Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Mark Mapstone"'
Autor:
Patrick Lao, Natalie Edwards, Lisi Flores-Aguilar, Mohamad Alshikho, Batool Rizvi, Dana Tudorascu, H. Diana Rosas, Michael Yassa, Bradley T. Christian, Mark Mapstone, Benjamin Handen, Molly E. Zimmerman, Jose Gutierrez, Donna Wilcock, Elizabeth Head, Adam M. Brickman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Adults with Down syndrome have a genetic form of Alzheimer’s disease (AD) and evidence of cerebrovascular disease across the AD continuum, despite few systemic vascular risk factors. The onset and progression of AD in Down syndrome is high
Externí odkaz:
https://doaj.org/article/4a432bd6f9aa4c0fbc74fe1536e6faa9
Autor:
Laura Xicota, Lam-Ha T. Dang, Alice Lee, Sharon Krinsky-McHale, Deborah Pang, Lisa Melilli, Sid O'Bryant, Rachel L. Henson, Charles Laymon, Florence Lai, H. Diana Rosas, Beau Ances, Ira Lott, Christy Hom, Bradley Christian, Sigan Hartley, Shahid Zaman, Elizabeth Head, Mark Mapstone, Zhezhen Jin, Wayne Silverman, Nicole Schupf, Benjamin Handen, Joseph H. Lee, Howard J. Aizenstein, Beau M. Ances, Howard F. Andrews, Karen Bell, Rasmus Birn, Adam M. Brickman, Peter Bulova, Amrita Cheema, Kewei Chen, Bradley T. Christian, Isabel Clare, Lorraine Clark, Ann D. Cohen, John N. Constantino, Eric W. Doran, Anne Fagan, Eleanor Feingold, Tatiana M. Foroud, Benjamin L. Handen, Jordan Harp, Sigan L. Hartley, Rachel Henson, Lawrence Honig, Milos D. Ikonomovic, Sterling C. Johnson, Courtney Jordan, M.Ilyas Kamboh, David Keator, William E. Klunk, Julia K. Kofler, William Charles Kreisl, Sharon J. Krinsky-McHale, Patrick Lao, Ira T. Lott, Victoria Lupson, Chester A. Mathis, Davneet Singh Minhas, Neelesh Nadkarni, Sid O’Bryant, Melisa Parisi, Melissa Pettersen, Julie C. Price, Margaret Pulsifer, Michael S. Rafii, Eric Reiman, Batool Rizvi, Laurie Ryan, Frederick Schmitt, Wayne P. Silverman, Dana L. Tudorascu, Rameshwari Tumuluru, Benjamin Tycko, Badri Varadarajan, Desiree A. White, Michael A. Yassa, Fan Zhang
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105433- (2024)
Summary: Background: Individuals with Down syndrome (DS) are at high risk of early-onset Alzheimer's disease (AD); yet, some 20 percent do not develop any signs of dementia until after 65 years or in their lifetime. Mosaicism could contribute to this
Externí odkaz:
https://doaj.org/article/7bcbc45f9a5e40b7ab0502504ef1c084
Autor:
Emily K. Schworer, Benjamin L. Handen, Melissa Petersen, Sid O'Bryant, Jamie C. Peven, Dana L. Tudorascu, Laisze Lee, Sharon J. Krinsky‐McHale, Christy L. Hom, Isabel C. H. Clare, Bradley T. Christian, Nicole Schupf, Joseph H. Lee, Elizabeth Head, Mark Mapstone, Ira Lott, Beau M. Ances, Shahid Zaman, Adam M. Brickman, Florence Lai, H. Diana Rosas, Sigan L. Hartley, the Alzheimer Biomarker Consortium‐Down Syndrome
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION People with Down syndrome (DS) have a 75% to 90% lifetime risk of Alzheimer's disease (AD). AD pathology begins a decade or more prior to onset of clinical AD dementia in people with DS. It is not clear if plasma biomarkers of A
Externí odkaz:
https://doaj.org/article/13dbf3a21419485bb2909612d2c5af23
Autor:
Natalie DiProspero, Mithra Sathishkumar, John Janecek, Anna Smith, Liv McMillan, Melissa Petersen, Nicholas Tustison, David B. Keator, Eric Doran, Christy L. Hom, Dana Nguyen, Howard Andrews, Sharon Krinsky‐McHale, Adam M. Brickman, H. Diana Rosas, Florence Lai, Elizabeth Head, Mark Mapstone, Wayne Silverman, Ira T. Lott, Sid O'Bryant, Michael A. Yassa
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION Virtually all people with Down syndrome (DS) develop neuropathology associated with Alzheimer's disease (AD). Atrophy of the hippocampus and entorhinal cortex (EC), as well as elevated plasma concentrations of neurofilament ligh
