Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Mark N. Adams"'
Autor:
Habib Sadeghirad, James Monkman, Chin Wee Tan, Ning Liu, Joseph Yunis, Meg L. Donovan, Afshin Moradi, Niyati Jhaveri, Chris Perry, Mark N. Adams, Ken O’Byrne, Majid E. Warkiani, Rahul Ladwa, Brett G.M. Hughes, Arutha Kulasinghe
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) generally has a poor prognosis for patients with limited treatment options. While incorporating immune checkpoint inhibitors (ICIs) has now become the standard
Externí odkaz:
https://doaj.org/article/f1dddeab14594adbaeaca19710053a73
Autor:
Tabassum Khair Barbhuiya, Sam Beard, Esha T. Shah, Steven Mason, Emma Bolderson, Ken O’Byrne, Luke W. Guddat, Derek J. Richard, Mark N. Adams, Neha S. Gandhi
Publikováno v:
ACS Omega, Vol 9, Iss 7, Pp 8362-8373 (2024)
Externí odkaz:
https://doaj.org/article/980348c0606c4f249eee8b785d64abc2
Autor:
Maddison Rose, Joshua T. Burgess, Chee Man Cheong, Mark N. Adams, Parastoo Shahrouzi, Kenneth J. O’Byrne, Derek J. Richard, Emma Bolderson
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundTriple-negative breast cancer (TNBC) is a sub-classification of breast carcinomas, which leads to poor survival outcomes for patients. TNBCs do not possess the hormone receptors that are frequently targeted as a therapeutic in other cancer
Externí odkaz:
https://doaj.org/article/730fd40bf05e413cbdb093bdcca0200a
Autor:
Thais Sobanski, Amila Suraweera, Joshua T. Burgess, Iain Richard, Chee Man Cheong, Keyur Dave, Maddison Rose, Mark N. Adams, Kenneth J. O’Byrne, Derek J. Richard, Emma Bolderson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Glucose metabolism and DNA repair are fundamental cellular processes frequently dysregulated in cancer. In this study, we define a direct role for the glycolytic Aldolase A (ALDOA) protein in DNA double-strand break (DSB) repair. ALDOA is a
Externí odkaz:
https://doaj.org/article/a81c8e487a144595879ce2d50a37a29b
Autor:
Zachariah P. Schuurs, Alexander P. Martyn, Carl P. Soltau, Sam Beard, Esha T. Shah, Mark N. Adams, Laura V. Croft, Kenneth J. O’Byrne, Derek J. Richard, Neha S. Gandhi
Publikováno v:
Biology, Vol 12, Iss 11, p 1405 (2023)
Human single-stranded DNA binding protein 1 (hSSB1) is critical to preserving genome stability, interacting with single-stranded DNA (ssDNA) through an oligonucleotide/oligosaccharide binding-fold. The depletion of hSSB1 in cell-line models leads to
Externí odkaz:
https://doaj.org/article/487676582ec54863a72b53d556791520
Autor:
Habib Sadeghirad, Ning Liu, James Monkman, Ning Ma, Bassem Ben Cheikh, Niyati Jhaveri, Chin Wee Tan, Majid Ebrahimi Warkiani, Mark N. Adams, Quan Nguyen, Rahul Ladwa, Oliver Braubach, Ken O’Byrne, Melissa Davis, Brett G. M. Hughes, Arutha Kulasinghe
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mucosal head and neck squamous cell carcinoma (HNSCC) are the seventh most common cancer, with approximately 50% of patients living beyond 5 years. Immune checkpoint inhibitors (ICIs) have shown promising results in patients with recurrent or metasta
Externí odkaz:
https://doaj.org/article/deb6e95791cc45ce81a3059cd2e13bb7
Autor:
Katrina Kildey, Neha S. Gandhi, Katherine B. Sahin, Esha T. Shah, Eric Boittier, Pascal H. G. Duijf, Christopher Molloy, Joshua T. Burgess, Sam Beard, Emma Bolderson, Amila Suraweera, Derek J. Richard, Kenneth J. O’Byrne, Mark N. Adams
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Kildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA
Externí odkaz:
https://doaj.org/article/1fca8dd3265e4aecb2ae8d295b050bfa
Autor:
Amila Suraweera, Neha S. Gandhi, Sam Beard, Joshua T. Burgess, Laura V. Croft, Emma Bolderson, Ali Naqi, Nicholas W. Ashton, Mark N. Adams, Kienan I. Savage, Shu-Dong Zhang, Kenneth J. O’Byrne, Derek J. Richard
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Amila Suraweera et al. use a range of biochemical and in vitro cellular assays to examine the role of the COMMD4 in DNA repair. Their results suggest that COMMD4 interacts with the histone H2A-H2B during repair of double-stranded DNA breaks, thereby
Externí odkaz:
https://doaj.org/article/d6ec5b410c7346699b96af09c2c4016b
Autor:
Arutha Kulasinghe, James Monkman, Esha T. Shah, Nicholas Matigian, Mark N. Adams, Ken O’Byrne
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has few effective treatment options due to its lack of targetable hormone receptors. Whilst the degree of tumour infiltrating lymphocytes (TILs) has been shown to ass
Externí odkaz:
https://doaj.org/article/9c01c659e52f479baee118d7889c2297
Autor:
Nathalie Bock, Farzaneh Forouz, Luke Hipwood, Julien Clegg, Penny Jeffery, Madeline Gough, Tirsa van Wyngaard, Christopher Pyke, Mark N. Adams, Laura J. Bray, Laura Croft, Erik W. Thompson, Thomas Kryza, Christoph Meinert
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 261 (2023)
3D organoid model technologies have led to the development of innovative tools for cancer precision medicine. Yet, the gold standard culture system (Matrigel®) lacks the ability for extensive biophysical manipulation needed to model various cancer m
Externí odkaz:
https://doaj.org/article/5a542fd7c7cc4e5e896ca4a5ca644885