A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Autor: Christopher Thomas, Owen R. Davies, Rebecca J. Harris, Jonathan M.G. Higgins, Scott T. Kerridge, Benjamin Wetherall, Mark Levasseur, Suzanne Madgwick

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Thomas, C, Wetherall, B, Levasseur, M D, Harris, R J, Kerridge, S T, Higgins, J M G, Davies, O R & Madgwick, S 2021, ' A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes ', Nature Communications, vol. 12, 4322 . https://doi.org/10.1038/s41467-021-24554-2

Successful cell division relies on the timely removal of key cell cycle proteins such as securin. Securin inhibits separase, which cleaves the cohesin rings holding chromosomes together. Securin must be depleted before anaphase to ensure chromosome s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc04b6ddeb0503682f180e0460bd5329
https://doaj.org/article/bdaa966adbcf4843a925b336289c52d4

Synchronous chromosome segregation in mouse oocytes is ensured by biphasic securin destruction and cyclin B1-Cdk1

Autor: Rebecca J. Harris, Suzanne Madgwick, Owen R. Davies, Mark Levasseur, Christopher Thomas

Successful cell division relies on the faithful segregation of chromosomes. If chromosomes segregate prematurely the cell is at risk of aneuploidy. Alternatively, if cell division is attempted in the absence of complete chromosome segregation, non-se

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Prometaphase APCcdh1 activity prevents non-disjunction in mammalian oocytes

Autor: Suzanne Madgwick, A. Reis, Ibtissem Nabti, Mark Levasseur, Heng Yu Chang, Keith T. Jones

Publikováno v: Nature Cell Biology. 9:1192-1198

The first female meiotic division (meiosis I, MI) is uniquely prone to chromosome segregation errors through non-disjunction, resulting in trisomies and early pregnancy loss. Here, we show a fundamental difference in the control of mammalian meiosis

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https://doi.org/10.1038/ncb1640

RNA interference in meiosis I human oocytes: towards an understanding of human aneuploidy

Autor: Alison Murdoch, Mary Herbert, Alex McDougall, Hayden Homer, Mark Levasseur

Publikováno v: Molecular Human Reproduction
Molecular Human Reproduction, Oxford University Press (OUP), 2005, 11 (6), pp.397-404. ⟨10.1093/molehr/gah184⟩

International audience; Although female meiosis I errors account for the majority of human aneuploidy, their molecular basis is largely unknown. By elucidating gene function, gene knockdown using RNA interference (RNAi) could shed light on this enigm

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https://doi.org/10.1093/molehr/gah184

Maintenance of sister chromatid attachment in mouse eggs through maturation-promoting factor activity

Autor: Victoria L. Nixon, Mary Herbert, Heng Yu Chang, Mark Levasseur, Suzanne Madgwick, Keith T. Jones

Publikováno v: Developmental Biology. 275(1):68-81

Mammalian eggs naturally arrest at metaphase of the second meiotic division, until sperm triggers a series of Ca(2+) spikes that result in activation of the anaphase-promoting complex/cyclosome (APC/C). APC/C activation at metaphase targets destructi

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