Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Mark M. Rich"'
Autor:
Stephen N. Housley, Evelyn A. Gardolinski, Paul Nardelli, J'Ana Reed, Mark M. Rich, Timothy C. Cope
Publikováno v:
Experimental Physiology, Vol 109, Iss 1, Pp 35-44 (2024)
Abstract Our objective was to evaluate an ex vivo muscle–nerve preparation used to study mechanosensory signalling by low threshold mechanosensory receptors (LTMRs). Specifically, we aimed to assess how well the ex vivo preparation represents in vi
Externí odkaz:
https://doaj.org/article/7158e4025d6244deae5912a21c1f04fa
Autor:
Daniel J. Ham, Anastasiya Börsch, Shuo Lin, Marco Thürkauf, Martin Weihrauch, Judith R. Reinhard, Julien Delezie, Fabienne Battilana, Xueyong Wang, Marco S. Kaiser, Maitea Guridi, Michael Sinnreich, Mark M. Rich, Nitish Mittal, Lionel A. Tintignac, Christoph Handschin, Mihaela Zavolan, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
mTORC1 expression is increased during ageing of muscle, and on the other hand, its activation promotes muscle hypertrophy. Here, the authors assess whether mTORC1 has positive or negative effects on ageing, and show that its long-term inhibition pres
Externí odkaz:
https://doaj.org/article/05a591c692df4b149c92e816d5905072
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101182- (2021)
Huntington's disease (HD) causes neurological impairments, as well as muscle dysfunction, including smaller neuromuscular junctions (NMJs). This study assessed the expression levels of the subunits of the nicotinic acetylcholine receptor (nAChR) in m
Externí odkaz:
https://doaj.org/article/496216020d6f4e1f96f433d850e60e4e
Autor:
Jacob A. Vincent, Krystyna B. Wieczerzak, Hanna M. Gabriel, Paul Nardelli, Mark M. Rich, Timothy C. Cope
Publikováno v:
Neurobiology of Disease, Vol 95, Iss , Pp 54-65 (2016)
Persistent neurotoxic side effects of oxaliplatin (OX) chemotherapy, including sensory ataxia, limit the efficacy of treatment and significantly diminish patient quality of life. The common explanation for neurotoxicity is neuropathy, however the deg
Externí odkaz:
https://doaj.org/article/09fb9bc0271c4929a0d6dfed8fa2f0ec
Autor:
Jacob A. Vincent, Krystyna B. Wieczerzak, Hanna M. Gabriel, Paul Nardelli, Mark M. Rich, Timothy C. Cope
Publikováno v:
Neurobiology of Disease, Vol 98, Iss , Pp 158- (2017)
Externí odkaz:
https://doaj.org/article/9c2dd1cec01d4affa1ae6cc61737ea00
Autor:
Dario I. Carrasco, Edyta K. Bichler, Mark M. Rich, Xueyong Wang, Kevin L. Seburn, Martin J. Pinter
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 1, Pp 132-140 (2012)
This study examined whether activity is a contributing factor to motor terminal degeneration in mice that overexpress the G93A mutation of the SOD1 enzyme found in humans with inherited motor neuron disease. Previously, we showed that overload of mus
Externí odkaz:
https://doaj.org/article/f51b2d5e87d749ceb175a3aabaf2f8a4
Publikováno v:
Neurobiology of Disease, Vol 6, Iss 6, Pp 515-522 (1999)
In rats treated with high-dose corticosteroids, skeletal muscle that is denervated in vivo (steroid-denervated) develops electrical inexcitability similar to that seen in patients with acute quadriplegic myopathy. To determine whether changes in musc
Externí odkaz:
https://doaj.org/article/61a4e54d0bb144058f2b59a46d3b7a9d
Autor:
Xueyong Wang, Murad Nawaz, Chris DuPont, Jessica H Myers, Steve RA Burke, Roger A Bannister, Brent D Foy, Andrew A Voss, Mark M Rich
Publikováno v:
eLife, Vol 11 (2022)
Excitation-contraction coupling (ECC) is the process by which electrical excitation of muscle is converted into force generation. Depolarization of skeletal muscle resting potential contributes to failure of ECC in diseases such as periodic paralysis
Externí odkaz:
https://doaj.org/article/ccd1295cc8eb45478225599c31db8d5d
Autor:
Jessica H Myers, Kirsten Denman, Chris DuPont, Ahmed A Hawash, Kevin R Novak, Andrew Koesters, Manfred Grabner, Anamika Dayal, Andrew A Voss, Mark M Rich
Publikováno v:
eLife, Vol 10 (2021)
In addition to the hallmark muscle stiffness, patients with recessive myotonia congenita (Becker disease) experience debilitating bouts of transient weakness that remain poorly understood despite years of study. We performed intracellular recordings
Externí odkaz:
https://doaj.org/article/f201e13c4e5f4c20b08b45b730d90c95
Autor:
Stephen N. Housley, Evelyn A. Gardolinski, Paul Nardelli, J'Ana Reed, Mark M. Rich, Timothy C. Cope
Publikováno v:
Experimental Physiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01b3bcaafee576e38b5ba252b7281a54
https://doi.org/10.1113/ep090763
https://doi.org/10.1113/ep090763