Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mark L. Wolfe"'
Autor:
Scott A. Yerby, Chelsea S. Bahney, Mark L. Wolfe, Shane A. Woods, Regina F. MacBarb, Derek P. Lindsey
Publikováno v:
International journal of spine surgery. 11
Background An aging society and concomitant rise in the incidence of impaired bone health have led to the need for advanced osteoconductive spinal implant surfaces that promote greater biological fixation (e.g. for interbody fusion cages, sacroiliac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc60824910efa339e5d785c5dd3d306
https://pubmed.ncbi.nlm.nih.gov/28765799
https://pubmed.ncbi.nlm.nih.gov/28765799
Autor:
Mark L. Wolfe, Jacob Bode, H. David Fischer, Merrill S. Babcock, W. Rodney Mathews, Gurnam S. Gill, Robert L. Garlick, Eric T. Baldwin, Shenping Liu, Jeanne S. Chang, Bruce N. Rogers, Brandon J. Margolis, Eric T. Lund, Vince Groppi
Publikováno v:
Protein Expression and Purification. 79:102-110
Nicotinic acetylcholine receptors (nAChRs) form ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are members of a large family of pentameric ion channels that are of active medical interest. An expression s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5ad9a679c3ecb882f12cae4e556bb3
https://doi.org/10.1016/j.pep.2011.05.019
https://doi.org/10.1016/j.pep.2011.05.019
Autor:
Raymond S. Hurst, Bruce N. Rogers, Mihály Hajós, Rodney R. Walters, Donn G. Wishka, Brian A. Staton, David W. Piotrowski, Brad A. Acker, Kai S. Li, Michael Krause, Vincent E. Groppi, William E. Hoffmann, Daniel P. Walker, Barbara A. Olson, Laura Fitzgerald, E. Jon Jacobsen, Thomas J. Raub, Mark L. Wolfe, Bruce A. Thornburgh, Paula M. Tinholt, Steven Charles Reitz, Jason K. Myers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3611-3615
A novel α7 nAChR agonist, N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (3a, PHA-709829), has been identified for the potential treatment of cognitive deficits in schizophrenia. The compound shows potent and selective α7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4401b56d4c1dc535fb66dd987f2e99f3
https://doi.org/10.1016/j.bmcl.2008.04.070
https://doi.org/10.1016/j.bmcl.2008.04.070
Autor:
Daniel P. Walker, Barbara A. Olson, Fusen Han, E. Jon Jacobsen, Raymond S. Hurst, Shaojuan Jia, Lester A. Dolak, Brandon J. Margolis, Nicole R. Higdon, Tatiana N. Vetman, David W. Piotrowski, Brian A. Staton, Matthew R. Hester, Luz A. Cortes-Burgos, Erik H. F. Wong, Theron M. Wall, Steven Charles Reitz, Vincent E. Groppi, Bruce N. Rogers, Kai S. Li, Brad A. Acker, Bruce A. Thornburgh, Paula M. Tinholt, Jason K. Myers, Mihály Hajós, Thomas J. Raub, Mark L. Wolfe, Karen M. Yates, William E. Hoffmann, Laura Fitzgerald, Donn G. Wishka, Eric P. Seest, Rodney R. Walters
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:8219-8248
A novel set of azabicyclic aryl amides have been identified as potent and selective agonists of the alpha7 nAChR. A two-pronged approach was taken to improve the potential hERG liability of previously disclosed alpha7 nAChR agonist, PNU-282,987, whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058d11e4149544128cfd448da56d7569
https://doi.org/10.1016/j.bmc.2006.09.019
https://doi.org/10.1016/j.bmc.2006.09.019
Autor:
Arneric Sp, Karen K. Cook, Thomas J. Raub, Bruce N. Rogers, Mark L. Wolfe, Eric Jon Jacobsen, Vincent E. Groppi, Carey G, Brian A. Staton, Daniel P. Walker, Raymond S. Hurst, Luz A. Cortes-Burgos, Rodney R. Walters, Donn G. Wishka, Theron M. Wall, Jia S, Hanchar Aj, Karen M. Yates, Steven B. Sands, Bruce A. Thornburgh, Gold Lh, Soglia, Jason K. Myers, Franklin S, Steven Charles Reitz, Sabrina X. Zhao, Amit S. Kalgutkar, Nicole R. Higdon, Olson Kl, Erik H. F. Wong, Mihály Hajós, William E. Hoffmann
Publikováno v:
Journal of Medicinal Chemistry. 49:4425-4436
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a novel agonist of the alpha7 neuronal nicotinic acetylcholine receptor (alpha7 nAChR), has been identified as a potential treatment of cognitive deficits in sch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fbbbb19eb89de61edd6e606a68da00
https://doi.org/10.1021/jm0602413
https://doi.org/10.1021/jm0602413
Autor:
Raymond S. Hurst, Vincent E. Groppi, Bruce N. Rogers, Alice L. Bodnar, Theron M. Wall, Luz A. Cortes-Burgos, Jason K. Myers, Dac M. Dinh, Nicole R. Higdon, Mark L. Wolfe, Erik H. F. Wong, Karen K. Cook, Mihály Hajós, William E. Hoffmann
Publikováno v:
Journal of Medicinal Chemistry. 48:905-908
A library of benzamides was tested for alpha7 nicotinic acetylcholine receptor (nAChR) agonist activity using a chimeric receptor in a functional, cell-based, high-throughput assay. From this library, quinuclidine benzamides were found to have alpha7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c869cd816f6b43ca88a5152d5473990d
https://doi.org/10.1021/jm049363q
https://doi.org/10.1021/jm049363q
Autor:
Bharat V. Kamdar, William Watt, Mark L. Wolfe, Vincent E. Groppi, Loretta A. Cipkus Dubray, Michael P. Smith, Robert C. Gadwood, Stephen A. Mizsak
Publikováno v:
Journal of Medicinal Chemistry. 36:1480-1487
A series of novel spirocyclic benzopyran imidazolones were synthesized as rigid analogues of cromakalim. These compounds cause a dose-dependent membrane hyperpolarization of A10 rat aorta cells. This hyperpolarization was blocked by pretreatment with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57f66c957fa23d8308e33d322ac38c8
https://doi.org/10.1021/jm00062a022
https://doi.org/10.1021/jm00062a022
Autor:
Robert L Garlick, Veronica T Mutchler, Ericka L Benson, Mark L Wolfe, Gil H. Choi, Jeanne C. Hagadorn, Paul K. Tomich
Publikováno v:
Analytical biochemistry. 324(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ac894d29605340e512ade79b6a8b22
https://pubmed.ncbi.nlm.nih.gov/14690695
https://pubmed.ncbi.nlm.nih.gov/14690695
Autor:
M. Clark, Jill A. Dalton, Nicole R. Higdon, Mark L. Wolfe, Theodore J. Baird, David V. Gauvin, Theron Wall
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 58:168-169
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf5aac71ff8c2d794b56fd45c7372e5
https://doi.org/10.1016/j.vascn.2008.05.093
https://doi.org/10.1016/j.vascn.2008.05.093
Publikováno v:
Chemistry and physics of lipids. 69(2)
The steady-state and dynamic fluorescence properties of the membrane potential-sensitive bis-oxonol dye Dibac4(3) were characterized in vitro using model ligand systems and in vivo in A10 smooth muscle cells by fluorescence microscopy in conjunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d43a581df9dc6bf07bde7c97734c2b9
https://pubmed.ncbi.nlm.nih.gov/8181103
https://pubmed.ncbi.nlm.nih.gov/8181103