Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Mark N Cruickshank"'
Autor:
Jonathan Chee, Chelsea Wilson, Anthony Buzzai, Ben Wylie, Catherine A Forbes, Mitchell Booth, Nicola Principe, Bree Foley, Mark N Cruickshank, Jason Waithman
Publikováno v:
Epigenetics, Vol 15, Iss 1-2, Pp 134-144 (2020)
Activation of naïve CD8+ T cells stimulates proliferation and differentiation into cytotoxic T-lymphocytes (CTLs). Adoptive T Cell Therapy (ACT) involves multiple rounds of ex vivo activation to generate enough CTLs for reinfusion into patients, but
Externí odkaz:
https://doaj.org/article/d828f4c443114fb39e8b6402758650c5
Autor:
Ben Wylie, Jonathan Chee, Catherine A Forbes, Mitchell Booth, Shane R Stone, Anthony Buzzai, Ana Abad, Bree Foley, Mark N Cruickshank, Jason Waithman
Publikováno v:
OncoImmunology, Vol 8, Iss 8 (2019)
Immunotherapies such as adoptive cell therapy (ACT) are promising treatments for solid cancers. However, relapsing disease remains a problem and the molecular mechanisms underlying resistance are poorly defined. We postulated that the deregulated epi
Externí odkaz:
https://doaj.org/article/015bc4022d6743b583d6c539faf9ecf0
Autor:
Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda, Akiho Tsuchiya, Xiaonan Wang, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Ryo Akazawa, Itaru Kato, Takashi Mikami, Kentaro Watanabe, Masahiro Sekiguchi, Masafumi Seki, Shunsuke Kimura, Mitsuteru Hiwatari, Motohiro Kato, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Akinori Kanai, Toshiya Inaba, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Rishi S. Kotecha, Mark N. Cruickshank, Fumihiko Ishikawa, Tomohiro Morio, Mariko Eguchi, Takao Deguchi, Nobutaka Kiyokawa, Yuki Arakawa, Katsuyoshi Koh, Yuki Aoki, Takashi Ishihara, Daisuke Tomizawa, Takako Miyamura, Eiichi Ishii, Shuki Mizutani, Nicola K. Wilson, Berthold Göttgens, Satoru Miyano, Toshio Kitamura, Susumu Goyama, Akihiko Yokoyama, Hiroyuki Aburatani, Seishi Ogawa, Junko Takita
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The molecular heterogeneity of KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) remains poorly characterised. Here, the authors perform multi-omics analysis for 84 ALL patients and suggest 5 distinct subgroups for risk stratification and pe
Externí odkaz:
https://doaj.org/article/7fee3de7cd6b4b10b237a1df0b62b1d6
Autor:
Laurence C. Cheung, Mark N. Cruickshank, Anastasia M. Hughes, Sajla Singh, Grace-Alyssa Chua, Jette Ford, Emanuela Ferrari, Joyce Oommen, Sébastien Malinge, Richard B. Lock, Ursula R. Kees, Rishi S. Kotecha
Publikováno v:
Haematologica, Vol 104, Iss 7 (2019)
Externí odkaz:
https://doaj.org/article/cba2b8faa6fb49ab9ba6b16a74816c84
Autor:
Ben Wylie, James Read, Anthony C. Buzzai, Teagan Wagner, Niamh Troy, Genevieve Syn, Shane R. Stone, Bree Foley, Anthony Bosco, Mark N. Cruickshank, Jason Waithman
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Conventional dendritic cells (cDC) resident in the lymphoid organs of mice have been classically divided into CD8+ and CD8neg subsets. It is well-established that CD8+ dendritic cells (DCs) and their migratory counterparts in the periphery comprise t
Externí odkaz:
https://doaj.org/article/950fd7ab1e254371b596121a74444144
Autor:
James F. Read, Michael Serralha, Jesse Armitage, Muhammad Munir Iqbal, Mark N. Cruickshank, Alka Saxena, Deborah H. Strickland, Jason Waithman, Patrick G. Holt, Anthony Bosco
Human perinatal life is characterized by a period of extraordinary change during which newborns encounter abundant environmental stimuli and exposure to potential pathogens. To meet such challenges, the neonatal immune system is equipped with unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db32b3bbf84fa80ab92226fc1400d76f
https://doi.org/10.1101/2023.05.18.541356
https://doi.org/10.1101/2023.05.18.541356
Autor:
Jessica Cheng, Elizabeth Quail, Mark N. Cruickshank, Han Leng Ng, Rhonda L. Taylor, Daniela Ulgiati, Lawrence J. Abraham
Publikováno v:
Molecular Immunology. 128:150-164
During mammalian lymphoid development, Notch signaling is necessary at multiple stages of T lymphopoiesis, including lineage commitment, and later stages of T cell effector differentiation. In contrast, outside of a defined role in the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2ec67be2da06523f631b0efafd3b3b
https://doi.org/10.1016/j.molimm.2020.10.001
https://doi.org/10.1016/j.molimm.2020.10.001
Autor:
Laurence C. Cheung, Carlos Aya-Bonilla, Mark N. Cruickshank, Sung K. Chiu, Vincent Kuek, Denise Anderson, Grace-Alyssa Chua, Sajla Singh, Joyce Oommen, Emanuela Ferrari, Anastasia M. Hughes, Jette Ford, Elena Kunold, Maria C. Hesselman, Frederik Post, Kelly E. Faulk, Erin H. Breese, Erin M. Guest, Patrick A. Brown, Mignon L. Loh, Richard B. Lock, Ursula R. Kees, Rozbeh Jafari, Sébastien Malinge, Rishi S. Kotecha
Publikováno v:
Leukemia.
Infants with KMT2A-rearranged B-cell acute lymphoblastic leukemia (ALL) have a dismal prognosis. Survival outcomes have remained static in recent decades despite treatment intensification and novel therapies are urgently required. KMT2A-rearranged in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3511827709e3b75fa6fcbd43736a54e
https://pubmed.ncbi.nlm.nih.gov/36380143
https://pubmed.ncbi.nlm.nih.gov/36380143
Autor:
Katherine M. Audsley, Vanessa S. Fear, Alison M. McDonnell, Tsuneyasu Kaisho, Anthony Buzzai, Mark N. Cruickshank, Ben Wylie, Samantha Barnes, Teagan Wagner, Jesse D. Armitage, Anthony Bosco, Jason Waithman, Hannah V. Newnes, Bree Foley, Clara Ta
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Cancer vaccination drives the generation of anti-tumor T cell immunity and can be enhanced by the inclusion of effective immune adjuvants such as type I interferons (IFNs). Whilst type I IFNs have been shown to promote cross-priming of T cells, the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162c6cb60a4498be809c8e05e193aad5
Publikováno v:
Biomolecules, Vol 11, Iss 849, p 849 (2021)
Biomolecules
Biomolecules
Notch signaling forms an evolutionarily conserved juxtacrine pathway crucial for cellular development. Initially identified in Drosophila wing morphogenesis, Notch signaling has since been demonstrated to play pivotal roles in governing mammalian cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441da4d3f4e5fd4dfe60782a5563e855
http://hdl.handle.net/10044/1/89846
http://hdl.handle.net/10044/1/89846