Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Mark M. Emerson"'
Autor:
Xueqing Chen, Mark M. Emerson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Notch signaling is required to repress the formation of vertebrate cone photoreceptors and to maintain the proliferative potential of multipotent retinal progenitor cells. However, the mechanism by which Notch signaling controls these proces
Externí odkaz:
https://doaj.org/article/7619a49ad38c47f59e5abf5ba2cd289d
Autor:
Sruti Patoori, Nathalie Jean-Charles, Ariana Gopal, Sacha Sulaiman, Sneha Gopal, Brian Wang, Benjamin Souferi, Mark M. Emerson
Publikováno v:
Neural Development, Vol 15, Iss 1, Pp 1-20 (2020)
Abstract Background The vertebrate retina consists of six major classes of neuronal cells. During development, these cells are generated from a pool of multipotent retinal progenitor cells (RPCs) that express the gene Vsx2. Fate-restricted RPCs have
Externí odkaz:
https://doaj.org/article/18f17136c4384073a053d8807c90714a
Publikováno v:
Neural Development, Vol 13, Iss 1, Pp 1-20 (2018)
Abstract Background Cone and rod photoreceptors are two of the primary cell types affected in human retinal disease. Potential strategies to combat these diseases are the use of gene therapy to rescue compromised photoreceptors or to generate new fun
Externí odkaz:
https://doaj.org/article/a262dbd36fc245f49b2243abd0d8bd15
Autor:
Benjamin Souferi, Mark M. Emerson
Publikováno v:
Biology Open, Vol 8, Iss 4 (2019)
Enhancer activity is determined by both the activity and occupancy of transcription factors as well as the specific sequences they bind. Experimental investigation of this dynamic requires the ability to manipulate components of the system, ideally i
Externí odkaz:
https://doaj.org/article/ca9fb90b9f8141fe9057f4ac5c9bde87
Autor:
Mark M. Emerson, Xueqing Chen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports
Scientific Reports
Notch signaling is required to repress the formation of vertebrate cone photoreceptors and to maintain the proliferative potential of multipotent retinal progenitor cells. However, the mechanism by which Notch signaling controls these processes is un
Autor:
Cheng-Hui Lin, Yue Sun, Candace S.Y. Chan, Man-Ru Wu, Lei Gu, Alexander E. Davis, Baokun Gu, Wenlin Zhang, Bogdan Tanasa, Lei R. Zhong, Mark M. Emerson, Lu Chen, Jun B. Ding, Sui Wang
Publikováno v:
The Journal of biological chemistry. 298(4)
Adeno-associated viruses (AAVs) targeting specific cell types are powerful tools for studying distinct cell types in the central nervous system (CNS). Cis-regulatory modules (CRMs), e.g., enhancers, are highly cell-type-specific and can be integrated
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The early transcriptional events that occur in newly generated cone photoreceptors are not well described. Knowledge of these events is critical to provide benchmarks for in vitro-derived cone photoreceptors and to understand the process of c
Autor:
Lei R. Zhong, Alexander E. Davis, Mark M. Emerson, Cheng Hui Lin, Bogdan Tanasa, Yue Sun, Candace S.Y. Chan, Lu Chen, Man Ru Wu, Lei Gu, Jun B. Ding, Sui Wang
Publikováno v:
SSRN Electronic Journal.
Adeno Associated Viruses (AAVs) targeting specific cell types are powerful tools for studying distinct cell types in the central nervous system (CNS). Cis-regulatory modules (CRMs), e.g., enhancers, are highly cell type-specific and can be integrated
Autor:
Mark M. Emerson, Miruna Georgiana Ghinia Tegla, Estie Schick, Kazi Hossain, Kevin C. Gonzalez, Pooja Dutta
Publikováno v:
Dev Biol
During retinal development, multipotent and restricted progenitor cells generate all of the neuronal cells of the retina. Among these are horizontal cells, which are interneurons that modulate the light-induced signal from photoreceptors. This study
Autor:
Miruna Georgiana Ghinia Tegla, Mark M. Emerson, Kevin C. Gonzalez, Cassandra Thakurdin, Diego F. Buenaventura, Diana Y Kim
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
During vertebrate retinal development, subsets of progenitor cells generate progeny in a non-stochastic manner, suggesting that these decisions are tightly regulated. However, the gene-regulatory network components that are functionally important in