Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Mark M Mutawe"'
Autor:
Saeid Ghavami, Mark M Mutawe, Pawan Sharma, Behzad Yeganeh, Karol D McNeill, Thomas Klonisch, Helmut Unruh, Hessam H Kashani, Dedmer Schaafsma, Marek Los, Andrew J Halayko
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16523 (2011)
Statins inhibit the proximal steps of cholesterol biosynthesis, and are linked to health benefits in various conditions, including cancer and lung disease. We have previously investigated apoptotic pathways triggered by statins in airway mesenchymal
Externí odkaz:
https://doaj.org/article/355b8c38925742648fe47238996f5963
Autor:
Andrew J. Halayko, Hessam H. Kashani, Mark M. Mutawe, Aruni Jha, Pawan K. Sharma, Thomas Klonisch, Behzad Yeganeh, Oluwaseun O. Ojo, Helmut Unruh, Saeid Ghavami, Marek Los
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1843:1259-1271
HMG-CoA reductase, the proximal rate-limiting enzyme in the mevalonate pathway, is inhibited by statins. Beyond their cholesterol lowering impact, statins have pleiotropic effects and their use is linked to improved lung health. We have shown that me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d0e992e433d2370da72d71f2addd6c
https://doi.org/10.1016/j.bbamcr.2014.03.006
https://doi.org/10.1016/j.bbamcr.2014.03.006
Autor:
Mark M. Mutawe, Richard W. Mitchell, Behzad Yeganeh, Min Hyung Ryu, Pawan K. Sharma, Sarah A. Maltby, Sujata Basu, Andrew J. Halayko
Publikováno v:
British Journal of Pharmacology. 167:548-560
Background And Purpose Acute silencing of caveolin-1 (Cav-1) modulates receptor-mediated contraction of airway smooth muscle. Moreover, COX-2- and 5-lipoxygenase (5-LO)-derived prostaglandin and leukotriene biosynthesis can influence smooth muscle re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7be48cd3852ad184ccf7b5b74dc844
https://doi.org/10.1111/j.1476-5381.2012.02014.x
https://doi.org/10.1111/j.1476-5381.2012.02014.x
Autor:
Mark M. Mutawe, Andrew J. Halayko, Thomas Klonisch, Saeid Ghavami, Behzad Yeganeh, Dedmer Schaafsma, Helmut Unruh
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 302:L420-L428
Geranylgeranyl transferase 1 (GGT1) is involved in the posttranslational prenylation of signaling proteins, such as small GTPases. We have shown that blocking the formation of isoprenoids with statins regulates survival of human lung mesenchymal cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd8a867cd2aca8b9c04fe4b6af032c8
https://doi.org/10.1152/ajplung.00312.2011
https://doi.org/10.1152/ajplung.00312.2011
Autor:
Helmut Unruh, Andrew J. Halayko, Sophie Bos, Reinoud Gosens, Mark M. Mutawe, Gordon Dueck, Dedmer Schaafsma, Gerald L. Stelmack, William T. Gerthoffer, Johan Zaagsma, Herman Meurs
Publikováno v:
Journal of cellular and molecular medicine, 15(11), 2430-2442. Wiley
Journal of Cellular and Molecular Medicine
Journal of Cellular and Molecular Medicine
Airway smooth muscle cells exhibit phenotype plasticity that underpins their ability to contribute both to acute bronchospasm and to the features of airway remodelling in chronic asthma. A feature of mature, contractile smooth muscle cells is the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5549b7f459185b9d3dd59793a7fa658b
https://doi.org/10.1111/j.1582-4934.2010.01246.x
https://doi.org/10.1111/j.1582-4934.2010.01246.x
Autor:
Gordon Dueck, Helmut Unruh, Saeid Ghavami, Grant M. Hatch, Andrew J. Halayko, Andrea Kroeker, Dedmer Schaafsma, Karol D. McNeill, Mark M. Mutawe, Kristin Hauff, Fred Y. Xu
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 44:394-403
Smooth muscle cells promote fibroproliferative airway remodeling in asthma, and transforming growth factor β1 (TGFβ1) is a key inductive signal. Statins are widely used to treat hyperlipidemia. Growing evidence indicates they also exert a positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577f1589eabc90a856c13ec2d8e04ad2
https://doi.org/10.1165/rcmb.2010-0052oc
https://doi.org/10.1165/rcmb.2010-0052oc
Autor:
Andrew J. Halayko, Reinoud Gosens, Sophie Bos, Sarah A. Martin, Sujata Basu, Mark M. Mutawe, Thai Tran
Publikováno v:
Current Molecular Medicine. 8:741-753
Caveolae are flask-shaped invaginations of the plasma membrane that are present in most structu- ral cells. They owe their characteristic �-shape to complexes of unique proteins, the caveolins, which indirectly tether cholesterol and sphingolipid-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc85b6303160e2ca9aad8ec6eca8015
https://doi.org/10.2174/156652408786733720
https://doi.org/10.2174/156652408786733720
Autor:
Andrew J. Halayko, Mark M. Mutawe, Gerald L. Stelmack, Karol D. McNeill, Reinoud Gosens, William T. Gerthoffer, Pawan K. Sharma, Thai Tran, Helmut Unruh
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 294(1), L57-L68. AMER PHYSIOLOGICAL SOC
Airway smooth muscle (ASM) cells may contribute to asthma pathogenesis through their capacity to switch between a synthetic/proliferative and a contractile phenotype. The multimeric dystrophin-glycoprotein complex (DGC) spans the sarcolemma, linking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c990e73ce9869ae6d9f302c1e2db69
https://doi.org/10.1152/ajplung.00378.2007
https://doi.org/10.1152/ajplung.00378.2007
Autor:
Reinoud Gosens, Karol D. McNeill, Johan Zaagsma, Angela Paulson, Helmut Unruh, Gerald L. Stelmack, Mark M. Mutawe, Andrew J. Halayko, James A. Thliveris, Shyamala Dakshinamurti, William T. Gerthoffer, Martha Hinton, Gordon Dueck
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 293(6), L1406-L1418. AMER PHYSIOLOGICAL SOC
Contractile responses of airway smooth muscle (ASM) determine airway resistance in health and disease. Caveolae microdomains in the plasma membrane are marked by caveolin proteins and are abundant in contractile smooth muscle in association with nano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a3d852e4a892c999383ff400cfcb3b
https://research.rug.nl/en/publications/40b472ee-5d96-42ff-a9f4-eb0486b6fec4
https://research.rug.nl/en/publications/40b472ee-5d96-42ff-a9f4-eb0486b6fec4
Publikováno v:
DNA and Cell Biology
DNA and Cell Biology, Mary Ann Liebert, 2004, 23 (12), pp.842-848. ⟨10.1089/dna.2004.23.842⟩
DNA and Cell Biology, Mary Ann Liebert, 2004, 23 (12), pp.842-848. ⟨10.1089/dna.2004.23.842⟩
International audience; Breast cancer remains one of the most frequently diagnosed cancers today. In developed countries, one in eight women is expected to present with breast cancer within her lifetime and an estimated 1,000,000 cases are detected e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad77642a3b5cc9fa56c1816bca29ab9
https://doi.org/10.1089/dna.2004.23.842
https://doi.org/10.1089/dna.2004.23.842