Externí odkaz:
https://doaj.org/article/7422d877af6a4072bb0972d4b84616f7
Autor:
Sage J. B. Dunham, Katelyn A. McNair, Eric D. Adams, Julio Avelar-Barragan, Stefania Forner, Mark Mapstone, Katrine L. Whiteson
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Recent reports implicate gut microbiome dysbiosis in the onset and progression of Alzheimer’s disease (AD), yet studies involving model animals overwhelmingly omit the microbial perspective. Here, we evaluate longitudinal microbiomes and m
Externí odkaz:
https://doaj.org/article/98b65b590d3541b9a05941e33dbbd17b
Autor:
Quanjing Chen, Timothy M. Baran, Brian Rooks, M. Kerry O'Banion, Mark Mapstone, Zhengwu Zhang, Feng Lin
Publikováno v:
NeuroImage: Clinical, Vol 28, Iss , Pp 102413- (2020)
Studying older adults with excellent cognitive capacities (Supernormals) provides a unique opportunity for identifying factors related to cognitive success – a critical topic across lifespan. There is a limited understanding of Supernormals’ neur
Externí odkaz:
https://doaj.org/article/a36925ed4bee4f01bcedd540edd0b5f6
Autor:
Michael S. Rafii, Beau M. Ances, Nicole Schupf, Sharon J. Krinsky‐McHale, Mark Mapstone, Wayne Silverman, Ira Lott, William Klunk, Elizabeth Head, Brad Christian, Florence Lai, H. Diana Rosas, Shahid Zaman, Melissa E. Petersen, Andre Strydom, Juan Fortea, Benjamin Handen, Sid O'Bryant
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract The National Institute on Aging in conjunction with the Alzheimer's Association (NIA‐AA) recently proposed a biological framework for defining the Alzheimer's disease (AD) continuum. This new framework is based upon the key AD biomarkers (
Externí odkaz:
https://doaj.org/article/26343955218246fdbf706ffb828d3c44
Autor:
Melissa E. Petersen, Fan Zhang, Nicole Schupf, Sharon J. Krinsky‐McHale, James Hall, Mark Mapstone, Amrita Cheema, Wayne Silverman, Ira Lott, Michael S. Rafii, Benjamin Handen, William Klunk, Elizabeth Head, Brad Christian, Tatiana Foroud, Florence Lai, H. Diana Rosas, Shahid Zaman, Beau M. Ances, Mei‐Cheng Wang, Benjamin Tycko, Joseph H. Lee, Sid O'Bryant, the Alzheimer's Biomarker Consortium – Down Syndrome (ABC‐DS)
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI‐DS) and Alzheimer's d
Externí odkaz:
https://doaj.org/article/6198ea4b42bc4c93a83dd033c6ae686d
Autor:
Mark Mapstone, Thomas J Gross, Fabio Macciardi, Amrita K Cheema, Melissa Petersen, Elizabeth Head, Benjamin L Handen, William E Klunk, Bradley T Christian, Wayne Silverman, Ira T Lott, Nicole Schupf, for the Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Disruption of metabolic function is a recognized feature of late onset Alzheimer's disease (LOAD). We sought to determine whether similar metabolic pathways are implicated in adults with Down syndrome (DS) who have increased ris
Externí odkaz:
https://doaj.org/article/f84990f465ff493aa63689665c43d389
Autor:
Benjamin L. Handen, Ira T. Lott, Bradley T. Christian, Nicole Schupf, Sid OBryant, Mark Mapstone, Anne M. Fagan, Joseph H. Lee, Dana Tudorascu, Mei‐Cheng Wang, Elizabeth Head, William Klunk, Beau Ances, Florence Lai, Shahid Zaman, Sharon Krinsky‐McHale, Adam M. Brickman, H. Diana Rosas, Annie Cohen, Howard Andrews, Sigan Hartley, Wayne Silverman, the Alzheimer's Biomarker Consortium‐Down Syndrome (ABC‐DS)
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Adults with Down syndrome (DS) are at exceptionally high risk for Alzheimer's disease (AD), with virtually all individuals developing key neuropathological features by age 40. Identifying biomarkers of AD progression in DS can p
Externí odkaz:
https://doaj.org/article/df7df8f8d193416b869df1e178f0691b