Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Mark Mcclellan"'
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Clinical evidence generation from and for representative populations can be improved through increased research access and ease of trial participation. To improve access and participation, a modern trial infrastructure is needed that broaden
Externí odkaz:
https://doaj.org/article/d6ef32d1a3374beba3d8a5a13bb22b93
Autor:
Christina Silcox, Eyal Zimlichmann, Katie Huber, Neil Rowen, Robert Saunders, Mark McClellan, Charles N. Kahn, Claudia A. Salzberg, David W. Bates
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-3 (2024)
Abstract Artificial intelligence (AI) has the potential to transform care delivery by improving health outcomes, patient safety, and the affordability and accessibility of high-quality care. AI will be critical to building an infrastructure capable o
Externí odkaz:
https://doaj.org/article/337ca9281db34dc8bf133c98e5ffd7d0
Autor:
Samuel J Gonzalez, Julia M Heckel, Rebecca R Goldblum, Taylor A Reid, Mark McClellan, Melissa K Gardner
Publikováno v:
eLife, Vol 13 (2024)
EB1 is a key cellular protein that delivers regulatory molecules throughout the cell via the tip-tracking of growing microtubule plus-ends. Thus, it is important to understand the mechanism for how EB1 efficiently tracks growing microtubule plus-ends
Externí odkaz:
https://doaj.org/article/6032f75d380e495b9a0e30f81c2e60d2
Autor:
Brystana G. Kaufman, Rebecca Whitaker, Nirosha Mahendraratnam, Sophie Hurewitz, Jeremy Yi, Valerie A. Smith, Mark McClellan
Publikováno v:
BMC Public Health, Vol 21, Iss 1, Pp 1-6 (2021)
Abstract Background The novel coronavirus disease 2019 (COVID-19) sickened over 20 million residents in the United States (US) by January 2021. Our objective was to describe state variation in the effect of initial social distancing policies and non-
Externí odkaz:
https://doaj.org/article/a04305d6365145aa994066eceed8850d
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
During mitosis, tension at the centromere occurs from the spindle but the role of centromere mechanics in controlling metaphase tension is poorly understood. Here, the authors report that mechanical stiffnness of the centromere matures during mitotic
Externí odkaz:
https://doaj.org/article/a1b34f1f953d4020baee46b51bcab555
Autor:
Taylor A Reid, Courtney Coombes, Soumya Mukherjee, Rebecca R Goldblum, Kyle White, Sneha Parmar, Mark McClellan, Marija Zanic, Naomi Courtemanche, Melissa K Gardner
Publikováno v:
eLife, Vol 8 (2019)
The microtubule binding protein EB1 specifically targets the growing ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins with microtubule plus-ends. Microtubule end targeting of EB1 has been attributed to high-a
Externí odkaz:
https://doaj.org/article/d7a91c61f2ff4eafb4d0d87904122323
Autor:
Carrie Ketel, Helen S W Wang, Mark McClellan, Kelly Bouchonville, Anna Selmecki, Tamar Lahav, Maryam Gerami-Nejad, Judith Berman
Publikováno v:
PLoS Genetics, Vol 5, Iss 3, p e1000400 (2009)
Centromeres are critically important for chromosome stability and integrity. Most eukaryotes have regional centromeres that include long tracts of repetitive DNA packaged into pericentric heterochromatin. Neocentromeres, new sites of functional kinet
Externí odkaz:
https://doaj.org/article/6be9eec96c154723b8b9088be27743f9
Autor:
Vishnukamal Golla, Charles D. Scales, David Johnson, Alan L. Kaplan, CJ Stimson, Mark McClellan, Robert Saunders
Publikováno v:
Urology. 171:1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2f1658c7af41cc1156356bd329b574
https://doi.org/10.1016/j.urology.2022.10.008
https://doi.org/10.1016/j.urology.2022.10.008
Autor:
Sneha Parmar, Samuel J. Gonzalez, Julia M. Heckel, Soumya Mukherjee, Mark McClellan, Duncan J. Clarke, Marnie Johansson, Damien Tank, Athena Geisness, David K. Wood, Melissa K. Gardner
Publikováno v:
Journal of Cell Biology. 222
During mitosis, sister chromatids are stretched apart at their centromeres via their attachment to oppositely oriented kinetochore microtubules. This stretching generates inwardly directed tension across the separated sister centromeres. The cell lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22dd67b4f2f5ae879da2af9df644cc73
https://doi.org/10.1083/jcb.202202085
https://doi.org/10.1083/jcb.202202085
Autor:
Martina Bazzaro, Melissa Gardner, Michael K. Lee, Joyce Meints, Teng Ai, Liqiang Chen, Mihir Shetty, Edith Emmings, Vijayalakshmi Shridhar, Mark McClellan, Courtney Coombes, Qing Yang, Yoshie Iizuka, Ashley Mooneyham
UNC-45A, a highly conserved member of the UCS (UNC45A/CRO1/SHE4P) protein family of cochaperones, plays an important role in regulating cytoskeletal-associated functions in invertebrates and mammalian cells, including cytokinesis, exocytosis, cell mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e73f2e83f4f2df708b1ac8317f54bcac
https://doi.org/10.1158/1541-7786.c.6541335
https://doi.org/10.1158/1541-7786.c.6541335
