Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mark Lipsett"'
Morphological and Functional Studies on Submucosal Islet Transplants in Normal and Diabetic Hamsters
Publikováno v:
Cell Transplantation, Vol 11 (2002)
The long-term outcome of human islet allotransplantation is poor, and it remains to be seen if the Edmonton Protocol will make a positive impact upon the extension of posttransplant islet function. Hence, establishing an implantation site capable of
Externí odkaz:
https://doaj.org/article/055b90246e1d4ddaaa7d28b13d28c8cf
Autor:
C. Bruce Verchere, Mark Lipsett, Louise A. Scrocchi, Paul E. Fraser, Lawrence Rosenberg, Ziliang Ao, Marika A. Younker, Kathryn J. Potter, Garth L. Warnock
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1790:566-574
Background Amyloid fibrils created by misfolding and aggregation of proteins are a major pathological feature in a variety of degenerative diseases. Therapeutic approaches including amyloid vaccines and anti-aggregation compounds in models of amyloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ca67b83c01e2d836075bc3cb72de53
https://doi.org/10.1016/j.bbagen.2009.02.013
https://doi.org/10.1016/j.bbagen.2009.02.013
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1769:579-585
The regenerating (Reg) genes are associated with tissue repair and have been directly implicated in pancreatic beta-cell regeneration. A hamster Reg3, Islet neogenesis associated protein (INGAP), has been shown to possess anti-diabetic properties in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed38d8c1c972c559d8ee73197fcd8d6
https://doi.org/10.1016/j.bbaexp.2007.06.002
https://doi.org/10.1016/j.bbaexp.2007.06.002
Autor:
Aaron I. Vinik, David A. Taylor-Fishwick, Gary L. Pittenger, Marc Prentki, Mark Lipsett, Ji-Won Yoon, Lawrence Rosenberg, Rennian Wang, Hee-Sook Jun
Publikováno v:
Annals of Surgery. 240:875-884
The objective of this study was to demonstrate that islet neogenesis-associated protein (INGAP) peptide, a pentadecapeptide containing the biologically active portion of native INGAP, increases functional beta-cell mass in normal animals and can be u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43da82ee92ed869a75916c868a5b723b
https://doi.org/10.1097/01.sla.0000143270.99191.10
https://doi.org/10.1097/01.sla.0000143270.99191.10
Autor:
Steven Paraskevas, Hazrati A, Agapitos D, Dusica Maysinger, Mark Lipsett, Jamal Am, Lawrence Rosenberg
Publikováno v:
Cell Death & Differentiation. 10:987-996
Phenotypic change of adult pancreatic islets has been implicated in the development of certain pancreatic cancers and in islet transplant failure. The aim of this study was to characterize intracellular events that mediate changes in adult islet phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735aeb71c3e446c9e8832063b8c407d9
https://doi.org/10.1038/sj.cdd.4401266
https://doi.org/10.1038/sj.cdd.4401266
Autor:
Mark Lipsett, Lawrence Rosenberg
Publikováno v:
Expert Opinion on Biological Therapy. 3:319-337
The incidence of adenocarcinoma of the pancreas has risen steadily over the past four decades. Since pancreatic cancer is usually diagnosed at an advanced stage and because of the lack of effective therapies, the prognosis of such patients is extreme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96e4cbf9ccb8457c4931a0ea9e19a9e2
https://doi.org/10.1517/14712598.3.2.319
https://doi.org/10.1517/14712598.3.2.319
Publikováno v:
Pancreas. 34(4)
Objectives The plasticity of pancreatic tissue is demonstrated in many pancreatic diseases. It has previously been shown that pancreatic islet-to-duct transformation and acinoductal metaplasia have been associated with both pancreatic regeneration an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a1f2cbdbc533542be3c0b63b347f6f
https://pubmed.ncbi.nlm.nih.gov/17446845
https://pubmed.ncbi.nlm.nih.gov/17446845
Autor:
Jean Tchervenkov, Stephen C. Hanley, Steven Paraskevas, S. Liu, Mark Lipsett, Mauro Castellarin, Lawrence Rosenberg
Publikováno v:
Transplantation. 82(6)
BACKGROUND Recent successes in islet transplantation highlight the importance of islet isolation by experienced centers and minimization of cell injury as crucial to the achievement of insulin independence. Islet injury may manifest as cell death by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdd2fba4dc3a7e01f7c4d7698fc2053
https://pubmed.ncbi.nlm.nih.gov/17006329
https://pubmed.ncbi.nlm.nih.gov/17006329
Autor:
Mauro Castellarin, Dusica Maysinger, Stephen C. Hanley, Reid Aikin, Mark Lipsett, Steven Paraskevas, Lawrence Rosenberg
Publikováno v:
Diabetologia. 49(12)
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a critical role in promoting the survival of pancreatic beta cells. Akt becomes activated in isolated human islets following overnight culture despite significant levels of cell death. The ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38244cea44efbadae5c7cf7b48911d9e
https://pubmed.ncbi.nlm.nih.gov/17053882
https://pubmed.ncbi.nlm.nih.gov/17053882
Publikováno v:
Diabetologia. 49(12)
Diabetes results from an insufficient insulin-secreting beta cell mass. Restoration of beta cell mass through pharmaceutically induced endogenous beta cell mass expansion may revolutionise diabetes therapy. However, it remains to be determined whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40089fc47efaea2d9e558c575099a1ab
https://pubmed.ncbi.nlm.nih.gov/17096119
https://pubmed.ncbi.nlm.nih.gov/17096119