Zobrazeno 1 - 2
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pro vyhledávání: '"Mark L.G. Borst"'
Publikováno v:
Organic & Biomolecular Chemistry, 19(46). ROYAL SOC CHEMISTRY
The first multi-gram synthesis of enantiopure dihydroxyethyl acetamidofuran (Di-HAF) is reported. Under optimized conditions, GlcNAc dehydrates in pyridine in the presence of phenylboronic acid and triflic acid to afford Di-HAF in 73% yield and 99.3%
Autor:
Mark L.G. Borst, Rob Libbers, Zhou M. Lion, Rijko Ebens, Kees Pouwer, Rutger F. Bus, Khaled A. Attia, Alessandro Cecchi, Susan Snijder, Cécile M.J. Ouairy, Jessica M. C. A. Kerckhoffs, Marieke Hazewinkel, Rob van der Hulst, Bart W. Settels, Sander C. Fokkema, Piet-Jan Sinnema, Vincent L. de Boer, Peter J. van den Boogaard, Joop Knol, Ellen de Wever, Jesse M. de Gooijer, Karen Harkema
Publikováno v:
ACS combinatorial science. 20(6)
The design and synthesis of three novel polycyclic scaffolds containing sulfoximines are presented in this work, which exemplify that sulfoximines represent a real opportunity for the discovery of new drug candidates. Additionally, the structures pre