Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Mark Mercola"'
Autor:
Sacha V. Kepreotis, Jae Gyun Oh, Mina Park, Jimeen Yoo, Cholong Lee, Mark Mercola, Roger J. Hajjar, Dongtak Jeong
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102174- (2024)
Dystrophic cardiomyopathy is a significant feature of Duchenne muscular dystrophy (DMD). Increased cardiomyocyte cytosolic calcium (Ca2+) and interstitial fibrosis are major pathophysiological hallmarks that ultimately result in cardiac dysfunction.
Externí odkaz:
https://doaj.org/article/1cc3305bec1144ec93e2670c9a1ac745
Autor:
Orlando Chirikian, William R. Goodyer, Elda Dzilic, Vahid Serpooshan, Jan W. Buikema, Wesley McKeithan, HaoDi Wu, Guang Li, Soah Lee, Markus Merk, Francisco Galdos, Aimee Beck, Alexandre J. S. Ribeiro, Sharon Paige, Mark Mercola, Joseph C. Wu, Beth L. Pruitt, Sean M. Wu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Generating cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) has represented a significant advance in our ability to model cardiac disease. Current differentiation protocols, however, have limited use due to their produ
Externí odkaz:
https://doaj.org/article/d5033e1c1320405bbdfe19a5a5ff8a89
Autor:
Nirmal Vadgama, Alexander Kreymerman, Jackie Campbell, Olga Shamardina, Christiane Brugger, Genomics England Research Consortium, Alexandra M. Deaconescu, Richard T. Lee, Christopher J. Penkett, Casey A. Gifford, Mark Mercola, Jamal Nasir, Ioannis Karakikes
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
There is considerable variability in the susceptibility and progression for COVID-19 and it appears to be strongly correlated with age, gender, ethnicity and pre-existing health conditions. However, to our knowledge, cohort studies of COVID-19 in cli
Externí odkaz:
https://doaj.org/article/5fed2a6db2fc4920b5237d99001a449c
Autor:
Jorge Gomez‐Galeno, Karl Okolotowicz, Mark Johnson, Wesley L. McKeithan, Mark Mercola, John R. Cashman
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract Prolongation of the cardiac action potential (AP) and early after depolarizations (EADs) are electrical anomalies of cardiomyocytes that can lead to lethal arrhythmias and are potential liabilities for existing drugs and drug candidates in d
Externí odkaz:
https://doaj.org/article/0aa03a93ca524ad2bceee95b8a4542e8
Autor:
Zhiyong Lei, Christine Wahlquist, Hamid el Azzouzi, Janine C. Deddens, Diederik Kuster, Alain van Mil, Agustin Rojas-Munoz, Manon M. Huibers, Mark Mercola, Roel de Weger, Jolanda Van der Velden, Junjie Xiao, Pieter A. Doevendans, Joost P. G. Sluijter
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Compromised cardiac function is a hallmark for heart failure, mostly appearing as decreased contractile capacity due to dysregulated calcium handling. Unfortunately, the underlying mechanism causing impaired calcium handling is still not fully unders
Externí odkaz:
https://doaj.org/article/e8911eb526d44c128a96bcd2108ada95
Autor:
Aviva Levitas, Emad Muhammad, Yuan Zhang, Isaac Perea Gil, Ricardo Serrano, Nashielli Diaz, Maram Arafat, Alexandra A Gavidia, Michael S Kapiloff, Mark Mercola, Yoram Etzion, Ruti Parvari, Ioannis Karakikes
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1009000 (2020)
Dilated cardiomyopathy (DCM) is a common cause of heart failure and sudden cardiac death. It has been estimated that up to half of DCM cases are hereditary. Mutations in more than 50 genes, primarily autosomal dominant, have been reported. Although r
Externí odkaz:
https://doaj.org/article/d5b2baa88b9047f9b0556780536f082f
Autor:
Jonas Halver, Kristin Wenzel, Jandirk Sendker, Carmen Carrillo García, Clemens A. J. Erdelmeier, Erik Willems, Mark Mercola, Nico Symma, Stephanie Könemann, Egon Koch, Andreas Hensel, Dennis Schade
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Extracts from the leaves and flowers of Crataegus spp. (i.e., hawthorn species) have been traditionally used with documented preclinical and clinical activities in cardiovascular medicine. Based on reported positive effects on heart muscle after isch
Externí odkaz:
https://doaj.org/article/0eb15241d18c4abfbc33eef98723e5c2
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226694 (2019)
Gene editing strategies, such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9), are revolutionizing biology. However, quantitati
Externí odkaz:
https://doaj.org/article/66618dd24c3e40f2b10ede8a670f96cd
Autor:
Ramón Díaz-Trelles, Maria Cecilia Scimia, Paul Bushway, Danh Tran, Anna Monosov, Edward Monosov, Kirk Peterson, Stacey Rentschler, Pedro Cabrales, Pilar Ruiz-Lozano, Mark Mercola
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Heart function after injury improves upon formation of new blood vessels. Here, the authors show that ablating a transcription factor RBPJ in the murine heart increases vascularization and maintains cardiac function after injury by increasing respons
Externí odkaz:
https://doaj.org/article/659bd0f4ce584ff8ab4fcf19cbaacd4d
Autor:
Joaquim Cabral-Teixeira, Almudena Martinez-Fernandez, Wenqing Cai, Andre Terzic, Mark Mercola, Erik Willems
Publikováno v:
Stem Cell Research, Vol 15, Iss 1, Pp 88-95 (2015)
Aside from its role in cell membrane integrity, cholesterol is a key component in steroid hormone production. The vital functions of steroid hormones such as estrogen, testosterone, glucocorticoids (Gcrts) and mineralocorticoids (Mnrts) in perinatal
Externí odkaz:
https://doaj.org/article/d4849eae2cf74b3698dd6d3b79b1ba79