Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mark Mackiewicz"'
Autor:
Brianne B. Rogers, Ashlyn G. Anderson, Shelby N. Lauzon, M. Natalie Davis, Rebecca M. Hauser, Sydney C. Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A. Barinaga, Jared W. Taylor, Mark Mackiewicz, Brian S. Roberts, Sara J. Cooper, Lindsay F. Rizzardi, Richard M. Myers, J. Nicholas Cochran
BackgroundTauopathies are a group of neurodegenerative diseases driven by abnormal aggregates of tau, a microtubule associated protein encoded by theMAPTgene.MAPTexpression is absent in neural progenitor cells (NPCs) and increases during differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b669916991844fab28b170d29302d08c
https://doi.org/10.1101/2023.03.07.531520
https://doi.org/10.1101/2023.03.07.531520
Autor:
Joel Rozowsky, Jiahao Gao, Beatrice Borsari, Yucheng T. Yang, Timur Galeev, Gamze Gürsoy, Charles B. Epstein, Kun Xiong, Jinrui Xu, Tianxiao Li, Jason Liu, Keyang Yu, Ana Berthel, Zhanlin Chen, Fabio Navarro, Maxwell S. Sun, James Wright, Justin Chang, Christopher J.F. Cameron, Noam Shoresh, Elizabeth Gaskell, Jorg Drenkow, Jessika Adrian, Sergey Aganezov, François Aguet, Gabriela Balderrama-Gutierrez, Samridhi Banskota, Guillermo Barreto Corona, Sora Chee, Surya B. Chhetri, Gabriel Conte Cortez Martins, Cassidy Danyko, Carrie A. Davis, Daniel Farid, Nina P. Farrell, Idan Gabdank, Yoel Gofin, David U. Gorkin, Mengting Gu, Vivian Hecht, Benjamin C. Hitz, Robbyn Issner, Yunzhe Jiang, Melanie Kirsche, Xiangmeng Kong, Bonita R. Lam, Shantao Li, Bian Li, Xiqi Li, Khine Zin Lin, Ruibang Luo, Mark Mackiewicz, Ran Meng, Jill E. Moore, Jonathan Mudge, Nicholas Nelson, Chad Nusbaum, Ioann Popov, Henry E. Pratt, Yunjiang Qiu, Srividya Ramakrishnan, Joe Raymond, Leonidas Salichos, Alexandra Scavelli, Jacob M. Schreiber, Fritz J. Sedlazeck, Lei Hoon See, Rachel M. Sherman, Xu Shi, Minyi Shi, Cricket Alicia Sloan, J Seth Strattan, Zhen Tan, Forrest Y. Tanaka, Anna Vlasova, Jun Wang, Jonathan Werner, Brian Williams, Min Xu, Chengfei Yan, Lu Yu, Christopher Zaleski, Jing Zhang, Kristin Ardlie, J Michael Cherry, Eric M. Mendenhall, William S. Noble, Zhiping Weng, Morgan E. Levine, Alexander Dobin, Barbara Wold, Ali Mortazavi, Bing Ren, Jesse Gillis, Richard M. Myers, Michael P. Snyder, Jyoti Choudhary, Aleksandar Milosavljevic, Michael C. Schatz, Bradley E. Bernstein, Roderic Guigó, Thomas R. Gingeras, Mark Gerstein
Understanding how genetic variants impact molecular phenotypes is a key goal of functional genomics, currently hindered by reliance on a single haploid reference genome. Here, we present the EN-TEx resource of 1,635 open-access datasets from four don
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464939170ba93b49ee4e474d325702f1
http://hdl.handle.net/10230/56942
http://hdl.handle.net/10230/56942
Autor:
Barbara J. Wold, Laurel A. Brandsmeier, Jeremy W. Prokop, Richard M. Myers, Shan Jiang, Mark Mackiewicz, Sarah Meadows, Ali Mortazavi, Camden Jansen, Eric M. Mendenhall, Daniel Savic, Ryne C. Ramaker, Candice J. Coppola, Andrew A. Hardigan, Surya B. Chhetri, Emma C. Dean, E. Christopher Partridge, Kimberly M. Newberry, C. Luke Messer, Say-Tar Goh
Publikováno v:
Nature
Transcription factors are DNA-binding proteins that have key roles in gene regulation1,2. Genome-wide occupancy maps of transcriptional regulators are important for understanding gene regulation and its effects on diverse biological processes3–6. H
