Zobrazeno 1 - 10
of 2 136
pro vyhledávání: '"Mark Lautens"'
Autor:
Jessica Knox, Andrew R. Burns, Brittany Cooke, Savina R. Cammalleri, Megan Kitner, Justin Ching, Jack M. P. Castelli, Emily Puumala, Jamie Snider, Emily Koury, J. B. Collins, Salma Geissah, James J. Dowling, Erik C. Andersen, Igor Stagljar, Leah E. Cowen, Mark Lautens, Inga Zasada, Peter J. Roy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Left unchecked, plant-parasitic nematodes have the potential to devastate crops globally. Highly effective but non-selective nematicides are justifiably being phased-out, leaving farmers with limited options for managing nematode infestation
Externí odkaz:
https://doaj.org/article/609af50dc9664af39474ef0017566555
Autor:
Sean Harrington, Jacob Pyche, Andrew R. Burns, Tina Spalholz, Kaetlyn T. Ryan, Rachel J. Baker, Justin Ching, Lucien Rufener, Mark Lautens, Daniel Kulke, Alexandre Vernudachi, Mostafa Zamanian, Winnie Deuther-Conrad, Peter Brust, Peter J. Roy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Harrington et al report their discovery of Nemacol, which is a small molecule inhibitor of the vesicular acetylcholine transporter (VAChT). VAChT loads synaptic vesicles with acetylcholine and is a key point of vulnerability in animals. Harrington et
Externí odkaz:
https://doaj.org/article/ba9e1ce1202e44218ebb2d413e5ef720
Autor:
Sean Harrington, Jessica J. Knox, Andrew R. Burns, Ken-Loon Choo, Aaron Au, Megan Kitner, Cecile Haeberli, Jacob Pyche, Cassandra D’Amata, Yong-Hyun Kim, Jonathan R. Volpatti, Maximillano Guiliani, Jamie Snider, Victoria Wong, Bruna M. Palmeira, Elizabeth M. Redman, Aditya S. Vaidya, John S. Gilleard, Igor Stagljar, Sean R. Cutler, Daniel Kulke, James J. Dowling, Christopher M. Yip, Jennifer Keiser, Inga Zasada, Mark Lautens, Peter J. Roy
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
A C. elegans-based screening approach identifies nementin as a nematode-selective nematicide that can be used synergistically with acetylcholinesterase inhibitors
Externí odkaz:
https://doaj.org/article/b2ae40e60cd44727b137593ac69b190f
Autor:
Eric N. Donders, Kai V. Slaughter, Christian Dank, Ahil N. Ganesh, Brian K. Shoichet, Mark Lautens, Molly S. Shoichet
Publikováno v:
Advanced Science, Vol 10, Iss 13, Pp n/a-n/a (2023)
Abstract Colloidal drug aggregates enable the design of drug‐rich nanoparticles; however, the efficacy of stabilized colloidal drug aggregates is limited by entrapment in the endo‐lysosomal pathway. Although ionizable drugs are used to elicit lys
Externí odkaz:
https://doaj.org/article/6381e627e47b4947a800447fbe4cab1f
Autor:
Andrew R. Burns, Rachel J. Baker, Megan Kitner, Jessica Knox, Brittany Cooke, Jonathan R. Volpatti, Aditya S. Vaidya, Emily Puumala, Bruna M. Palmeira, Elizabeth M. Redman, Jamie Snider, Sagar Marwah, Sai W. Chung, Margaret H. MacDonald, Jens Tiefenbach, Chun Hu, Qi Xiao, Constance A. M. Finney, Henry M. Krause, Sonya A. MacParland, Igor Stagljar, John S. Gilleard, Leah E. Cowen, Susan L. F. Meyer, Sean R. Cutler, James J. Dowling, Mark Lautens, Inga Zasada, Peter J. Roy
Publikováno v:
Nature. 618:102-109
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d256724eac25ff571f398783e9bf2a3e
https://doi.org/10.1038/s41586-023-06105-5
https://doi.org/10.1038/s41586-023-06105-5
Publikováno v:
ACS Catalysis. 13:6562-6567
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05eb3745d2b28afbbb5bb7a5716de672
https://doi.org/10.1021/acscatal.3c01055
https://doi.org/10.1021/acscatal.3c01055
Publikováno v:
Chemical Science. 14:5650-5655
A palladium-catalyzed spirocyclization reaction is reported and proposed to arise via diastereoselective insertion of an oxabicycle into a palladacycle. The cycloadduct undergoes a post-catalytic retro-Diels–Alder step to furnish a previously inacc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::551dfa09119f9f3670f9e321b0731448
https://doi.org/10.1039/d3sc01072d
https://doi.org/10.1039/d3sc01072d
Publikováno v:
ACS Catalysis. 12:15130-15134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ddcbfea0a274d44ecc372212af1a20b
https://doi.org/10.1021/acscatal.2c04818
https://doi.org/10.1021/acscatal.2c04818
Publikováno v:
Journal of the American Chemical Society. 144:20554-20560
A Pd(0)/blue light catalyzed carboiodination reaction is reported. A simple, air-stable catalytic system, utilizing [Pd(allyl)Cl]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e8bd50c5dfb2fcc93ea56a73b8cf0f
https://doi.org/10.1021/jacs.2c09716
https://doi.org/10.1021/jacs.2c09716
Publikováno v:
ACS Catalysis. 12:12744-12749
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::156bcf5f44ade80c606b3e439984bde9
https://doi.org/10.1021/acscatal.2c04128
https://doi.org/10.1021/acscatal.2c04128