Corrigendum: An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis

Autor: Alexander Vugler, James O’connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicolas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Zhaoning Zhu, Daniel Brookings, Helen Horsley, Jag Heer, Laurent Schio, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Externí odkaz: https://doaj.org/article/7c28a2cfd57b43f5bbbad3d413464f30

A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours

Autor: N Cresti, Karen E Swales, Mark Merriman, Rodger A. Allen, Paul Bevan, Carola Mala, Richard H. Wilson, Alan V. Boddy, Malcolm R Ranson, T. R. Jeffery Evans, Alastair Greystoke, Vicky M. Coyle, Ruth Plummer, Yvette Drew, Julieann Sludden, Alan Anthoney, Lisa Jane Rodgers, MJ Griffin, David Jamieson, Udai Banerji, Emma Dean, Markus Buerkle

Publikováno v: Jamieson, D, Griffin, M, Sludden, J, Drew, Y, Cresti, N, Swales, K, Merriman, M, Allen, R, Bevan, P, Buerkle, M, Mala, C, Coyle, V, Rodgers, L, Dean, E, Greystoke, A, Banerji, U, Wilson, R, Evans, J, Anthoney, A, Ranson, M, Boddy, A & Plummer, R 2016, ' A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours ', European Journal of Cancer, vol. 68 . https://doi.org/10.1016/j.ejca.2016.08.026
Jamieson, D, Griffin, M J, Sludden, J, Drew, Y, Cresti, N, Swales, K, Merriman, M, Allen, R, Bevan, P, Buerkle, M, Mala, C, Coyle, V, Rodgers, L, Dean, E, Greystoke, A, Banerji, U, Wilson, R H, Evans, T R J, Anthoney, A, Ranson, M, Boddy, A V & Plummer, R 2016, ' A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours ', European Journal of Cancer, vol. 68, pp. 1-10 . https://doi.org/10.1016/j.ejca.2016.08.026

Purpose:\ud \ud We performed a multi-centre phase I study to assess the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of the orally available small molecule mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor, WX-554, and to determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cfeb7e3462ba1cdff56aeaf39e4fa01
https://doi.org/10.1016/j.ejca.2016.08.026

Development of a recombinant cell-based system for the characterisation of phosphodiesterase 4 isoforms and evaluation of inhibitors

Autor: Martin J. Perry, Mark Merriman, Rodger A. Allen, Raymond J. Owens

We described the development of a recombinant cell-based system for the characterisation of phosphodiesterase (PDE) 4 isoforms and the evaluation of inhibitors. The Chinese hamster ovary (CHO) cell, which was found to have a low endogenous PDE4 backg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13807d3bb58932317f9a807fb213b044
https://doi.org/10.1016/s0006-2952(99)00062-3

4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase

Autor: Ian Whitcombe, Mark Merriman, Sara Wright, Frank Driessens, Rikki Peter Alexander, Karen Viviane Lucile Crépy, Claire Louise Kulisa, Ahrani Balasundaram, Daniel Christopher Brookings, Ted A.H. Parton, James Petrie Turner, Sue Harris, Marie-France Deltent, Gillian Hutchinson, Andrew W. Gill, Mark James Batchelor, Prakash Mistry, Tom Crabbe

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:4316-4320

4-(1,3-Thiazol-2-yl)morpholine derivatives have been identified as potent and selective inhibitors of phosphoinositide 3-kinase. The SAR data of selected examples are presented and the in vivo profiling of compound 18 is shown to demonstrate the util

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea09142b3bedc2b266d15a6185af0e2
https://doi.org/10.1016/j.bmcl.2008.06.076

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