Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Mark Michalak"'
Autor:
Eric R. Goedken, Wilson Noel S, Sage E. Foley, Christopher M. Harris, Sara Murdock, Mark Michalak
Publikováno v:
SLAS Discovery. 23:1040-1050
In vitro analysis of covalent inhibitors requires special consideration, due to the time-dependent and typically irreversible nature of their target interaction. While many analyses are reported for the characterization of a final candidate, it is le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072debe51808c8101f1bca96e6869e63
https://doi.org/10.1177/2472555218787445
https://doi.org/10.1177/2472555218787445
Autor:
Ihle David C, Eric R. Goedken, Jonathan S. George, Medha J. Tomlinson, David Banach, Douglas Marcotte, Christopher M. Harris, Bryan A. Fiamengo, Maria A. Argiriadi, Sage E. Foley, Sara Murdock, Mark Michalak, Jeffrey W. Voss, Philip Merta, Kristine E. Frank, Adrian D. Hobson
Publikováno v:
Journal of Biological Chemistry. 290:4573-4589
The action of Janus kinases (JAKs) is required for multiple cytokine signaling pathways, and as such, JAK inhibitors hold promise for treatment of autoimmune disorders, including rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e524e4fd612d04811684b59ffb7cd9
https://doi.org/10.1074/jbc.m114.595181
https://doi.org/10.1074/jbc.m114.595181
Autor:
Medha J. Tomlinson, Subramanya Hegde, David H. Lee, Hua Tang, Jacqueline Lee, Cheryl Yi-Pin Lee, Lucia Eaton, Shaun M. McLoughlin, Nidhi Gaur, Dongdong Wang, Bohdan Harvey, Mark Michalak, Boris Labkovsky, Qing Chang, Tariq Ghayur, Qingfeng Tao, Arun B. Deora, Chee-Ho Choi
Publikováno v:
mAbs
TNF-α (TNF), a pro-inflammatory cytokine is synthesized as a 26 kDa protein, anchors in the plasma membrane as transmembrane TNF (TmTNF), and is subjected to proteolysis by the TNF-α converting enzyme (TACE) to release the 15 kDa form of soluble TN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8658de63d62017508709ba4cb49112
https://pubmed.ncbi.nlm.nih.gov/28323513
https://pubmed.ncbi.nlm.nih.gov/28323513