Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mark McHugh"'
Autor:
Sudhanva S. Kashyap, Saurabh Verma, Mark McHugh, Mengisteab Wolday, Paul D. Williams, Alan P. Robertson, Richard J. Martin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Homeostatic plasticity refers to the capacity of excitable cells to regulate their activity to make compensatory adjustments to long-lasting stimulation. It is found across the spectrum of vertebrate and invertebrate species and is driven by
Externí odkaz:
https://doaj.org/article/71dc7ab49cf84c24bf93c846c440a3b3
Autor:
Mark McHugh, Paul Williams, Saurabh Verma, Jo Anne Powell-Coffman, Alan P. Robertson, Richard J. Martin
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss , Pp 38-50 (2020)
Cholinergic agonists, like levamisole, are a major class of anthelmintic drugs that are known to act selectively on nicotinic acetylcholine receptors (nAChRs) on the somatic muscle and nerves of nematode parasites to produce their contraction and spa
Externí odkaz:
https://doaj.org/article/5ea9e1998de04b649d6254f83f2cfece
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 44-53 (2016)
The essential phosphobase methylation pathway for synthesis of phosphocholine is unique to nematodes, protozoa and plants, and thus an attractive antiparasitic molecular target. Herein, we screened compounds from the National Cancer Institute (Develo
Externí odkaz:
https://doaj.org/article/b34b229382d44b3d980fc29598a8903c
Autor:
Marisa Mariani, Shiquan He, Mark McHugh, Mirko Andreoli, Deep Pandya, Steven Sieber, Zheyang Wu, Paul Fiedler, Shohreh Shahabi, Cristiano Ferlini
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101065 (2014)
CRC cancer is one of the deadliest diseases in Western countries. In order to develop prognostic biomarkers for CRC (colorectal cancer) aggressiveness, we analyzed retrospectively 267 CRC patients via a novel, multidimensional biomarker platform. Usi
Externí odkaz:
https://doaj.org/article/f865e35ebaa54640a1fe11e41559304a
Autor:
Deep Pandya, Marisa Mariani, Mark McHugh, Mirko Andreoli, Steven Sieber, Shiquan He, Candice Dowell-Martino, Paul Fiedler, Giovanni Scambia, Cristiano Ferlini
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114750 (2014)
Serous ovarian cancer (SEOC) is the deadliest gynecologic malignancy. MicroRNAs (miRNAs) are a class of small noncoding RNAs which regulate gene expression and protein translation. MiRNAs are also encoded by viruses with the intent of regulating thei
Externí odkaz:
https://doaj.org/article/be347c9d84624122ac2cd1a8067f62bd
Autor:
Peng, Sun, Christina S, Bartlett, Chao, Zheng, Tammy, Bigwarfe, Joshuaine M, Grant, Margit, MacDougall, Valentina, Berger, Steven, Kerr, Hu Sheng, Qian, Mark, McHugh, Hongxing, Chen, Xiaomei, Zhang, Miranda L, Carpenter, Heather N, Robinson, John, Miglietta, Thorsten, Lamla, Ryan M, Fryer
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 382:266-276
Diabetic nephropathy is a leading cause of end-stage renal disease, characterized by endothelial dysfunction and a compromised glomerular permeability barrier. Dysregulation of the angiopoietin 1 (ANGPT1)/angiopoietin 2 (ANGPT2) signaling axis is imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374bd8d82a45deba15901277988434a3
https://doi.org/10.1124/jpet.121.001067
https://doi.org/10.1124/jpet.121.001067
Autor:
Richard J. Martin, Saurabh Verma, Paul D E Williams, Alan P. Robertson, Sudhanva S. Kashyap, Mark McHugh, Mengisteab Wolday
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Homeostatic plasticity refers to the capacity of excitable cells to regulate their activity to make compensatory adjustments to long-lasting stimulation. It is found across the spectrum of vertebrate and invertebrate species and is driven by changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb7989ee16198a15c8ca07330b94095
https://doi.org/10.1038/s41598-021-93911-4
https://doi.org/10.1038/s41598-021-93911-4
Autor:
Sheritta Cooks-Fagbodun, Daniel A. Abugri, William H. Witola, Kwame Matthews, Adriana Reyes Ordonez, Mark McHugh
Publikováno v:
Veterinary Parasitology. 223:1-6
The phosphobase methylation pathway, in which phosphoethanolamine N-methyltransferases (PMTs) successively catalyze the methylation of phosphoethanolamine to phosphocholine, is essential in the free-living nematode Caenorhabditis elegans. Two PMT-enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9d1be7851e80d541cce5c31b8d02cc
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 44-53 (2016)
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 44-53 (2016)
The essential phosphobase methylation pathway for synthesis of phosphocholine is unique to nematodes, protozoa and plants, and thus an attractive antiparasitic molecular target. Herein, we screened compounds from the National Cancer Institute (Develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4072603f2a48617ba0b0ce2ee381eb94
https://doi.org/10.1016/j.ijpddr.2016.01.002
https://doi.org/10.1016/j.ijpddr.2016.01.002
Publikováno v:
Parasitology International. 63:651-658
Toxoplasma gondii dense granule proteins (GRAs) are secreted abundantly in both the tachyzoite and bradyzoite stages of the parasite and are known to localize to various compartments of the parasitophorous vacuole (PV) that interfaces with the host c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd53800f16bb215e9bb062b75ef03f4
https://doi.org/10.1016/j.parint.2014.05.001
https://doi.org/10.1016/j.parint.2014.05.001