Autor:
Joel Rozowsky, Jorg Drenkow, Yucheng T Yang, Gamze Gursoy, Timur Galeev, Beatrice Borsari, Charles B Epstein, Kun Xiong, Jinrui Xu, Jiahao Gao, Keyang Yu, Ana Berthel, Zhanlin Chen, Fabio Navarro, Jason Liu, Maxwell S Sun, James Wright, Justin Chang, Christopher JF Cameron, Noam Shoresh, Elizabeth Gaskell, Jessika Adrian, Sergey Aganezov, François Aguet, Gabriela Balderrama-Gutierrez, Samridhi Banskota, Guillermo Barreto Corona, Sora Chee, Surya B Chhetri, Gabriel Conte Cortez Martins, Cassidy Danyko, Carrie A Davis, Daniel Farid, Nina P Farrell, Idan Gabdank, Yoel Gofin, David U Gorkin, Mengting Gu, Vivian Hecht, Benjamin C Hitz, Robbyn Issner, Melanie Kirsche, Xiangmeng Kong, Bonita R Lam, Shantao Li, Bian Li, Tianxiao Li, Xiqi Li, Khine Zin Lin, Ruibang Luo, Mark Mackiewicz, Jill E Moore, Jonathan Mudge, Nicholas Nelson, Chad Nusbaum, Ioann Popov, Henry E Pratt, Yunjiang Qiu, Srividya Ramakrishnan, Joe Raymond, Leonidas Salichos, Alexandra Scavelli, Jacob M Schreiber, Fritz J Sedlazeck, Lei Hoon See, Rachel M Sherman, Xu Shi, Minyi Shi, Cricket Alicia Sloan, J Seth Strattan, Zhen Tan, Forrest Y Tanaka, Anna Vlasova, Jun Wang, Jonathan Werner, Brian Williams, Min Xu, Chengfei Yan, Lu Yu, Christopher Zaleski, Jing Zhang, Kristin Ardlie, J Michael Cherry, Eric M Mendenhall, William S Noble, Zhiping Weng, Morgan E Levine, Alexander Dobin, Barbara Wold, Ali Mortazavi, Bing Ren, Jesse Gillis, Richard M Myers, Michael P Snyder, Jyoti Choudhary, Aleksandar Milosavljevic, Michael C Schatz, Roderic Guigó, Bradley E Bernstein, Thomas R Gingeras, Mark Gerstein
Understanding how genetic variants impact molecular phenotypes is a key goal of functional genomics, currently hindered by reliance on a single haploid reference genome. Here, we present the EN-TEx resource of personal epigenomes, for ∼25 tissues a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f293c3be99001dfcca0596fbe318c048
https://doi.org/10.1101/2021.04.26.441442
https://doi.org/10.1101/2021.04.26.441442
Autor:
Carrie A. Davis, Charles B. Epstein, Eric L. Van Nostrand, Valentina Snetkova, Michael J. Purcaro, Manolis Kellis, Yupeng He, Henry Pratt, John A. Stamatoyannopoulos, Ali Mortazavi, Xintao Wei, Michael Snyder, Jialing Zhang, Job Dekker, Anshul Kundaje, Shaimae I. Elhajjajy, Gene W. Yeo, Jessica Halow, Peggy J. Farnham, Kevin P. White, Xiaofeng Wang, Eric M. Mendenhall, Diane E. Dickel, John L. Rinn, Thomas R. Gingeras, Yin Shen, Juan Carlos Rivera-Mulia, David U. Gorkin, William Stafford Noble, Rajinder Kaul, David M. Gilbert, Jill Moore, Xiao-Ou Zhang, Peter Freese, Bing Ren, Joseph R. Ecker, Eric Lécuyer, Christopher B. Burge, Ross C. Hardison, Jing Zhang, Zhiping Weng, Richard M. Myers, Robert J. Klein, Brian A. Williams, Alexander Dobin, Alec Victorsen, Noam Shoresh, Joel Rozowsky, Jack Huey, Bradley E. Bernstein, Mark Mackiewicz, Roderic Guigó, Axel Visel, Brenton R. Graveley, J. Michael Cherry, Trupti Kawli, Mark Gerstein, Cheryl A. Keller, Barbara J. Wold, Jessika Adrian, Len A. Pennacchio, Florencia Pauli-Behn, Surya B. Chhetri
Publikováno v:
Moore, Jill E; Purcaro, Michael J; Pratt, Henry E; Epstein, Charles B; Shoresh, Noam; Adrian, Jessika; Kawli, Trupti; Davis, Carrie A; Dobin, Alexander; Kaul, Rajinder; Halow, Jessica; Van Nostrand, Eric L; Freese, Peter; Gorkin, David U; Shen, Yin; He, Yupeng; Mackiewicz, Mark; Pauli-Behn, Florencia; Williams, Brian A; Mortazavi, Ali; ... (2020). Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature, 583(7818), pp. 699-710. Springer Nature 10.1038/s41586-020-2493-4
