Výsledky vyhledávání - "Mark Lackner"

Supplementary Figures 1-3, Tables 1-3 from Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAFV600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Suppression

Autor: Marcia Belvin, Lori S. Friedman, Lesley Murray, Edna Choo, Howard Stern, Mark Lackner, Somasekar Seshagiri, Zora Modrusan, Carol O'Brien, Jocelyn Chan, Leanne Berry, Leo Wong, Janet Tien, Sylvia Herter, Klaus P. Hoeflich

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000bf1acfe087dacefbc2545a632b2dc
https://doi.org/10.1158/0008-5472.22379676

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Data from Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAFV600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Suppression

Oncogenic activation of the BRAF serine/threonine kinase has been associated with initiation and maintenance of melanoma tumors. As such, development of pharmacologic agents to target RAF proteins or their effector kinases is an area of intense inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64188e77c1429c035f07f170fb3888d9
https://doi.org/10.1158/0008-5472.c.6499326.v1

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Supplementary Figure Legends 1-3 from Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAFV600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Suppression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d756bb12ee50fb93bfa2770676447a6
https://doi.org/10.1158/0008-5472.22379679.v1

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Abstract 2153: Cyclin E1 protein overexpression sensitizes ovarian cancer cells to ZN-c3, a novel, selective and oral bioavailable inhibitor of Wee1

Autor: Jianhui Ma, Wen Liu, Heekyung Chung, Hooman Izadi, Petrus DeJong, Olivier Harismendy, Jia li, Fernando Doñate, Ahmed Samatar, Mark Lackner, Laure Escoubet, Kevin Bunker, Daehwan Kim, Nathan Jameson, Tugba Yildiran Ozmen, Kangjin Jeong, Dong Zhang, Wen-An Pan, Gordon Mills

Publikováno v: Cancer Research. 83:2153-2153

CCNE1 gene amplification is associated with overexpression of Cyclin E1 protein and is an important oncogenic driver. CCNE1 amplification is common in high grade serous ovarian carcinomas (HGSOC) and is associated with platinum resistance and poor pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0bc9cc4eb7f29f6889684e7620b9703
https://doi.org/10.1158/1538-7445.am2023-2153

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Abstract 6093: IDE161, a potential first-in-class clinical candidate PARG inhibitor, selectively targets homologous-recombination-deficient and PARP inhibitor resistant breast and ovarian tumors

Autor: Monah Abed, Diana Muñoz, Vidya Seshadri, Steve Federowicz, Arjun A. Rao, Deepthi Bhupathi, Marya Liimatta, Rita Ousterhout, Firoz Jaipuri, Claire Neilan, Mark Lackner, Mike White, Zineb Mounir

Publikováno v: Cancer Research. 83:6093-6093

Poly (ADP-ribose) polymerase inhibitors (PARPi) were the first clinically approved drugs designed to exploit synthetic lethality. Despite initial responses, patients harboring homologous recombination (HR) alterations that receive PARPi develop treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::360035d9122cbe3c5020c7fd57598c2f
https://doi.org/10.1158/1538-7445.am2023-6093

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