Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Mark Mirochnick"'
Autor:
Xiaomei I. Liu, André Dallmann, Kristina Brooks, Brookie M. Best, Diana F. Clarke, Mark Mirochnick, John N. van denAnker, Edmund V. Capparelli, Jeremiah D. Momper
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 148-153 (2023)
Abstract Pregnant individuals are at high risk for severe illness from COVID‐19, and there is an urgent need to identify safe and effective therapeutics for this population. Remdesivir (RDV) is a SARS‐CoV‐2 nucleotide analog RNA polymerase inhi
Externí odkaz:
https://doaj.org/article/d52f04c0444447639aa5582982613a39
Autor:
Sherry Zhao, Mary Gockenbach, Manuela Grimstein, Hari Cheryl Sachs, Mark Mirochnick, Kimberly Struble, Yodit Belew, Jian Wang, Edmund V. Capparelli, Brookie M. Best, Tamara Johnson, Jeremiah D. Momper, Anil R. Maharaj
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Background: Alterations in plasma protein concentrations in pregnant and postpartum individuals can influence antiretroviral (ARV) pharmacokinetics. Physiologically-based pharmacokinetic (PBPK) models can serve to inform drug dosing decisions in unde
Externí odkaz:
https://doaj.org/article/255de7edd5bf4599bab6e29d0798c310
Autor:
Jos Lommerse, Diana Clarke, Thomas Kerbusch, Henri Merdjan, Han Witjes, Hedy Teppler, Mark Mirochnick, Edward P. Acosta, Larissa Wenning, Sharon Nachman, Anne Chain
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 9, Pp 643-653 (2019)
Raltegravir readily crosses the placenta to the fetus with maternal use during pregnancy. After birth, neonatal raltegravir elimination is highly variable and often extremely prolonged, with some neonates demonstrating rising profiles after birth des
Externí odkaz:
https://doaj.org/article/e0b66d5f0a014bd788ec368d457eb18d
Autor:
Kristina Adachi, Jiahong Xu, Nava Yeganeh, Margaret Camarca, Mariza G Morgado, D Heather Watts, Lynne M Mofenson, Valdilea G Veloso, Jose Henrique Pilotto, Esau Joao, Glenda Gray, Gerhard Theron, Breno Santos, Rosana Fonseca, Regis Kreitchmann, Jorge Pinto, Marisa M Mussi-Pinhata, Mariana Ceriotto, Daisy Maria Machado, Yvonne J Bryson, Beatriz Grinsztejn, Jack Moye, Jeffrey D Klausner, Claire C Bristow, Ruth Dickover, Mark Mirochnick, Karin Nielsen-Saines, NICHD HPTN 040 Study Team
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0189851 (2018)
BACKGROUND:Sexually transmitted infections (STIs) including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Treponema pallidum (TP), and cytomegalovirus (CMV) may lead to adverse pregnancy and infant outcomes. The role of combined maternal ST
Externí odkaz:
https://doaj.org/article/c219fddeb53d4b9e917faa46a8c7843f
Autor:
Nikki Mulligan, Stein Schalkwijk, Brookie M. Best, Angela Colbers, Jiajia Wang, Edmund V. Capparelli, José Moltó, Alice M. Stek, Graham Taylor, Elizabeth Smith, Carmen Hidalgo-Tenorio, Nahida Chakhtoura, Marjo van Kasteren, Courtney V. Fletcher, Mark Mirochnick, David Burger
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Background: The study goal was to describe etravirine pharmacokinetics during pregnancy and postpartum in HIV-infected women. Methods: IMPAACT P1026s and PANNA are on-going, nonrandomized, open-label, parallel-group, multi-center phase-IV prospective
Externí odkaz:
https://doaj.org/article/0c31abb7797a4660a458252de78686a0
Publikováno v:
Obstetrics and Gynecology Clinics of North America. 50:205-218
Publikováno v:
New England Journal of Medicine. 388:344-356
Autor:
Xiaomei I. Liu, André Dallmann, Kristina Brooks, Brookie M. Best, Diana F. Clarke, Mark Mirochnick, John N. van den Anker, Edmund V. Capparelli, Jeremiah D. Momper
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 12:148-153
Autor:
Conrado Milani, Coutinho, Meredith G, Warshaw, Geraldo, Duarte, Alice, Stek, Avy, Violari, Cristina B, Hofer, Jaime G, Deville, James Samwel, Ngocho, José Henrique, Pilotto, Mario Dias, Correa, David E, Shapiro, Trevon L, Fuller, Nahida, Chakhtoura, Mark, Mirochnick, Esaú C, João
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 91:403-409
Integrase inhibitors have been associated with excess gestational weight gain that may lead to adverse pregnancy outcomes (APOs). This post hoc analysis of NICHD P1081 compared antepartum changes in weight and body mass index (BMI) in pregnant women
Autor:
Tom G Jacobs, Stef Schouwenburg, Martina Penazzato, Moherndran Archary, Theodore D Ruel, John van den Anker, David M Burger, Tim R Cressey, Elaine J Abrams, Hermione Lyall, Adrie Bekker, Angela Colbers, David Burger, Tim Cressey, Deborah Hirt, Irja Lutsar, Helen Mcilleron, Joe Standing, John Van den Anker, Elin Svensson, Elaine Abrams, Pauline Amuge, Mo Archary, Yodit Belew, Brookie Best, Helen Bygrave, Edmund Capparelli, Esther Casas, Diana Clarke, Polly Clayden, Mutsa Dangarembizi, Roberto De Lisa, Paolo Denti, Paul Domanico, Shaffiq Essajee, Lisa Frigati, Carlo Giaquinto, Diana Gibb, Stephanie Hackett, Rohan Hazra, Marc Lallemant, Linda Lewis, Shahin Lockman, Imelda Mahaka, Betsy McFarland, Cathal Meere, Fatima Mir, Mark Mirochnick, Lynne Mofenson, Irene Mukui, Angela Mushavi, Victor Musiime, Eleanor Namusoke-Magongo, Elisabeth Obimbo, Mary Atieno Ojoo, Roger Parades, Carmen Perez-Casas, Manuele Piccolis, Jorge Pinto, Thanyawee Puthanakit, Natella Rakhmanina, Annette Reinisch, Pablo Rojo, Vanessa Rouzier, Ted Ruel, Nadia Sam-Agudu, George Siberry, Teresa Simione, Katie Simon, Vindi Singh, Manjari Solares, Nandita Sugandhi, Mariam Sylla, Ibou Thior, Anna Turkova, Marissa Vicari, Jenny Walsh, Melynda Watkins, Hilary Wolf, Asma Hafiz, Ajay Rangaraj, Meg Doherty, Marco Vitoria
Publikováno v:
The Lancet HIV, 9, 9, pp. e649-e657
The Lancet HIV, 9, e649-e657
The Lancet HIV, 9, e649-e657
Item does not contain fulltext Although 23 antiretroviral drugs are approved for use in adults, only six are approved by regulatory authorities for use in term neonates born to women with HIV, with even fewer options for preterm neonates. A major hur