Nature
Nature, vol. 583, no. 7818, pp. 699-710
Nature
Nature, vol. 583, no. 7818, pp. 699-710
The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia of DNA Elements (ENCODE) Pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c895e469a429f18f75d20f5b0e64d2e
https://boris.unibe.ch/146110/1/s41586-020-2493-4.pdf
https://boris.unibe.ch/146110/1/s41586-020-2493-4.pdf
Autor:
Sarah K, Meadows, Laurel A, Brandsmeier, Kimberly M, Newberry, Michael J, Betti, Amy S, Nesmith, Mark, Mackiewicz, E Christopher, Partridge, Eric M, Mendenhall, Richard M, Myers
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2117
Chromatin immunoprecipitation followed by next-generation DNA sequencing (ChIP-seq) has been used to identify transcription factor (TF) binding proteins throughout the genome. Unfortunately, this approach traditionally requires commercially available
Autor:
Laurel A. Brandsmeier, Mark Mackiewicz, Amy S. Nesmith, Eric M. Mendenhall, Richard M. Myers, Sarah Meadows, Michael J Betti, Kimberly M. Newberry, E. Christopher Partridge
Publikováno v:
Methods in Molecular Biology ISBN: 9781071603000
Chromatin immunoprecipitation followed by next-generation DNA sequencing (ChIP-seq) has been used to identify transcription factor (TF) binding proteins throughout the genome. Unfortunately, this approach traditionally requires commercially available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::384c984eb0a3c9a205c14ac264c72f70
https://doi.org/10.1007/978-1-0716-0301-7_1
https://doi.org/10.1007/978-1-0716-0301-7_1
Autor:
Ali Mortazavi, Brian Williams, Mark Mackiewicz, Weihua Zeng, Alexander Dobin, Brian S. Roberts, Carrie A. Davis, Dianna E. Moore, Rabi Murad, Alessandra Breschi, Chris Zaleski, Alex Scavelli, Thomas R. Gingeras, Sorena Rahmanian, Lei-Hoon Sei, Sarah Meadows, Diane Trout, Roderic Guigó, Richard M. Myers, Jorg Drenkow, Barbara J. Wold
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
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MicroRNAs (miRNAs) play a critical role as post-transcriptional regulators of gene expression. The ENCODE project profiled the expression of miRNAs in a comprehensive set of tissues during a time-course of mouse embryonic development and captured the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b1374845e10f4e08ad8dc0bf428db2
http://hdl.handle.net/10230/43159
http://hdl.handle.net/10230/43159
Publikováno v:
Seminars in Cell & Developmental Biology. 57:40-50
Deciphering the intricate molecular processes that orchestrate the spatial and temporal regulation of genes has become an increasingly major focus of biological research. The differential expression of genes by diverse cell types with a common genome
Autor:
John K. Simmons, Jason J. Pitt, Mark Mackiewicz, Jyoti Dinker Patel, Tamara L. Jones, Sirisha Chakka, Paul K. Goldsmith, Jin-Qiu Chen, Wendy Dubois, Konrad Huppi, Natasha J. Caplen, Scott E. Martin, Kristen Gehlhaus, Beverly A. Mock, Oliver Ou
Publikováno v:
Cancer Letters. 354:336-347
The use of molecularly targeted drugs as single agents has shown limited utility in many tumor types, largely due to the complex and redundant nature of oncogenic signaling networks. Targeting of the PI3K/AKT/mTOR pathway through inhibition of mTOR i