Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mark Lucanic"'
Autor:
Daniel S Evans, Monique N O'Leary, Ryan Murphy, Minna Schmidt, Kristin Koenig, Michael Presley, Brittany Garrett, Ha‐Neui Kim, Li Han, Emmeline C Academia, Matt J Laye, Daniel Edgar, Christopher A Zambataro, Tracey Barhydt, Colleen M Dewey, Jarrott Mayfield, Joy Wilson, Silvestre Alavez, Mark Lucanic, Brian K Kennedy, Maria Almeida, Julie K Andersen, Pankaj Kapahi, Gordon J Lithgow, Simon Melov
Publikováno v:
JBMR Plus, Vol 5, Iss 3, Pp n/a-n/a (2021)
ABSTRACT Aging is characterized by systemic declines in tissue and organ functions. Interventions that slow these declines represent promising therapeutics to protect against age‐related disease and improve the quality of life. In this study, sever
Externí odkaz:
https://doaj.org/article/1488f0e2d6454063828ddeb29690b6a6
Autor:
Mark Lucanic, W. Todd Plummer, Esteban Chen, Jailynn Harke, Anna C. Foulger, Brian Onken, Anna L. Coleman-Hulbert, Kathleen J. Dumas, Suzhen Guo, Erik Johnson, Dipa Bhaumik, Jian Xue, Anna B. Crist, Michael P. Presley, Girish Harinath, Christine A. Sedore, Manish Chamoli, Shaunak Kamat, Michelle K. Chen, Suzanne Angeli, Christina Chang, John H. Willis, Daniel Edgar, Mary Anne Royal, Elizabeth A. Chao, Shobhna Patel, Theo Garrett, Carolina Ibanez-Ventoso, June Hope, Jason L Kish, Max Guo, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face
Externí odkaz:
https://doaj.org/article/2cab827465544f808fc531ab3590aa8a
Autor:
Karla A. Mark, Kathleen J. Dumas, Dipa Bhaumik, Birgit Schilling, Sonnet Davis, Tal Ronnen Oron, Dylan J. Sorensen, Mark Lucanic, Rachel B. Brem, Simon Melov, Arvind Ramanathan, Bradford W. Gibson, Gordon J. Lithgow
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1227-1237 (2016)
Summary: Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis. Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an increased risk of age-related chronic diseases, includi
Externí odkaz:
https://doaj.org/article/3f8a22d43d664bb88d686bd3cb8a33a3
Autor:
Pedro Reis Rodrigues, Tiffany K. Kaul, Jo-Hao Ho, Mark Lucanic, Kristopher Burkewitz, William B. Mair, Jason M. Held, Laura M. Bohn, Matthew S. Gill
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 6, Pp 1695-1705 (2016)
Under adverse environmental conditions the nematode Caenorhabditis elegans can enter an alternate developmental stage called the dauer larva. To identify lipophilic signaling molecules that influence this process, we screened a library of bioactive l
Externí odkaz:
https://doaj.org/article/bcf733c1a23e4a328fb0ad6cb05baf2a
Autor:
Mark Lucanic, Hwai-Jong Cheng
Publikováno v:
PLoS Genetics, Vol 4, Iss 11, p e1000269 (2008)
P21 activated kinase (PAK), PAK interacting exchange factor (PIX), and G protein coupled receptor kinase interactor (GIT) compose a highly conserved signaling module controlling cell migrations, immune system signaling, and the formation of the mamma
Externí odkaz:
https://doaj.org/article/583502c1d3f145a081ff6267a6f90816
Autor:
Cyrene Arputhasamy, Anna C. Foulger, Mark Lucanic, Anand Rane, Minna Schmidt, Theo Garrett, Michael Broussalian, Elena Battistoni, Rachel B. Brem, Gordon J. Lithgow, Manish Chamoli, Julie K. Andersen
Publikováno v:
GeroScience
Lysosomes are crucial for degradation and recycling of damaged proteins and cellular components. Therapeutic strategies enhancing lysosomal function are a promising approach for aging and age-related neurodegenerative diseases. Here, we show that an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d695f60b6eeea96ebb11d48a0c5d1829
https://doi.org/10.1007/s11357-022-00647-8
https://doi.org/10.1007/s11357-022-00647-8
Autor:
Anna C. Foulger, Jian Xue, D. Inman, Manish Chamoli, Michelle K. Chen, M. O. Schmidt, Gordon J. Lithgow, R. P. Quinn, Patrick C. Phillips, Suzhen Guo, W. T. Plummer, Mark Lucanic, S. A. Banse, Brian Onken, Phu Huynh, Ron Falkowski, Erik Johnson, Emily Y. Chen, David Hall, Monica Driscoll, Anna L. Coleman-Hulbert, Max Guo, Mackenzie L Morshead, Christine A Sedore, Daniel Edgar, Dipa Bhaumik, Girish Harinath, E. G. Jackson, Theo Garrett
The Caenorhabditis Intervention Testing Program (CITP) is an NIH-funded research consortium of investigators who conduct analyses at three independent sites to identify chemical interventions that reproducibly promote health and lifespan in a robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84c65f00c3a041d6c5a1cf05e8ad25d8
https://doi.org/10.1101/2021.11.09.464847
https://doi.org/10.1101/2021.11.09.464847
Autor:
Gordon J. Lithgow, Michael Broussalian, Anand Rane, Julie K. Andersen, Cyrene Arputhasamy, Theo Garett, Manish Chamoli, Rachel B. Brem, Anna C. Foulger, Elena Battistoni, Minna Schmidt, Mark Lucanic
Lysosomes are crucial for degradation and recycling of damaged proteins and cellular components. Therapeutic strategies enhancing lysosomal function are a promising approach for aging and age-related neurodegenerative diseases. Here, we show that an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77ffafd319382ffd35b193048f2cfb17
https://doi.org/10.1101/2021.10.21.465344
https://doi.org/10.1101/2021.10.21.465344
Autor:
Mark Lucanic, Pei-Hsin Huang, Hsiu Ming Shih, Chun Ta Ho, Wei-Wen Liu, Hwai-Jong Cheng, Shih-Yu Chen
Publikováno v:
Proc Natl Acad Sci U S A
During neural development, growing axons express specific surface receptors in response to various environmental guidance cues. These axon guidance receptors are regulated through intracellular trafficking and degradation to enable navigating axons t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68f88ffd5459db3dc17ba224b08302e
https://doi.org/10.1073/pnas.2100429118
https://doi.org/10.1073/pnas.2100429118
Autor:
Christopher D. Wiley, Brian Kaplowitz, Daniel Edgar, Chen-Yu Liao, Chisaka Kuehnemann, Yueh-Mei Hsu, Azar Asadi Shahmirzadi, Herbert G. Kasler, Dipa Bhaumik, Brian K. Kennedy, Rebeccah Riley, Arash Asadi Shahmirzadi, Mark Lucanic, Gordon J. Lithgow, Dong Eun Kim, Garbo Gan
Publikováno v:
Cell Metab
The decline in early life mortality since the 1950s has resulted in dramatic demographic shift towards aged population. Aging manifests as a decline in health, multiple organ dysfunction and increased vulnerability to diseases, which degrades quality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609f6f201b35630c28904db5e3bdb3cb
https://pubmed.ncbi.nlm.nih.gov/32877686
https://pubmed.ncbi.nlm.nih.gov/32877686