Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mark Lefever"'
Autor:
Larry E. Morrison, Lauren Behman, Torsten Leibold, Daniel Bauer, Esteban Roberts, Mark Lefever, Uwe B Horchner
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Brightfield microscopy is the preferred method of pathologists for diagnosing solid tumors, utilizing common staining techniques such as hematoxylin and eosin staining and immunohistochemistry (IHC). However, as our understanding of the complex tumor
Autor:
Mark Lefever, Antony Hubbard, Adriana Racolta, Zhenqiang Lu, Frank Ventura, Lei Tang, Wenjun Zhang, William Day, Karl Garsha, Tobin Jones, Larry E. Morrison, Liping Zhang, Lidija Pestic-Dragovich, John K. Hurley, Srabani Bhaumik, Nick Cummins
Publikováno v:
Laboratory Investigation. 97:873-885
The ability to simultaneously visualize the presence, abundance, location and functional state of many targets in cells and tissues has been described as a true next-generation approach in immunohistochemistry (IHC). A typical requirement for multipl
Autor:
Lauren Behman, Mark Lefever, Jerry Kosmeder, Larry E. Morrison, Robert L. Ochs, Esteban Roberts, Julia Ashworth-Sharpe, James Grille, Donald Johnson, Anne Pedata, Eric May, William Day
Publikováno v:
Laboratory Investigation. 97:104-113
Multiplexed analysis of multiple biomarkers in a tissue sample requires use of reporter dyes with specific spectral properties that enable discrimination of signals. Conventional chromogens with broad absorbance spectra, widely used in immunohistoche
Autor:
Mark Lefever, Lauren Behman, Julia Ashworth-Sharpe, Torsten Leibold, Larry E. Morrison, Esteban Roberts, Daniel Bauer
Publikováno v:
Cancer Research. 80:4250-4250
Introduction. Brightfield microscopy is the current gold standard for tissue-based cancer diagnoses and has long been the choice of pathologists. Accordingly, the clinical use of brightfield-based immunohistochemistry (IHC) far exceeds immunofluoresc
Autor:
Lajos Szabo, Mark Lefever, Joanna Hogan, Bobbi Anglin, Lauren Cooney, Michael J. Ferracane, Robin Polt
Publikováno v:
Carbohydrate Research. 351:121-125
A simplified method for the preparation of Fmoc-serine and Fmoc-threonine glycosides for use in O-linked glycopeptide synthesis is described. Lewis acids promote glycoside formation, but also promote undesired reactions of the glycoside products. Use
Publikováno v:
Bioconjugate Chemistry. 21:1773-1778
A novel method of linking haptens to deoxycytidine 5'-triphosphate via microwave-mediated bisulfate-catalyzed transamination with hydrazine has been developed. This method enables the tethering of small molecule haptens to dCTP via a discrete polyeth
Autor:
Jian Zhang, Tsu-Shuen Tsao, Hongjun Zhang, Brian D. Kelly, William Day, Nathan W. Polaske, Donald Johnson, Robert L. Ochs, Mark Lefever, Jerry Kosmeder, Michael Farrell, Joerg Bredno, Julia Ashworth-Sharpe, Esteban Roberts, Larry E. Morrison
Publikováno v:
Cancer Research. 78:1600-1600
Introduction Immunohistochemistry (IHC) is a valuable means to examine the distribution of protein expression at the subcellular level throughout human tissues while retaining morphology of the cells and tissue. Given the large and growing number of
Autor:
Edward J. Bilsky, John J. Lowery, Denise Giuvelis, Jean M. Bidlack, Brian I. Knapp, Dhanasekaran Muthu, Yingxue Li, Bobbi Anglin, Mark Lefever, Robin Polt
Publikováno v:
Journal of medicinal chemistry. 58(15)
Glycopeptides related to β-endorphin penetrate the blood-brain barrier (BBB) of mice to produce antinociception. Two series of glycopeptides were assessed for opioid receptor binding affinity. Attempts to alter the mu-selectivity of [D-Ala(2),N-MePh
Over the past two decades, potent and selective analgesics have been developed from endogenous opioid peptides. Glycosylation provides an important means of modulating interaction with biological membranes, which greatly affects the pharmacodynamics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109e1c733c0dcc4f22f06de17d69a1aa
https://europepmc.org/articles/PMC3306179/
https://europepmc.org/articles/PMC3306179/
Autor:
Natasja Brooijmans, Ker Yu, Arie Zask, Jeroen C. Verheijen, Judy Lucas, David J. Richard, Semiramis Ayral-Kaloustian, Mark Lefever, Kevin J. Curran, Weiguo Zhang, Lourdes Toral-Barza, Pawel Nowak, Tarek S. Mansour, Irwin Hollander, David Malwitz, Joshua Kaplan
Publikováno v:
Journal of medicinal chemistry. 52(24)
Design and synthesis of a series of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as potent and selective inhibitors of the mammalian target of rapamycin (mTOR) are described. Optimization of the 6-aryl substituent led to the discovery of inhibit