cytotoxicity. Primary bioassays in vitro showed that two of five synthesized compounds, 6-benzyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbd831af5976a8daaf38a6271aaf9df
https://doi.org/10.5267/j.ccl.2019.9.001
https://doi.org/10.5267/j.ccl.2019.9.001
Autor:
Andrea J. Parsons, Sabrina I. Ophir, Thomas J. Gardner, Jailene Casado Paredes, Kathryn R. Stein, Steven M. Kwasny, Steven C. Cardinale, Matthew Torhan, Mark N. Prichard, Scott H. James, Kristina E. Atanasoff, Narendran G-Dayanandan, Terry L. Bowlin, Timothy J. Opperman, Domenico Tortorella
Publikováno v:
Antiviral Research. 209:105474
Human cytomegalovirus (CMV) is a ubiquitous β-herpesvirus that establishes latent asymptomatic infections in healthy individuals but can cause serious infections in immunocompromised people, resulting in increased risk of morbidity and mortality. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33efc4316f8c6a98fd65200109a1564e
https://doi.org/10.1016/j.antiviral.2022.105474
https://doi.org/10.1016/j.antiviral.2022.105474
Autor:
Emma A. Harden, Volodymyr Brovarets, Caroll B. Hartline, Victor V. Zhirnov, Maryna V. Kachaeva, Stepan G. Pilyo, Mark N. Prichard
Publikováno v:
Medicinal Chemistry Research. 28:1205-1211
Ten 5-functionalized derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile were synthesized and their antiviral activities against the human cytomegalovirus (HCMV) were evaluated in vitro. Bioassays showed that seven compounds exhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed324439dd31eba917e40de3eecb45d3
https://doi.org/10.1007/s00044-019-02365-x
https://doi.org/10.1007/s00044-019-02365-x
Autor:
Allan Jensen, R. Mark L. Buller, Mark N. Prichard, June Ann D'Angelo, Sarah L. George, Henriette Schjønning Nielsen, Johan Lantto, Scott Parker, Donald F. Smee
Publikováno v:
Antiviral research. 195
Orthopoxviruses such as variola and monkeypox viruses continue to threaten the human population. Monkeypox virus is endemic in central and western Africa and outbreaks have reached as far as the U.S. Although variola virus, the etiologic agent of sma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44d7ffad40773b9a47db4f0c26c8f9a
https://pubmed.ncbi.nlm.nih.gov/34530009
https://pubmed.ncbi.nlm.nih.gov/34530009
Publikováno v:
RSC Med Chem
The substantial impact of acyclic nucleoside phosphonates (ANPs) on human medicine encourages the synthesis of new ANP analogues with a potentially differentiated antiviral spectrum. Herein, we demonstrate the functionalization of the 2-position of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3a002515ac3a11850985f151983f452
https://pubmed.ncbi.nlm.nih.gov/34124679
https://pubmed.ncbi.nlm.nih.gov/34124679