Bacterial aggregation facilitates internalin-mediated invasion of Listeria monocytogenes

Autor: Liam Feltham, Josephine Moran, Marie Goldrick, Elizabeth Lord, David G. Spiller, Jennifer S. Cavet, Mark Muldoon, Ian. S. Roberts, Pawel Paszek

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Dissemination of food-borne L. monocytogenes in the host relies on internalin-mediated invasion, but the underlying invasion strategies remain elusive. Here we use live-cell microscopy to follow single cell interactions between individual human cells

Externí odkaz: https://doaj.org/article/6f37f87fb20348498905d94b4d73c328

Modelling and classifying joint trajectories of self-reported mood and pain in a large cohort study.

Autor: Rajenki Das, Mark Muldoon, Mark Lunt, John McBeth, Belay Birlie Yimer, Thomas House

Publikováno v: PLOS Digital Health, Vol 2, Iss 3, p e0000204 (2023)

It is well-known that mood and pain interact with each other, however individual-level variability in this relationship has been less well quantified than overall associations between low mood and pain. Here, we leverage the possibilities presented b

Externí odkaz: https://doaj.org/article/272d8f6cd1a24e908be019d5dd08cccd

Two-phase modelling of air bubbles in ice cream

Autor: Peter Howell, Mark Muldoon

Ice cream is essentially a foam consisting of air bubbles dispersed in a mixture of fat, water and ice crystals. The air fraction is typically around 50% by volume, and this is crucial for the product to have the consistency and texture desired by cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62034796eec2ab2f01d4dfb65e9d05c9
https://doi.org/10.33774/miir-2021-fb24s

Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling

Autor: Pawel Paszek, Christopher M. Clark, Dean A. Jackson, Nissrin Alachkar, James Bagnall, James Roberts, Mark Muldoon, Hazel England, Mark Platt, William Rowe

Publikováno v: Bagnall, J, Rowe, W, Alachkar, N, Roberts, J, England, H, Clark, C, Platt, M, Jackson, D, Muldoon, M & Paszek, P 2020, ' Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling ', Cell Systems, vol. 11, no. 3, pp. 300-314.e8 . https://doi.org/10.1016/j.cels.2020.08.007

Summary Single-cell gene expression is inherently variable, but how this variability is controlled in response to stimulation remains unclear. Here, we use single-cell RNA-seq and single-molecule mRNA counting (smFISH) to study inducible gene express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895227e99b0e9bf89e5f102871fee92e
https://doi.org/10.1016/j.cels.2020.08.007

Antigenicity and Immunogenicity of Transmitted/Founder, Consensus, and Chronic Envelope Glycoproteins of Human Immunodeficiency Virus Type 1

Autor: Alan Lapedes, R. Swanstrom, Julie Blinn, Andrew Foulger, Chun-Yen Tsao, Sydeaka Watson, Mark Muldoon, Hua-Xin Liao, Beatrice H. Hahn, Richard M. Scearce, Bette T. Korber, Xiaozhi Lu, Robert Parks, Shi-Mao Xia, Ben-Jiang Ma, George M. Shaw, Laura L. Sutherland, Haiyan Chen, Barton F. Haynes, Feng Gao, Cindy M. Bowman, Nathan Vandergrift, S. Munir Alam, David C. Montefiori

Publikováno v: Journal of Virology. 87:4185-4201

Human immunodeficiency virus type 1 (HIV-1) vaccine development requires selection of appropriate envelope (Env) immunogens. Twenty HIV-1 Env glycoproteins were examined for their ability to bind human anti-HIV-1 monoclonal antibodies (MAbs) and then

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876ddf580068f4c220c8359bbe6418c1
https://doi.org/10.1128/jvi.02297-12