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Fish oil (FO) targets lipid microdomain organization to suppress T-cell and macrophage function; however, little is known about this relationship with B cells, especially at the animal level. We previously established that a high FO dose diminished m

Externí odkaz: https://doaj.org/article/47cccc12b46c4212958327549d8ec860

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Angiotensin AT1 receptor inhibition, angiotensin-converting enzyme inhibition, and combination therapy with developing heart failure: Cellular mechanisms of action

Autor: Francis G. Spinale, Marc de Gasparo, Julie P. Iannini, Rupak Mukherjee, D. Mark Melton

Publikováno v: Journal of Cardiac Failure. 4:325-332

Background: Past studies have shown that angiotensin-converting enzyme inhibition (ACEI) alone, angiotensin AT1 receptor blockade (AT1 block) alone, and combined treatment have differential effects on left ventricular (LV) function and geometry with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605b964e9fed9e3599a115c3e3a140c0
https://doi.org/10.1016/s1071-9164(98)90238-x

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Modulation of the Renin-Angiotensin Pathway Through Enzyme Inhibition and Specific Receptor Blockade in Pacing-Induced Heart Failure

Autor: Marc de Gasparo, Steve Whitebread, D. Mark Melton, Julie P. Iannini, Montgomery H. Cox, Patrick B. Thomas, Francis G. Spinale, Mark J. Clair, Rupak Mukherjee, Latha Hebbar

Publikováno v: Circulation. 96:2397-2406

Background The goal of this study was to determine the effects of ACE inhibition alone, AT 1 angiotensin (Ang) II receptor blockade alone, and combined ACEI and AT 1 Ang II receptor blockade in a model of congestive heart failure (CHF) on isolated LV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07df6115021ddcdba1209ebb14697290
https://doi.org/10.1161/01.cir.96.7.2397

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Modulation of the Renin-Angiotensin Pathway Through Enzyme Inhibition and Specific Receptor Blockade in Pacing-Induced Heart Failure

Autor: Francis G. Spinale, Marc de Gasparo, Steve Whitebread, Latha Hebbar, Mark J. Clair, D. Mark Melton, R. Stephen Krombach, Rupak Mukherjee, Julie P. Iannini, Seung-Jun O

Publikováno v: Circulation. 96:2385-2396

Background The goal of this study was to determine the effects of ACE inhibition (ACEI) alone, AT 1 angiotensin (Ang) II receptor blockade alone, and combined ACEI and AT 1 Ang II receptor blockade on LV function, systemic hemodynamics, and neurohorm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7a282b4e05348952ff8554db7fe48a
https://doi.org/10.1161/01.cir.96.7.2385

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Fish oil disrupts MHC class II lateral organization on the B-cell side of the immunological synapse independent of B-T cell adhesion

Autor: Lance C. Bridges, Mitchel Harris, Benjamin Drew Rockett, Mark Melton, Saame Raza Shaikh

Fish oil-enriched long chain n-3 polyunsaturated fatty acids disrupt the molecular organization of T-cell proteins in the immunological synapse. The impact of fish oil derived n-3 fatty acids on antigen-presenting cells, particularly at the animal le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c889d36e94a1f546efe39c25f886d0b
https://europepmc.org/articles/PMC3785547/

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