Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Mark N Wu"'
Publikováno v:
eLife, Vol 6 (2017)
The ellipsoid body (EB) in the Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ring (R) neuron axons and mediates multifaceted sensory integration and motor coordination functions. However, what regula
Externí odkaz:
https://doaj.org/article/b384610d767a44a4b0a67bf884da1a2e
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
BackgroundSleep problem is a common complication of Alzheimer’s disease (AD). Extensive preclinical studies have been performed to investigate the AD pathology. However, the pathophysiological consequence of AD complicated by sleep problem remains
Externí odkaz:
https://doaj.org/article/15286e73ac2d4a20aa0495e998a1b803
Autor:
Adam P Spira, Christopher Yager, Jason Brandt, Gwenn S Smith, Yun Zhou, Anil Mathur, Anil Kumar, James R Brašić, Dean F Wong, Mark N Wu
Publikováno v:
SAGE Open Medicine, Vol 2 (2014)
Background/aims: Although disturbed sleep is associated with cognitive deficits, the association between sleep disturbance and Alzheimer’s disease pathology is unclear. In this pilot study, we examined the extent to which sleep duration, sleep qual
Externí odkaz:
https://doaj.org/article/3c37c59f3cda4fabb428ba0d66e26366
Autor:
Xiaoyu Li, Yang Yang, Xiaobing Bai, Xiaotong Wang, Houqi Tan, Yanbo Chen, Yan Zhu, Qili Liu, Mark N. Wu, Yan Li
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114282- (2024)
Summary: The suppressive effect of insulin on food intake has been documented for decades. However, whether insulin signals can encode a certain type of nutrients to regulate nutrient-specific feeding behavior remains elusive. Here, we show that in f
Externí odkaz:
https://doaj.org/article/53bd41be728049cbbf6c982a396fd409
Autor:
Qiang Liu, Benjamin J. Bell, Dong Won Kim, Sang Soo Lee, Mehmet F. Keles, Qili Liu, Ian D. Blum, Annette A. Wang, Elijah J. Blank, Jiali Xiong, Joseph L. Bedont, Anna J. Chang, Habon Issa, Jeremiah Y. Cohen, Seth Blackshaw, Mark N. Wu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Circadian clocks generate rhythms of arousal, but the underlying molecular and cellular mechanisms remain unclear. In Drosophila, the clock output molecule WIDE AWAKE (WAKE) labels rhythmic neural networks and cyclically regulates sleep and
Externí odkaz:
https://doaj.org/article/8234d36b2f9147ce8f1a2a29b89103bf
Autor:
Jill A. Rabinowitz, Yang An, Linchen He, Alfonso J. Alfini, Vadim Zipunnikov, Mark N. Wu, Sarah K. Wanigatunga, Jennifer A. Schrack, Chandra L. Jackson, Luigi Ferrucci, Eleanor M. Simonsick, Susan M. Resnick, Adam P. Spira
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
ObjectivesWrist actigraphs (accelerometers) can record motor activity over multiple days and nights. The resulting data can be used to quantify 24-h activity profiles, known as circadian rest-activity rhythms (CRARs). Actigraphic CRARs have been tied
Externí odkaz:
https://doaj.org/article/39078cc9f6064e20b3371ed7df2d5154
Autor:
Jocelynn T Owusu, Jill A Rabinowitz, Marian Tzuang, Yang An, Melissa Kitner-Triolo, Vadim Zipunnikov, Mark N Wu, Sarah K Wanigatunga, Jennifer A Schrack, Roland J Thorpe, Eleanor M Simonsick, Luigi Ferrucci, Susan M Resnick, Adam P Spira
Publikováno v:
The Journals of Gerontology: Series A. 78:454-462
Background This study examined associations of actigraphy-estimated sleep parameters with concurrent and future cognitive performance in adults aged ≥ 50 years and explored interactions with race. Methods Participants were 435 cognitively normal ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aab7456f61a56b89b613939e52ced5b
https://doi.org/10.1093/gerona/glac180
https://doi.org/10.1093/gerona/glac180
Publikováno v:
J Comp Neurol
Structure-function analyses of the mammalian brain have historically relied on anatomically-based approaches. In these investigations, physical, chemical, or electrolytic lesions of anatomical structures are applied, and the resulting behavioral or p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d313733bdc9cd63553a2e6591483ff8
https://doi.org/10.1002/cne.25066
https://doi.org/10.1002/cne.25066
Autor:
Kevin R. Murphy, Vadim N. Gladyshev, Anthony Cammarato, Holly M. Isbell, Bruno Manta, Klitos Konstantinidis, Mario A. Bianchet, Fujian Lu, Meera C. Viswanathan, Lo Lai, Elizabeth D. Luczak, Donghui Zhang, Vassilios J. Bezzerides, Jonathan M. Granger, Rodney L. Levine, Thomas J. Hund, Qiang Wang, Mark N. Wu, William T. Pu, Madeline A. Shea, Alex L. Kolodkin, Daniel Gratz, Ian D. Blum, Danielle A. Heims-Waldron, An-Chi Wei, Mark E. Anderson, Qinchuan Wang, Yuejin Wu
Publikováno v:
J Clin Invest
Oxidant stress can contribute to health and disease. Here we show that invertebrates and vertebrates share a common stereospecific redox pathway that protects against pathological responses to stress, at the cost of reduced physiological performance,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a80e0f446ebb142a4cde4b056e2bd9
https://doi.org/10.1172/jci133181
https://doi.org/10.1172/jci133181
Autor:
Adam P. Spira, Paul A. Rosenberg, Vadim Zipunnikov, Mark N. Wu, Sarah K. Wanigatunga, John D. Outen
Publikováno v:
The American Journal of Geriatric Psychiatry. 29:S111-S113
Introduction Neuropsychiatric symptoms (NPS) affect nearly all individuals with AD. Agitation in AD (Agit-AD) is one of the most common NPS, with an estimated prevalence over 40%. Agit-AD is a major cause of distress and burden for AD caregivers and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c40dc06f69163368c33b9fe47f4370
https://doi.org/10.1016/j.jagp.2021.01.108
https://doi.org/10.1016/j.jagp.2021.01.108