Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mark McPate"'
Autor:
Andrew T Miller, Carol Dahlberg, Mark L Sandberg, Ben G Wen, Daniel R Beisner, John A H Hoerter, Albert Parker, Christian Schmedt, Monique Stinson, Jacqueline Avis, Cynthia Cienfuegos, Mark McPate, Pamela Tranter, Martin Gosling, Paul J Groot-Kormelink, Janet Dawson, Shifeng Pan, Shin-Shay Tian, H Martin Seidel, Michael P Cooke
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131071 (2015)
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of the negative regulatory inosi
Externí odkaz:
https://doaj.org/article/60911ac9821349a2a5779985bf95458d
Autor:
Cheryl Carson, Pichai Raman, Jennifer Tullai, Lei Xu, Martin Henault, Emily Thomas, Sarita Yeola, Jianmin Lao, Mark McPate, J Martin Verkuyl, George Marsh, Jason Sarber, Adam Amaral, Scott Bailey, Danuta Lubicka, Helen Pham, Nicolette Miranda, Jian Ding, Hai-Ming Tang, Haisong Ju, Pamela Tranter, Nan Ji, Philipp Krastel, Rishi K Jain, Andrew M Schumacher, Joseph J Loureiro, Elizabeth George, Giuliano Berellini, Nathan T Ross, Simon M Bushell, Gül Erdemli, Jonathan M Solomon
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127498 (2015)
Englerin A is a structurally unique natural product reported to selectively inhibit growth of renal cell carcinoma cell lines. A large scale phenotypic cell profiling experiment (CLiP) of englerin A on ¬over 500 well characterized cancer cell lines
Externí odkaz:
https://doaj.org/article/3ef63ce23a0f45a2b040999806a93624
Autor:
J. Martin Verkuyl, Gurdip Bhalay, Paul J. Groot-Kormelink, Sian Fairbrother, Michiel T. van Diepen, Rebecca Lane, Mark McPate, Martin Gosling, Martin Beckett, Pamela Tranter, Toby C. Kent
Publikováno v:
ASSAY and Drug Development Technologies. 12:282-292
The canonical transient receptor potential channel subfamily (TRPC3, TRPC6, and TRPC7) contains Ca2+ permeable non-selective cation channels that are widely expressed in a variety of tissues. There is increasing evidence implicating TRPC channels, pa
Regulations for cell line development are increasingly more stringent. Providing evidence that a cell line is derived from a single cell is a crucial factor in cell line generation. Typically limited dilution or fluorescence activated cell sorting is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e5f5da619ee7366615cad71981e3df
Autor:
Jian Ding, Martin Henault, Nicolette Miranda, Nathan T. Ross, Scott Bailey, Rishi K. Jain, Hai-Ming Tang, Lei Xu, Danuta Lubicka, Jonathan M Solomon, Jason Sarber, Mark McPate, Helen Trinh Pham, J. Martin Verkuyl, Bushell Simon, Haisong Ju, Adam Amaral, Gul Erdemli, Jennifer Tullai, Andrew M. Schumacher, Pichai Raman, Pamela Tranter, Jianmin Lao, Giuliano Berellini, Elizabeth George, Sarita Yeola, Philipp Krastel, Joseph Loureiro, Emily Thomas, George Marsh, Cheryl Carson, Nan Ji
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127498 (2015)
PLoS ONE
PLoS ONE
Englerin A is a structurally unique natural product reported to selectively inhibit growth of renal cell carcinoma cell lines. A large scale phenotypic cell profiling experiment (CLiP) of englerin A on ¬over 500 well characterized cancer cell lines
Autor:
Jacqueline Avis, Janet Dawson, Paul J. Groot-Kormelink, Albert E. Parker, Shifeng Pan, Mark L. Sandberg, Ben G. Wen, Andrew T. Miller, Cynthia Cienfuegos, H. Martin Seidel, Monique Stinson, Daniel R. Beisner, John A. H. Hoerter, Michael P. Cooke, Shin-Shay Tian, Pamela Tranter, Martin Gosling, Christian Schmedt, Mark McPate, Carol Dahlberg
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0131071 (2015)
PLoS ONE, Vol 10, Iss 6, p e0131071 (2015)
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of the negative regulatory inosi
Autor:
Mark McPate, J. Martin Verkuyl, Toby C. Kent, Martin Gosling, Gurdip Bhalay, Michiel T. van Diepen, Paul J. Groot-Kormelink, Pamela Tranter, Sian Fairbrother, Rebecca Lane
Publikováno v:
Biophysical Journal. 106:753a
TRPC3, TRPC6 and TRPC7 are Ca2+ permeable non-selective cation channels that have been implicated in cancer, cardiovascular, respiratory and kidney diseases. In this study, CHO-K1 cells stably expressing human M3 muscarinic acetylcholine receptors we
Publikováno v:
Biophysical Journal. 98:340a
The introduction of high throughput planar automated electrophysiology systems has brought the potential of ion channels as targets for pharmacological modulation to the forefront. Sophion Biosciences QPatch systems are fully automated electrophysiol